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Obstructive Sleep Apnea

22
Pipeline Programs
30
Companies
50
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
2
6
1
6
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
150%
Peptide
150%
+ 114 programs with unclassified modality

Competitive Landscape

30 companies ranked by most advanced pipeline stage

Inspire Medical Systems
10 programs
1
2
Inspire® Upper Airway StimulationPhase 41 trial
Inspire® Upper Airway StimulationPhase 41 trial
Inspire Upper Airway Stimulation SystemPhase 31 trial
Home Sleep TestingN/A1 trial
Inspire SystemN/A1 trial
+5 more programs
Active Trials
NCT04416542Completed64Est. Jun 2022
NCT06540716Recruiting44Est. Dec 2025
NCT06971796Recruiting1,000Est. Apr 2035
+7 more trials
Medtronic
MedtronicNJ - Phillipsburg
5 programs
1
Pillar Palatal ImplantsPhase 41 trial
Clinical Evaluation of an Apnea Index for Diagnosis and Screening of Obstructive Sleep Apnea (OSA)N/A1 trial
Implantable Loop Recorder InsertionN/A1 trial
Oxygen Saturation Patterns in Post-Op Patients at Risk for Obstructive Sleep ApneaN/A1 trial
end-tidal CO2N/A1 trial
Active Trials
NCT01010438Completed59Est. Dec 2011
NCT01058551Completed31Est. Sep 2019
NCT01078207Completed100Est. Oct 2010
+2 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
1
1
MontelukastPhase 4
budesonide and montelukastPhase 3
MSD
MSDIreland - Ballydine
2 programs
1
1
MontelukastPhase 41 trial
budesonide and montelukastPhase 31 trial
Active Trials
NCT01089647Completed34Est. Jun 2014
NCT01027806Terminated64Est. Aug 2014
Apnimed
ApnimedMA - Cambridge
12 programs
2
5
1
2
AD109Phase 35 trials
Aroxybutynin and AtomoxetinePhase 31 trial
AD128Phase 2/32 trials
AD036Phase 23 trials
AD113Phase 21 trial
+7 more programs
Active Trials
NCT06525337Active Not Recruiting60Est. Mar 2025
NCT05101122Completed15Est. Apr 2022
NCT03892772Completed23Est. Jul 2021
+14 more trials
Prevail Therapeutics
1 program
1
TirzepatidePhase 3Peptide
Angeles Therapeutics
6 programs
1
Acetazolamide 500 MG QHSPhase 21 trial
Continuous positive airway pressureN/A1 trial
Immediate InterventionN/A1 trial
Patient decision aidN/A1 trial
Whole Body VibrationN/A1 trial
+1 more programs
Active Trials
NCT01791270Completed80Est. Dec 2012
NCT06039865Completed50Est. Jan 2025
NCT03138993Completed36Est. Nov 2018
+3 more trials
Idorsia
IdorsiaSwitzerland - Allschwil
1 program
1
ACT-541468Phase 11 trial
Active Trials
NCT03765294Completed28Est. Nov 2019
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY2586116Phase 11 trial
Active Trials
NCT04872387Completed36Est. Aug 2021
ResMed
ResMedSAN DIEGO, CA
34 programs
APAP AN/A1 trial
Adaptive servo-ventilationN/A1 trial
ApneaLink Sleep ScreenerN/A1 trial
Auto-PAPN/A1 trial
AutoSet for HerN/A1 trial
+29 more programs
Active Trials
NCT02357706Completed20Est. Dec 2015
NCT01462084Completed21Est. Dec 2012
NCT00354614Completed81Est. Jul 2007
+31 more trials
Philips
PhilipsNetherlands - Amsterdam
9 programs
Auto AFlexN/A1 trial
Bi-FlexN/A1 trial
CPAPN/A1 trial
CPAP Fixed PressureN/A1 trial
NightBalance Sleep Position TrainerN/A1 trial
+4 more programs
Active Trials
NCT00636181Completed168Est. Mar 2009
NCT00458406Completed60Est. Apr 2012
NCT02522442Completed51Est. Jan 2009
+6 more trials
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
4 programs
Delphi Consensus Excessive Daytime Sleepiness in OSAN/A1 trial
JZP-110PHASE_21 trial
JZP-110PHASE_31 trial
JZP-110PHASE_31 trial
Active Trials
NCT05055271Completed10Est. Sep 2022
NCT02806895Completed34Est. May 2019
NCT02348619Completed174Est. Nov 2016
+1 more trials
Nyxoah
4 programs
GenioN/A1 trial
Genio® system therapyN/A1 trial
Genio™ systemN/A1 trial
