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Nasal Congestion

5
Pipeline Programs
7
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
2
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
1
1
Test stripPhase 4
Carbon DioxidePhase 2
Ache Laboratorios Farmaceuticos
1 program
1
Diphenhydramine + Pseudoephedrine + DropropizinePhase 31 trial
Active Trials
NCT01199497Withdrawn0Est. Jan 2013
EMS
EMSBrazil - Hortolândia
1 program
1
NaridrinPhase 31 trial
Active Trials
NCT02601235Completed292Est. Apr 2019
Bayer
BayerLEVERKUSEN, Germany
1 program
1
Phenylephrine HCl Extended ReleasePhase 11 trial
Active Trials
NCT01354418Completed24Est. Jul 2011
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
Diphenhydramine hydrochloridePHASE_11 trial
Diphenhydramine 50 mgPHASE_41 trial
Active Trials
NCT00662337Completed36Est. Nov 2006
NCT00648973Completed1,021Est. May 2007
Aardvark Therapeutics
Aardvark TherapeuticsCA - San Diego
1 program
Use of an automatic nasal irrigator/aspiratorN/A1 trial
Active Trials
NCT01129765Completed30Est. Aug 2009
GSK
GSKLONDON, United Kingdom
1 program
Carbon DioxidePHASE_21 trial
Active Trials
NCT02113449Completed147Est. Feb 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Johnson & JohnsonDiphenhydramine 50 mg
EMSNaridrin
Ache Laboratorios FarmaceuticosDiphenhydramine + Pseudoephedrine + Dropropizine
GSKCarbon Dioxide
BayerPhenylephrine HCl Extended Release
Johnson & JohnsonDiphenhydramine hydrochloride
Aardvark TherapeuticsUse of an automatic nasal irrigator/aspirator

Clinical Trials (7)

Total enrollment: 1,550 patients across 7 trials

NCT00648973Johnson & JohnsonDiphenhydramine 50 mg

To Determine if Diphenhydramine Works for Nasal Congestion at Two Different Doses

Start: Nov 2006Est. completion: May 20071,021 patients
Phase 4Completed
NCT02601235EMSNaridrin

Efficacy and Safety of Pediatric Drugs in Nasal Congestion

Start: Jan 2018Est. completion: Apr 2019292 patients
Phase 3Completed
NCT01199497Ache Laboratorios FarmaceuticosDiphenhydramine + Pseudoephedrine + Dropropizine

Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis

Start: Aug 2011Est. completion: Jan 20130
Phase 3Withdrawn
NCT02113449GSKCarbon Dioxide

Market Potential of Carbon Dioxide Nasal Spray

Start: Nov 2013Est. completion: Feb 2014147 patients
Phase 2Completed
NCT01354418BayerPhenylephrine HCl Extended Release

Bioequivalence of Single Dose Phenylephrine Extended Release Tablets and Phenylephrine HCl Immediate Release Tablets Dosed Every Four Hours (P08340)(COMPLETED)

Start: May 2011Est. completion: Jul 201124 patients
Phase 1Completed
NCT00662337Johnson & JohnsonDiphenhydramine hydrochloride

Bioequivalence Between Two Oral Formulations of Diphenhydramine Hydrochloride

Start: Oct 2006Est. completion: Nov 200636 patients
Phase 1Completed
NCT01129765Aardvark TherapeuticsUse of an automatic nasal irrigator/aspirator

Home Usability of a Nasal Lavage System in Children

Start: Jul 2009Est. completion: Aug 200930 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.