Skip to main content

Mycoses

17
Pipeline Programs
9
Companies
16
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
5
0
8
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
10100%
+ 20 programs with unclassified modality

On Market (1)

Approved therapies currently available

LEUKINEApproved
sargramostim
Unknown Company
Leukocyte Growth Factor [EPC]intravenous1991
3M Part D

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Amoytop Biotech
Amoytop BiotechChina - Xiamen
2 programs
2
rhGM-CSF groupPhase 41 trial
sargramostimPhase 4
Active Trials
NCT01232504Completed206Est. Jun 2013
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
10 programs
2
3
PosaconazolePhase 3Small Molecule
Posaconazole oral suspensionPhase 3
Posaconazole oral suspensionPhase 3
PosaconazolePhase 2Small Molecule
Posaconazole oral suspensionPhase 2
+5 more programs
MSD
MSDIreland - Ballydine
10 programs
2
3
PosaconazolePhase 3Small Molecule1 trial
Posaconazole oral suspensionPhase 31 trial
Posaconazole oral suspensionPhase 31 trial
PosaconazolePhase 2Small Molecule1 trial
Posaconazole oral suspensionPhase 21 trial
+5 more programs
Active Trials
NCT02683642Completed420Est. Sep 2017
NCT00686621Approved For Marketing
NCT00726609Completed214Est. Jul 2008
+7 more trials
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
2 programs
2
VoriconazolePhase 3Small Molecule1 trial
VoriconazolePhase 3Small Molecule1 trial
Active Trials
NCT00001757Completed20Est. Jul 2000
NCT00015665Completed40Est. Mar 2003
Astellas
AstellasChina - Shenyang
1 program
1
micafunginPhase 21 trial
Active Trials
NCT01122368Completed252Est. Dec 2011
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
Terbinafine 250 mgPhase 1
Merck & Co.
Merck & Co.RAHWAY, NJ
2 programs
Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and OutcomeN/A
Standard CareN/A
GSK
GSKLONDON, United Kingdom
1 program
Terbinafine 250 mgPHASE_11 trial
Active Trials
NCT01772212Completed30Est. Mar 2011
Scynexis
ScynexisJERSEY CITY, NJ
1 program
SCY-078PHASE_21 trial
Active Trials
NCT02244606Completed27Est. Aug 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Amoytop BiotechrhGM-CSF group
MSDPosaconazole oral suspension
Allergy TherapeuticsVoriconazole
MSDPosaconazole oral suspension
MSDPosaconazole
Allergy TherapeuticsVoriconazole
ScynexisSCY-078
Astellasmicafungin
MSDPosaconazole
MSDPosaconazole oral suspension
GSKTerbinafine 250 mg
MSDInvasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome
MSDStandard Care
MSDPosaconazole or alternative fungal treatment
MSDPosaconazole

Clinical Trials (16)

Total enrollment: 2,413 patients across 16 trials

Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT

Start: Sep 2009Est. completion: Jun 2013206 patients
Phase 4Completed
NCT00034632MSDPosaconazole oral suspension

Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)

Start: Apr 2001Est. completion: Mar 2007
Phase 3Completed

Emergency Use of Voriconazole in Patients With Life-Threatening Invasive Fungal Infections

Start: Apr 2001Est. completion: Mar 200340 patients
Phase 3Completed
NCT00034645MSDPosaconazole oral suspension

Prophylaxis Trial in High Risk Allogenic Stem Cell Transplant Recipients With Graft vs. Host Disease

Start: Jan 1999Est. completion: Feb 2003600 patients
Phase 3Completed
NCT00034658MSDPosaconazole

Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)

Start: Dec 1998Est. completion: Mar 2002336 patients
Phase 3Completed

An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections

Start: Nov 1997Est. completion: Jul 200020 patients
Phase 3Completed

Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis

Start: Sep 2014Est. completion: Aug 201627 patients
Phase 2Completed

A Study to Evaluate Pre-emptive Treatment for Invasive Candidiasis in High Risk Surgical Subjects

Start: Jul 2010Est. completion: Dec 2011252 patients
Phase 2Completed
NCT00550732MSDPosaconazole

A Study to Examine the Efficacy and Safety of Posaconazole When Introduced Early in the Treatment of Refractory Fungal Infections (P05090 AM2)

Start: Dec 2007Est. completion: Nov 201240 patients
Phase 2Completed
NCT00034671MSDPosaconazole oral suspension

PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)

Start: Jan 2001Est. completion: Mar 200298 patients
Phase 2Completed
NCT01772212GSKTerbinafine 250 mg

Bioequivalence Study for Terbinafine 250 mg

Start: Feb 2011Est. completion: Mar 201130 patients
Phase 1Completed
NCT00686621MSDPosaconazole

Single Patient Treatment of Posaconazole in Invasive Fungal Infections (Study P05113)

N/AApproved For Marketing
NCT02683642MSDInvasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome

Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome

Start: Apr 2016Est. completion: Sep 2017420 patients
N/ACompleted
NCT01254318MSDStandard Care

Assessment of the Fungal Infection Incidence Across Canada for High Risk Participants With Hematological Disease (P07501)

Start: Mar 2013Est. completion: Nov 2014130 patients
N/ACompleted
NCT00704951MSDPosaconazole or alternative fungal treatment

Evaluation of Treatment and Prophylaxis of Invasive Fungal Infections in Immuncompromised Patients in Austria (Study P05532)(WITHDRAWN)

Start: Jul 2008Est. completion: Jun 20110
N/AWithdrawn
NCT00726609MSDPosaconazole

Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641)

Start: Jan 2006Est. completion: Jul 2008214 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

8 late-stage (Phase 3) programs, potential near-term approvals
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.