Nyxoah SAT systemN/A1 trial
Active Trials
NCT03763682Terminated42Est. Jun 2024
NCT04031040Active Not Recruiting110Est. Oct 2030
NCT03868618Active Not Recruiting115Est. Feb 2028
+1 more trials
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
3 programs
Forced DesynchronyN/A1 trial
Sleep EndoscopyN/A1 trial
Sleep studyN/A1 trial
Active Trials
NCT02202811Completed39Est. Mar 2020
NCT02693977Completed347Est. Mar 2023
NCT03771469Active Not Recruiting81Est. Jan 2027
Teva
TevaIsrael - Petach Tikva
3 programs
PolysomnogramN/A1 trial
Armodafinil 150 mg/dayPHASE_31 trial
Armodafinil 250 mg/dayPHASE_31 trial
Active Trials
NCT01340781Completed110Est. Feb 2013
NCT00079677Completed263Est. Oct 2004
NCT00078325Completed395Est. Nov 2004
Sommetrics
SommetricsCA - San Diego
3 programs
aerSleep IIN/A1 trial
cNEPN/A1 trial
continuous negative external pressureN/A1 trial
Active Trials
NCT05608486Available
NCT03375905Completed8Est. Apr 2019
NCT03108417Withdrawn0Est. Sep 2018
LivaNova
LivaNovaUK - London
2 programs
Hypoglossal Nerve StimulationN/A1 trial
aura6000 SystemN/A1 trial
Active Trials
NCT04950894Active Not Recruiting150Est. Oct 2025
NCT02263859Completed138Est. Sep 2023
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
Inspiratory Muscle Strength TrainingN/A1 trial
Obstructive sleep apnea testingN/A1 trial
Active Trials
NCT04932447Active Not Recruiting122Est. Sep 2026
NCT04922112Withdrawn0Est. Sep 2022
Arctic Therapeutics
Arctic TherapeuticsIceland - Reykjavik
1 program
3D acquisition of maxillofacial characteristicsN/A1 trial
Active Trials
NCT03632382Completed280Est. Sep 2020
Innovation Pharmaceuticals
1 program
Active CPAPN/A1 trial
Active Trials
NCT01850992Withdrawn0Est. Aug 2015
Great Lakes NeuroTechnologies
1 program
Autoadjusting CPAPN/A
Laurent Pharmaceuticals
1 program
CSR remote monitoringN/A
Advanced Brain Monitoring
1 program
Deliver therapy when the supine position is detectedN/A1 trial
Active Trials
NCT02032706Completed36Est. Feb 2014
Oxitone Medical
Oxitone MedicalIsrael - Kfar Saba
1 program
Patient wears a wrist sensor oximeter device for one to two nights.N/A1 trial
Active Trials
NCT04018547Unknown30Est. Dec 2019
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
1 program
Sleep Apnea in Look AHEAD (Action for Health in Diabetes)N/A1 trial
Active Trials
NCT00194259Unknown320Est. Jun 2014
Boston Scientific
Boston ScientificCA - Valencia
1 program
Sleep and Stent Study: a Multicentre, Prospective StudyN/A1 trial
Active Trials
NCT02215317Completed1,815Est. Sep 2015
Somnetics
SomneticsMN - Fridley
1 program
Somnetics Transcend AutoN/A1 trial
Active Trials
NCT01799265Completed41Est. Jun 2013
Dong-A ST
Dong-A STKorea - Seoul
1 program
WATCH-PATN/A1 trial
Active Trials
NCT03600246Completed100Est. Jul 2020
Takeda
TakedaTOKYO, Japan
1 program
TAK-925PHASE_11 trial
Active Trials
NCT04091425Completed25Est. Apr 2020
Mineralys Therapeutics
1 program
LorundrostatPHASE_2Small Molecule1 trial
Active Trials
NCT06785454Completed48Est. Dec 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
PhilipsCPAP
Inspire Medical SystemsInspire® Upper Airway Stimulation
Inspire Medical SystemsInspire® Upper Airway Stimulation
MSDMontelukast
MedtronicPillar Palatal Implants
ApnimedAroxybutynin and Atomoxetine
ApnimedAD109
ApnimedAD109
ResMedS9 VPAP Adapt
Jazz PharmaceuticalsJZP-110
Jazz PharmaceuticalsJZP-110
MSDbudesonide and montelukast
Inspire Medical SystemsInspire Upper Airway Stimulation System
TevaArmodafinil 150 mg/day
TevaArmodafinil 250 mg/day

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 8,564 patients across 50 trials

NCT03936751PhilipsCPAP

Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: CPAP-CARE STUDY.

