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Neurogenic Detrusor Overactivity

4
Pipeline Programs
4
Companies
29
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
mirabegronPhase 35 trials
Active Trials
NCT05621616Active Not Recruiting7Est. Sep 2026
NCT04562090Completed249Est. Mar 2022
NCT04501640Completed24Est. Oct 2020
+2 more trials
EG 427
EG 427France - Paris
1 program
1
EG110APhase 1/21 trial
Active Trials
NCT06596291Recruiting16Est. Jun 2027
Pfizer
PfizerNEW YORK, NY
2 programs
2
4 mg Fesoterodine ER tablet from ZwickauPhase 11 trial
Fesoterodine BIC SR4 fastedPhase 11 trial
Active Trials
NCT04478357Completed18Est. Nov 2020
NCT04452838Completed37Est. Jan 2021
Recordati
RecordatiFrance - Saint-Victor
1 program
Rec 0/0438 1 mg or Rec 0/0438 2 mgPHASE_1_21 trial
Active Trials
NCT03482037Completed42Est. Mar 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
Astellasmirabegron
EG 427EG110A
RecordatiRec 0/0438 1 mg or Rec 0/0438 2 mg
Astellasmirabegron
PfizerFesoterodine BIC SR4 fasted
Pfizer4 mg Fesoterodine ER tablet from Zwickau

Showing 15 of 29 trials with date data

Clinical Trials (29)

Total enrollment: 10,799 patients across 29 trials

A Study With Mirabegron 50 mg and 25 mg in Chinese Participants With Overactive Bladder

Start: Jan 2021Est. completion: Mar 2022249 patients
Phase 4Completed

A Study to Investigate the Effect of Food With Mirabegron in Healthy Chinese Participants

Start: Sep 2020Est. completion: Oct 202024 patients
Phase 4Completed

Mirabegron for the Treatment of Pain Motivated Urinary Frequency and Urgency in Women

Start: Dec 2017Est. completion: Jun 20180
Phase 4Withdrawn

Mirabegron and Urinary Urgency Incontinence

Start: Jan 2015Est. completion: Jan 201984 patients
Phase 4Completed

Postmarketing Study to Evaluate add-on Therapy With Anticholinergics in Patients With Overactive Bladder (OAB) on Mirabegron.

Start: Oct 2014Est. completion: Sep 2016649 patients
Phase 4Completed

A Study to Evaluate Tolerability and Participants Preference Between Mirabegron and Tolterodine Extended Release (ER) in Participants With Overactive Bladder (OAB)

Start: Jul 2014Est. completion: Nov 2015376 patients
Phase 4Completed

Post-marketing Study to Evaluate the Effect of Mirabegron on the Plasma Concentration of Tolterodine

Start: Jun 2013Est. completion: Aug 201324 patients
Phase 4Completed

A Study to Evaluate the Effect of Mirabegron + Solifenacin in Overactive Bladder Patients

Start: Oct 2012Est. completion: Jul 2013223 patients
Phase 4Completed

A Study to Learn How Effective and Safe the Drug 'Mirabegron' is and How Long it Stays in the Body of Children Aged 6 Months to Less Than 3 Years of Age With Neurogenic Detrusor Overactivity

Start: Feb 2024Est. completion: Sep 20267 patients
Phase 3Active Not Recruiting

Open-label Phase 3 Study With Mirabegron in Children From 3 to Less Than 18 Years of Age With Neurogenic Detrusor Overactivity

Start: Jun 2016Est. completion: May 201991 patients
Phase 3Completed

Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization

Start: Jan 2025Est. completion: Jun 202716 patients
Phase 1/2Recruiting
NCT03482037RecordatiRec 0/0438 1 mg or Rec 0/0438 2 mg

Effects of Rec 0/0438 in Patients With Neurogenic Detrusor Overactivity Due to Spinal Cord Injury

Start: Jun 2018Est. completion: Mar 201942 patients
Phase 1/2Completed

Mirabegron For Erectile Dysfunction

Start: Aug 2017Est. completion: Jan 202020 patients
Phase 1/2Completed
NCT04452838PfizerFesoterodine BIC SR4 fasted

Study To Assess The Bioequivalence Under Fed And Fasted Conditions Of The Fesoterodine Beads-In-Capsule SR4 And SR7 Formulations And To Estimate The Bioavailability of SR7 Beads Sprinkled On Apple Sauce Relative To The Beads-In-Capsule SR7 Formulation Administer

Start: Jun 2020Est. completion: Jan 202137 patients
Phase 1Completed
NCT04478357Pfizer4 mg Fesoterodine ER tablet from Zwickau

BIOEQUIVALENCE STUDY IN HEALTHY PARTICIPANTS COMPARING 4 MG AND 8 MG FESOTERODINE EXTENDED-RELEASE TABLETS (TOVIAZ™), MANUFACTURED AT ZWICKAU VERSUS FREIBURG

Start: Nov 2019Est. completion: Nov 202018 patients
Phase 1Completed

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron Oral Suspension in Pediatric Subjects From 3 to Less Than 12 Years of Age With Neurogenic Detrusor Overactivity (NDO) or Overactive Bladder (OAB)

Start: Dec 2015Est. completion: Sep 20169 patients
Phase 1Completed

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron OCAS (Oral Controlled Absorption System) in Pediatric Subjects With Neurogenic Detrusor Overactivity or Overactive Bladder

Start: Sep 2014Est. completion: Sep 201534 patients
Phase 1Completed

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects

Start: Mar 2014Est. completion: Jun 201426 patients
Phase 1Completed

A Study to Evaluate Cardiovascular Interactions Between Mirabegron and Tamsulosin

Start: Aug 2010Est. completion: Feb 201148 patients
Phase 1Completed

Study of the Effect of Food on the Pharmacokinetics of Mirabegron

Start: May 2009Est. completion: Jul 200976 patients
Phase 1Completed

Pharmacokinetics of Oral Mirabegron With Different Release Rates Versus Intravenous (IV) Mirabegron

Start: Apr 2009Est. completion: Jul 200991 patients
Phase 1Completed

A Study to Evaluate How Mirabegron Enters and Leaves the Bloodstream According to Age and Sex

Start: Mar 2009Est. completion: Nov 200975 patients
Phase 1Completed

A Study to Find Out How Much Mirabegron Gets Into the Body After Dosing With a Tablet Formulation

Start: Feb 2006Est. completion: Mar 200612 patients
Phase 1Completed

Treatment Persistence Among Patients With Overactive Bladder: A Retrospective Secondary Data Analysis in Asia Oceania

Start: Jul 2018Est. completion: Sep 20195,589 patients
N/ACompleted

A Registry Study of Patients Initiating a Course of Drug Therapy for Overactive Bladder in Taiwan, Korea and China

Start: Jul 2018Est. completion: Mar 2020805 patients
N/ACompleted

Myrbetriq™ (Mirabegron) to Improve Disordered Sleep in Subjects With Lower Urinary Tract Symptoms (LUTS)

Start: Apr 2015Est. completion: Dec 201834 patients
N/ACompleted

A Prospective, Observational, Multicenter Study of Patients Following Initiation of a New Course of Treatment for Overactive Bladder (OAB)

Start: Jan 2015Est. completion: Aug 20171,524 patients
N/ACompleted

Specified Drug Use-results Survey of Betanis Tablets

Start: Dec 2012Est. completion: Jan 2018300 patients
N/ACompleted

Specified Drug Use-results Survey of Betanis Tablets for Patients With Coexisting Cardiovascular Disease

Start: Dec 2012Est. completion: Mar 2015316 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 10,799 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.