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Ocular Pain

3
Pipeline Programs
4
Companies
5
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Alcon
AlconFORT WORTH, TX
1 program
1
acoltremon ophthalmic solution 0.003%Phase 41 trial
Active Trials
NCT07849803Not Yet Recruiting28Est. Jun 2027
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
BL1332Phase 2
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
BL1332 ophthalmic solutionPhase 11 trial
Active Trials
NCT06978244Active Not Recruiting24Est. Nov 2026
Sylentis
SylentisSpain - Madrid
3 programs
SYL1001PHASE_11 trial
SYL1001PHASE_1_21 trial
SYL1001PHASE_21 trial
Active Trials
NCT01438281Completed30Est. Jun 2012
NCT01776658Completed60
NCT02455999Completed66

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Alconacoltremon ophthalmic solution 0.003%
SylentisSYL1001
SylentisSYL1001
Bausch HealthBL1332 ophthalmic solution
SylentisSYL1001

Clinical Trials (5)

Total enrollment: 208 patients across 5 trials

NCT07849803Alconacoltremon ophthalmic solution 0.003%

Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain

Start: Oct 2026Est. completion: Jun 202728 patients
Phase 4Not Yet Recruiting

Dose-finding Study to Assess the Safety and Effect of SYL1001 in Patients With Ocular Pain

Start: Jun 201566 patients
Phase 2Completed

Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain

Start: Nov 201260 patients
Phase 1/2Completed
NCT06978244Bausch HealthBL1332 ophthalmic solution

A Study to Assess Safety, Tolerability, and Pharmacokinetics of Ascending Concentrations of Topical Ocular BL1332 in Healthy Volunteers

Start: Jul 2025Est. completion: Nov 202624 patients
Phase 1Active Not Recruiting

Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy Volunteers

Start: Jul 2011Est. completion: Jun 201230 patients
Phase 1Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.