Start: Apr 2019Est. completion: Dec 2022150 patients
Phase 4Terminated
NCT02675816Inspire Medical SystemsInspire® Upper Airway Stimulation

Inspire® Upper Airway Stimulation System

Start: Aug 2015Est. completion: Jul 201616 patients
Phase 4Terminated
NCT02293746Inspire Medical SystemsInspire® Upper Airway Stimulation

Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study

Start: Jun 2014Est. completion: Jan 201760 patients
Phase 4Completed
NCT01027806MSDMontelukast

Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children

Start: Jul 2010Est. completion: Aug 201464 patients
Phase 4Terminated
NCT00307957MedtronicPillar Palatal Implants

Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea

Start: Oct 2005Est. completion: Oct 2006100 patients
Phase 4Completed
NCT06566820ApnimedAroxybutynin and Atomoxetine

Continuation Protocol for Obstructive Sleep Apnea (OSA)

Start: Jul 2024Est. completion: Jun 20261,280 patients
Phase 3Enrolling By Invitation
NCT05813275ApnimedAD109

Parallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study)

Start: Sep 2023Est. completion: Mar 2025646 patients
Phase 3Completed
NCT05811247ApnimedAD109

Parallel Arm Trial of AD109 and Placebo With Patients With OSA (LunAIRo)

Start: Aug 2023Est. completion: May 2025660 patients
Phase 3Completed
NCT04084990ResMedS9 VPAP Adapt

Sleep Apnea and Fetal Growth Restriction

Start: Nov 2019Est. completion: Jul 20213 patients
Phase 3Terminated
NCT02348606Jazz PharmaceuticalsJZP-110

"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"

Start: May 2015Est. completion: Dec 2016476 patients
Phase 3Completed
NCT02348619Jazz PharmaceuticalsJZP-110

"Six-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"

Start: May 2015Est. completion: Nov 2016174 patients
Phase 3Completed
NCT01089647MSDbudesonide and montelukast

Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)

Start: Sep 2010Est. completion: Jun 201434 patients
Phase 3Completed
NCT01161420Inspire Medical SystemsInspire Upper Airway Stimulation System

Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)

Start: Jul 2010Est. completion: Apr 2017929 patients
Phase 3Completed
NCT00079677TevaArmodafinil 150 mg/day

Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea (OSA/H) Syndrome

Start: Mar 2004Est. completion: Oct 2004263 patients
Phase 3Completed
NCT00078325TevaArmodafinil 250 mg/day

Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome(OSAHS)

Start: Feb 2004Est. completion: Nov 2004395 patients
Phase 3Completed
NCT04394143ApnimedAD128

Effect of AD128 to Treat Obstructive Sleep Apnea

Start: Oct 2020Est. completion: Jul 202115 patients
Phase 2/3Completed
NCT06785454Mineralys TherapeuticsLorundrostat

A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension

Start: Feb 2025Est. completion: Dec 202548 patients
Phase 2Completed
NCT06400615ApnimedAD109

Study That Tests AD109 in Patients Taking GLP-1 Drugs

Start: May 2024Est. completion: Dec 202440 patients
Phase 2Completed
NCT05953610Angeles TherapeuticsAcetazolamide 500 MG QHS

Endotypic Traits and Obstructive Sleep Apnea Surgery

Start: Jan 2024Est. completion: Aug 2028150 patients
Phase 2Recruiting
NCT05793684ApnimedAD816

AD816 Crossover Study

Start: Apr 2023Est. completion: Nov 202325 patients
Phase 2Completed
NCT05071612ApnimedAD109

Parallel Arm Trial of AD109 and AD504 In Patients With OSA

Start: Nov 2021Est. completion: Aug 2022294 patients
Phase 2Completed
NCT04905979ApnimedAD113

Trial of AD113 and Atomoxetine in OSA Patients With Hypertension

Start: Jul 2021Est. completion: May 202321 patients
Phase 2Completed
NCT04631107ApnimedAD109

AD109 Dose Finding in Mild to Moderate OSA

Start: Dec 2020Est. completion: May 202132 patients
Phase 2Completed
NCT04611750ApnimedAD036

Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing

Start: Dec 2020Est. completion: Jan 202253 patients
Phase 2Completed
NCT04645524ApnimedAD182

Crossover Trial of AD182 and AD504 in Obstructive Sleep Apnea

Start: Dec 2020Est. completion: Sep 202115 patients
Phase 2Completed
NCT04580394ApnimedAD109

Crossover Trial of AD109 in Obstructive Sleep Apnea

Start: Oct 2020Est. completion: May 202160 patients
Phase 2Completed
NCT04445688ApnimedAD036

