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Orthostatic Hypotension

4
Pipeline Programs
4
Companies
5
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Lundbeck
NORTHERAApproved
droxidopa
Lundbeck
oral2014
28M Part D

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Lundbeck
LundbeckDenmark - Copenhagen
1 program
1
Droxidopa 100 MG [Northera]Phase 41 trial
Active Trials
NCT04510922Completed9Est. Dec 2020
TSH Biopharm
TSH BiopharmTaiwan - Taipei
1 program
1
DroxidopaPhase 31 trial
Active Trials
NCT01612078Terminated25
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
Routine treatmentPhase 21 trial
Active Trials
NCT05647473Unknown66Est. May 2025
Boston Scientific
Boston ScientificCA - Valencia
2 programs
Wearable heart monitorN/A1 trial
Wearable holter monitorN/A1 trial
Active Trials
NCT03721393Completed50Est. May 2023
NCT07502599Not Yet Recruiting40Est. Jul 2028

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
LundbeckDroxidopa 100 MG [Northera]
TSH BiopharmDroxidopa
UNION therapeuticsRoutine treatment
Boston ScientificWearable holter monitor
Boston ScientificWearable heart monitor

Clinical Trials (5)

Total enrollment: 190 patients across 5 trials

NCT04510922LundbeckDroxidopa 100 MG [Northera]

Lundbeck TOMs Orthostatic Hypotension

Start: Feb 2019Est. completion: Dec 20209 patients
Phase 4Completed
NCT01612078TSH BiopharmDroxidopa

Phase 3 Study to Evaluate the Efficacy and Safety of Droxidopa on Orthostatic Hypotension Treatment in Hemodialysis Patients

Start: Jun 201225 patients
Phase 3Terminated
NCT05647473UNION therapeuticsRoutine treatment

Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension

Start: Feb 2024Est. completion: May 202566 patients
Phase 2Unknown
NCT07502599Boston ScientificWearable holter monitor

Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)

Start: May 2026Est. completion: Jul 202840 patients
N/ANot Yet Recruiting
NCT03721393Boston ScientificWearable heart monitor

Data Collection - Of Syncope Tilt Table Testing Study

Start: Oct 2019Est. completion: May 202350 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.