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Obsessive-Compulsive Disorder

8
Pipeline Programs
17
Companies
28
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
4
0
1
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
3100%
+ 26 programs with unclassified modality

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
pregabalinPhase 41 trial
Active Trials
NCT00994786Completed15Est. Jan 2019
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
6 programs
1
1
MemantinePhase 31 trial
D-CycloserinePhase 21 trial
Cognitive Behavioral TherapyN/A1 trial
Exposure and Response PreventionN/A1 trial
Individual Child CBTN/A1 trial
+1 more programs
Active Trials
NCT00748761Completed119Est. Dec 2016
NCT03601312Completed27Est. Aug 2021
NCT01409642Completed62Est. Dec 2016
+3 more trials
Medtronic
MedtronicNJ - Phillipsburg
5 programs
1
Medtronic Activa Deep Brain StimulationPhase 21 trial
Activa PC+S DBS implant for OCDN/A1 trial
Medtronic Restore Advanced 37713N/A1 trial
Summit RC+S SystemN/A1 trial
Summit RC+S System with ECoG PaddlesN/A1 trial
Active Trials
NCT03457675Active Not Recruiting2Est. Jun 2027
NCT02685280Completed12Est. Dec 2014
NCT04281134Active Not Recruiting3Est. Jun 2027
+2 more trials
Neurocrine Biosciences
1 program
1
ValbenazinePhase 21 trial
Active Trials
NCT07111988Not Yet Recruiting30Est. Dec 2027
Alliance Pharmaceuticals
1 program
1
ketaminePhase 21 trial
Active Trials
NCT01349231Completed10Est. Dec 2011
Pins Medical
Pins MedicalChina - Beijing
2 programs
1
Deep Brain StimulationPhase 11 trial
Deep Brain stimulationN/A1 trial
Active Trials
NCT06542224Recruiting16Est. Dec 2026
NCT02253472Unknown30Est. Dec 2018
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
Pramipexole, AmisulpridePhase 1
Biohaven
BiohavenNEW HAVEN, CT
3 programs
TroriluzolePHASE_2_3Small Molecule1 trial
TroriluzolePHASE_3Small Molecule1 trial
TroriluzolePHASE_3Small Molecule1 trial
Active Trials
NCT03299166Completed426Est. Dec 2025
NCT04693351Completed589Est. Apr 2025
NCT04641143Completed456Est. Oct 2025
BrainsWay
BrainsWayJerusalem, Israel
2 programs
BrainsWay Deep TMS HAC/H7-CoilN/A1 trial
BrainsWay Deep TMS HAC/H7-CoilN/A1 trial
Active Trials
NCT07116785Recruiting50Est. Dec 2028
NCT05404360Unknown124Est. Jun 2024
Eppendorf
EppendorfGermany - Hamburg
1 program
"association splitting"N/A1 trial
Active Trials
NCT01035242Completed156Est. Jul 2012
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Light therapyN/A1 trial
Active Trials
NCT05391503Completed21Est. Aug 2024
Jerusalem Pharmaceuticals
Jerusalem PharmaceuticalsIsrael - Ramallah
1 program
Personalized Computer ProgramN/A1 trial
Active Trials
NCT03855943Unknown100Est. Jun 2024
Innovation Pharmaceuticals
1 program
Use of esTOCmaN/A1 trial
Active Trials
NCT06334887Completed175Est. Jun 2024
Varian Medical Systems
1 program
fMRI and DTIN/A1 trial
Active Trials
NCT04688554Completed18Est. Feb 2024
GSK
GSKLONDON, United Kingdom
1 program
Pramipexole, AmisulpridePHASE_11 trial
Active Trials
NCT00471588Completed52Est. Dec 2007
UCB Pharma
UCB PharmaBelgium - Brussels
1 program
SertralinePHASE_2_31 trial
Active Trials
NCT00299611Terminated12Est. Apr 2008

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Pfizerpregabalin
BiohavenTroriluzole
BiohavenTroriluzole
Angeles TherapeuticsMemantine
BiohavenTroriluzole
UCB PharmaSertraline
Neurocrine BiosciencesValbenazine
Angeles TherapeuticsD-Cycloserine
Alliance Pharmaceuticalsketamine
MedtronicMedtronic Activa Deep Brain Stimulation
Pins MedicalDeep Brain Stimulation
GSKPramipexole, Amisulpride
Pins MedicalDeep Brain stimulation
Innovation PharmaceuticalsUse of esTOCma
BrainsWayBrainsWay Deep TMS HAC/H7-Coil

Showing 15 of 28 trials with date data

Clinical Trials (28)

Total enrollment: 2,566 patients across 28 trials

NCT00994786Pfizerpregabalin

A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder

Start: Jan 2009Est. completion: Jan 201915 patients
Phase 4Completed
NCT04693351BiohavenTroriluzole

Efficacy and Safety Study of Adjunctive Troriluzule in Obsessive Compulsive Disorder

Start: Jan 2021Est. completion: Apr 2025589 patients
Phase 3Completed
NCT04641143BiohavenTroriluzole

Efficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder

Start: Dec 2020Est. completion: Oct 2025456 patients
Phase 3Completed
NCT00674219Angeles TherapeuticsMemantine

Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder

Start: May 2005Est. completion: Jan 200817 patients
Phase 3Completed
NCT03299166BiohavenTroriluzole

