Opiate Addiction
3
Pipeline Programs
4
Companies
4
Clinical Trials
1
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
1
Early DiscoveryClinical DevelopmentMarket
On Market (1)
Approved therapies currently available
U
LOFEXIDINE HYDROCHLORIDEApproved
lofexidine
Unknown Companyoral2025
Competitive Landscape
4 companies ranked by most advanced pipeline stage
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
US WorldMedsLofexidine
Jazz PharmaceuticalsCBD 400 mg
OrexoAiCure monitoring and intervention
Merck & Co.Nexplanon
Clinical Trials (4)
Total enrollment: 509 patients across 4 trials
Lofexidine for Inpatient Opiate Detox
Start: Jun 2006Est. completion: Oct 2007264 patients
Phase 3Completed
Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans
Start: Sep 2015Est. completion: May 201745 patients
Phase 2Completed
Using Artificial Intelligence To Monitor Medication Adherence in Opioid Replacement Therapy
Start: Aug 2016Est. completion: Mar 2017
N/ACompleted
Immediate Postpartum Nexplanon Placement in Opioid Dependent Women
Start: May 2016Est. completion: Aug 2018200 patients
N/ACompleted
Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
1 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space