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Osteo Arthritis Knee

3
Pipeline Programs
11
Companies
10
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Purdue Pharma
Purdue PharmaCT - Stamford
1 program
1
V120083Phase 21 trial
Active Trials
NCT03028870Completed291Est. Nov 2017
Shionogi
ShionogiJapan - Osaka
1 program
1
V120083Phase 2
Akan Biosciences
Akan BiosciencesMD - Gaithersburg
1 program
1
StroMelPhase 1/21 trial
Active Trials
NCT04750252Not Yet Recruiting20Est. Aug 2027
Zimmer Biomet
Zimmer BiometFL - Jacksonville
2 programs
Persona IQN/A1 trial
Total Knee ReplacementN/A1 trial
Active Trials
NCT06089291Enrolling By Invitation200Est. Dec 2027
NCT05966519Recruiting80Est. Jan 2029
Stryker
StrykerCA - San Jose
2 programs
TKR with mechanical alignment methodN/A
Total knee arthroplasyN/A1 trial
Active Trials
NCT04092153Completed100Est. Feb 2025
Medtronic
MedtronicNJ - Phillipsburg
1 program
Geniculate Artery EmbolizationN/A1 trial
Active Trials
NCT03362957Completed21Est. Apr 2020
Moximed
MoximedCA - Fremont
1 program
MISHA Knee SystemN/A1 trial
Active Trials
NCT06118892Recruiting120Est. Jul 2030
Medacta
MedactaSwitzerland - Castel San Pietro
1 program
MyKnee with single use Efficiency InstrumentN/A1 trial
Active Trials
NCT03427047Completed82Est. Jan 2022
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
TKR with mechanical alignment methodN/A1 trial
Active Trials
NCT03196011Active Not Recruiting126Est. Dec 2025
restor3d
restor3dNC - Durham
1 program
iTotal Posterior StabilizedN/A1 trial
Active Trials
NCT03289000Completed93Est. Dec 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Purdue PharmaV120083
Akan BiosciencesStroMel
Zimmer BiometPersona IQ
Zimmer BiometTotal Knee Replacement
MoximedMISHA Knee System
StrykerTotal knee arthroplasy
Nordic PharmaTKR with mechanical alignment method
MedactaMyKnee with single use Efficiency Instrument
MedtronicGeniculate Artery Embolization
restor3diTotal Posterior Stabilized

Clinical Trials (10)

Total enrollment: 1,133 patients across 10 trials

NCT03028870Purdue PharmaV120083

A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee

Start: Mar 2017Est. completion: Nov 2017291 patients
Phase 2Completed
NCT04750252Akan BiosciencesStroMel

Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee Joint

Start: Oct 2025Est. completion: Aug 202720 patients
Phase 1/2Not Yet Recruiting
NCT06089291Zimmer BiometPersona IQ

Persona IQ Cohort Study

Start: Feb 2024Est. completion: Dec 2027200 patients
N/AEnrolling By Invitation
NCT05966519Zimmer BiometTotal Knee Replacement

ROSA Knee Intraoperative Planning Flexibility Study

Start: Jan 2024Est. completion: Jan 202980 patients
N/ARecruiting
NCT06118892MoximedMISHA Knee System

MISHA Post-Market Clinical Study

Start: Nov 2023Est. completion: Jul 2030120 patients
N/ARecruiting
NCT04092153StrykerTotal knee arthroplasy

Mako Functionally Aligned Total Knee Arthroplasty vs Mako Mechanically Aligned Total Knee Arthroplasty

Start: Dec 2018Est. completion: Feb 2025100 patients
N/ACompleted
NCT03196011Nordic PharmaTKR with mechanical alignment method

Traditional Versus Alternative Alignment in TKR

Start: Oct 2018Est. completion: Dec 2025126 patients
N/AActive Not Recruiting
NCT03427047MedactaMyKnee with single use Efficiency Instrument

Comparing Surgical and Economical Parameters of Total Knee Replacement.

Start: Aug 2018Est. completion: Jan 202282 patients
N/ACompleted
NCT03362957MedtronicGeniculate Artery Embolization

Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)

Start: May 2018Est. completion: Apr 202021 patients
N/ACompleted
NCT03289000restor3diTotal Posterior Stabilized

A Retrospective Study to Evaluate the ConforMIS iTotal® Posterior Stabilized (PS) Knee Replacement System

Start: Apr 2017Est. completion: Dec 201793 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 1,133 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.