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Nausea and Vomiting, Chemotherapy-Induced

12
Pipeline Programs
2
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
9
0
1
0
2
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 19 programs with unclassified modality

Competitive Landscape

2 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
12 programs
9
1
2
CasopitantPhase 3
Oral CasopitantPhase 3
GW679769Phase 2
CasopitantPhase 1
CasopitantPhase 1
+7 more programs
GSK
GSKLONDON, United Kingdom
8 programs
CasopitantPHASE_11 trial
CasopitantPHASE_11 trial
DocetaxelPHASE_11 trial
GW679769PHASE_11 trial
Oral GW679769PHASE_11 trial
+3 more programs
Active Trials
NCT00404274Completed97Est. Mar 2007
NCT00437229Completed37Est. May 2007
NCT00440128Completed12Est. Jul 2008
+5 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKOral Casopitant
GSKGW679769
GSKcasopitant
GSKDocetaxel
GSKCasopitant
GSKGW679769
GSKCasopitant
GSKOral GW679769

Clinical Trials (8)

Total enrollment: 1,731 patients across 8 trials

NCT00431236GSKOral Casopitant

A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy

Start: Nov 2006Est. completion: Oct 2007810 patients
Phase 3Completed

Study Of Prevention of Chemo-Induced Nausea and Vomiting Caused By Moderately Emetogenic Chemotherapy

Start: Dec 2004Est. completion: Jan 2006722 patients
Phase 2Completed
NCT00511823GSKcasopitant

The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects

Start: Jul 2007Est. completion: Sep 200716 patients
Phase 1Completed

The Effects Of GW679769 (Casopitant) On The Pharmacokinetics Of Docetaxel In Subjects With Cancer

Start: May 2007Est. completion: Jul 200812 patients
Phase 1Completed
NCT00437229GSKCasopitant

A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults

Start: Feb 2007Est. completion: May 200737 patients
Phase 1Completed

A Study in Healthy Subjects to Assess How Dosing of Rifampin Affects What the Body Does to a Dose of GW679769 (Casopitant).

Start: Nov 2006Est. completion: Jan 200712 patients
Phase 1Completed
NCT00404274GSKCasopitant

A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers

Start: Nov 2006Est. completion: Mar 200797 patients
Phase 1Completed
NCT00334646GSKOral GW679769

Cyclophosphamide Drug Interaction Study In Cancer Patients

Start: Aug 2005Est. completion: Oct 200925 patients
Phase 1Terminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
2 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.