Troriluzole (BHV-4157) in Adult Participants With Obsessive Compulsive Disorder

Start: Dec 2017Est. completion: Dec 2025426 patients
Phase 2/3Completed
NCT00299611UCB PharmaSertraline

Augmentation Study of Levetiracetam in Obsessive Compulsive Disorder

Start: Nov 2005Est. completion: Apr 200812 patients
Phase 2/3Terminated
NCT07111988Neurocrine BiosciencesValbenazine

Valbenazine in Obsessive Compulsive Disorder

Start: May 2026Est. completion: Dec 202730 patients
Phase 2Not Yet Recruiting
NCT01687140Angeles TherapeuticsD-Cycloserine

The Use of D-Cycloserine to Augment CBT for Pediatric OCD

Start: Jul 2012Est. completion: Jul 201426 patients
Phase 2Unknown
NCT01349231Alliance Pharmaceuticalsketamine

Ketamine Infusion for Obsessive-Compulsive Disorder

Start: Feb 2009Est. completion: Dec 201110 patients
Phase 2Completed
NCT01061983MedtronicMedtronic Activa Deep Brain Stimulation

Electrical Stimulation of the Internal Capsule for Intractable Obsessive-compulsive Disorder (OCD)

Start: Jan 2001Est. completion: Oct 20125 patients
Phase 2Completed
NCT02253472Pins MedicalDeep Brain Stimulation

The Safety and Efficacy of Long-term Treatment of PINS Stimulator System for Patients With Obsessive-Compulsive Disorder

Start: Dec 2016Est. completion: Dec 201830 patients
Phase 1Unknown
NCT00471588GSKPramipexole, Amisulpride

Characterize The Modulatory Effects Of Dopamine D2/D3 Receptor Agonist And Antagonist Drugs On Compulsive Behaviors

Start: Aug 2006Est. completion: Dec 200752 patients
Phase 1Completed
NCT06542224Pins MedicalDeep Brain stimulation

Identifying Local Field Potential Biomarkers for Obsessive-compulsive Disorder Treatment With Deep Brain Stimulation

Start: Aug 2024Est. completion: Dec 202616 patients
N/ARecruiting
NCT06334887Innovation PharmaceuticalsUse of esTOCma

esTOCma, an App Used by Teachers: an RCT

Start: Feb 2024Est. completion: Jun 2024175 patients
N/ACompleted
NCT07116785BrainsWayBrainsWay Deep TMS HAC/H7-Coil

Accelerated Rotational Field Deep TMS for Treating OCD

Start: Sep 2023Est. completion: Dec 202850 patients
N/ARecruiting
NCT05391503Colorado TherapeuticsLight therapy

Light Therapy for Obsessive-compulsive Disorder (OCD)

Start: Sep 2022Est. completion: Aug 202421 patients
N/ACompleted
NCT05404360BrainsWayBrainsWay Deep TMS HAC/H7-Coil

Evaluation of the Long Term Efficacy and Durability of the BrainsWay Deep TMS in OCD Subjects

Start: Aug 2022Est. completion: Jun 2024124 patients
N/AUnknown
NCT04806516MedtronicSummit RC+S System with ECoG Paddles

Phase II Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder

Start: Jul 2021Est. completion: Jul 20265 patients
N/AActive Not Recruiting
NCT04688554Varian Medical SystemsfMRI and DTI

Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease

Start: Aug 2020Est. completion: Feb 202418 patients
N/ACompleted
NCT04281134MedtronicSummit RC+S System

Development of Adaptive Deep Brain Stimulation for OCD

Start: Oct 2019Est. completion: Jun 20273 patients
N/AActive Not Recruiting
NCT03855943Jerusalem PharmaceuticalsPersonalized Computer Program

Evaluating the Effects of a Computerized Training Program Coupled With Cognitive Behavioral Therapy (CBT) for OCD.

Start: Apr 2019Est. completion: Jun 2024100 patients
N/AUnknown
NCT03601312Angeles TherapeuticsExposure and Response Prevention

Randomized Controlled Trial of Standard ERP and OC-Go

Start: Nov 2018Est. completion: Aug 202127 patients
N/ACompleted
NCT03457675MedtronicActiva PC+S DBS implant for OCD

Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)

Start: Jul 2018Est. completion: Jun 20272 patients
N/AActive Not Recruiting
NCT03126305Angeles TherapeuticsOC-Go

Initial Development and Dissemination of OC-Go

Start: May 2017Est. completion: Apr 20188 patients
N/ACompleted
NCT01035242Eppendorf"association splitting"

"Association Splitting" in Obsessive-Compulsive Disorder (OCD)

Start: Mar 2009Est. completion: Jul 2012156 patients
N/ACompleted
NCT00748761Angeles TherapeuticsCognitive Behavioral Therapy

Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder

Start: Jun 2008Est. completion: Dec 2016119 patients
N/ACompleted
NCT01409642Angeles TherapeuticsIndividual Child CBT

Family Focused Treatment of Pediatric Obsessive Compulsive Disorder

Start: Jan 2008Est. completion: Dec 201662 patients
N/ACompleted
NCT02685280MedtronicMedtronic Restore Advanced 37713

Rechargeable Neurostimulators in Deep Brain Stimulation for Psychiatric Disorders

Start: Oct 2007Est. completion: Dec 201412 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 2,566 patients
17 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.