Crossover Trial of AD036 in Obstructive Sleep Apnea

Start: Jul 2020Est. completion: Dec 202062 patients
Phase 2Completed
NCT04449133ApnimedAD128

Study of AD128 Versus Placebo in Obstructive Sleep Apnea

Start: Jul 2020Est. completion: Oct 202020 patients
Phase 2Completed
NCT03845023ApnimedAD036

Trial of AD036 in Obstructive Sleep Apnea

Start: Mar 2019Est. completion: Oct 2019140 patients
Phase 2Completed
NCT02806895Jazz PharmaceuticalsJZP-110

Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in OSA

Start: Jul 2016Est. completion: May 201934 patients
Phase 2Completed
NCT01395693ResMedSalt Lake mask system

Performance of the Salt Lake Mask System

Start: Jun 2011Est. completion: Jul 201120 patients
Phase 2Completed
NCT05101122ApnimedAD313

Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED)

Start: Oct 2021Est. completion: Apr 202215 patients
Phase 1/2Completed
NCT03892772ApnimedSAS0421

Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea

Start: Jan 2019Est. completion: Jul 202123 patients
Phase 1/2Completed
NCT04872387BayerBAY2586116

A Study to Learn More About How Safe BAY2586116 is, How it Affects the Body, How it Moves Into, Through and Out of the Body at Different Doses in Healthy Japanese Male Participants After Taking Single and Multiple Doses Through the Nose

Start: May 2021Est. completion: Aug 202136 patients
Phase 1Completed
NCT04091425TakedaTAK-925

Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP)

Start: Nov 2019Est. completion: Apr 202025 patients
Phase 1Completed
NCT03765294IdorsiaACT-541468

A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Moderate Obstructive Sleep Apnea

Start: Mar 2019Est. completion: Nov 201928 patients
Phase 1Completed
NCT05608486SommetricsaerSleep II

Continuation Protocol for Study Using Negative Pressure to Reduce Apnea Trial

N/AAvailable
NCT06562205ResMedPAP System A

PAP Systems External Clinical Studies (ECS)

Start: Aug 2028Est. completion: Oct 202830 patients
N/ANot Yet Recruiting
NCT07485582ResMedDevice A

Exploration of Current and New Technologies for Accuracy of Diagnosing OSA

Start: Apr 2026Est. completion: Oct 202690 patients
N/ANot Yet Recruiting
NCT06971796Inspire Medical SystemsInspire UAS System

EURO-STIM Registry

Start: May 2025Est. completion: Apr 20351,000 patients
N/ARecruiting
NCT06769607ResMedInvestigational algorithm

Evaluation of a Novel Auto-Adjusting Positive Airway Pressure Algorithm for the Treatment of Obstructive Sleep Apnea Clinical Study

Start: Apr 2025Est. completion: Dec 202580 patients
N/ARecruiting
NCT05255744ResMedPositive Airway Pressure

Whitsundays (Nasal) Singapore External Clinical Study 1 Protocol

Start: Mar 2025Est. completion: May 202530 patients
N/ATerminated
NCT06525337ApnimedSTANDARDCARE

Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes

Start: Aug 2024Est. completion: Mar 202560 patients
N/AActive Not Recruiting
NCT06540716Inspire Medical SystemsInspire System

Inspire Singapore Study

Start: Aug 2024Est. completion: Dec 202544 patients
N/ARecruiting
NCT06173050ResMedPAP System A

PAP Systems Internal Clinical Studies (ICS)

Start: Jun 2024Est. completion: Jul 202430 patients
N/ACompleted
NCT06039865Angeles TherapeuticsImmediate Intervention

Chronic Care Management With Wearable Devices in Patients Prescribed Positive Airway Pressure Therapy (mPAP) Trial

Start: Oct 2023Est. completion: Jan 202550 patients
N/ACompleted
NCT06079866ResMedMask A

Oran Park Mask External Clinical Study (3) Marketing Claims Study

Start: Oct 2023Est. completion: Nov 202358 patients
N/ACompleted
NCT06036329ResMedGroup A : provided with 1 Whitsundays Nasal mask without a spare mask cushion

Whitsundays (Nasal) Mask Take Home Study (90 Days)

Start: May 2023Est. completion: Nov 2023120 patients
N/ACompleted
NCT05376137ResMedcontinuous positive airway pressure

Personal Therapy Comfort Settings Pilot Clinical Study

Start: Sep 2022Est. completion: Sep 202366 patients
N/ACompleted
NCT05262439ResMedNew generation CPAP mask

Post Market Clinical Follow up of ResMed Mask Systems

Start: May 2022Est. completion: Jun 2027500 patients
N/ARecruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals
5 actively recruiting trials targeting 8,564 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.