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Musculoskeletal Pain

4
Pipeline Programs
10
Companies
12
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
2
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 12 programs with unclassified modality

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
1 program
1
LumiracoxibPhase 4Small Molecule1 trial
Active Trials
NCT00170898Completed419
EMS
EMSBrazil - Hortolândia
2 programs
2
ketoprofen and cyclobenzaprine associationPhase 31 trial
ketoprofen and cyclobenzaprine association with caffeinePhase 31 trial
Active Trials
NCT03025113Completed416Est. Mar 2020
NCT02862977Completed414Est. Dec 2019
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
Pain Catastrophizing InductionPhase 11 trial
Active Trials
NCT00823147Completed93Est. Sep 2014
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
3 programs
Emotional Awareness and Expression TherapyN/A1 trial
Emotional Awareness and Expression TherapyN/A1 trial
Emotional Awareness and Expression TherapyN/A1 trial
Active Trials
NCT03844880Completed64Est. Aug 2019
NCT04552860Completed16Est. Aug 2021
NCT07218757Recruiting84Est. Jul 2027
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Direct access to a PTN/A1 trial
Active Trials
NCT04009369Completed78Est. Jun 2019
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Emotional Awareness and Expression TherapyN/A
Applied Medical
Applied MedicalCA - Rancho Santa Margarita
1 program
Multidisciplinary Primary Rehabilitation CareN/A1 trial
Active Trials
NCT05530902Unknown1,400Est. Feb 2026
Lundbeck
LundbeckDenmark - Copenhagen
1 program
Nerve Growth FactorN/A1 trial
Active Trials
NCT04457466Terminated100Est. Jul 2020
Relief Therapeutics
Relief TherapeuticsSwitzerland - Geneva
1 program
Signal Relief PatchN/A1 trial
Active Trials
NCT05288114Completed44Est. Sep 2022
Daehwa Pharmaceutical
Daehwa PharmaceuticalKorea - Gangwon
1 program
DHP2306R1PHASE_11 trial
Active Trials
NCT06395155Completed54Est. Dec 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
SandozLumiracoxib
EMSketoprofen and cyclobenzaprine association
EMSketoprofen and cyclobenzaprine association with caffeine
Daehwa PharmaceuticalDHP2306R1
Oregon TherapeuticsPain Catastrophizing Induction
Angeles TherapeuticsEmotional Awareness and Expression Therapy
Applied MedicalMultidisciplinary Primary Rehabilitation Care
Relief TherapeuticsSignal Relief Patch
Angeles TherapeuticsEmotional Awareness and Expression Therapy
Integrated BiosciencesDirect access to a PT
Angeles TherapeuticsEmotional Awareness and Expression Therapy
LundbeckNerve Growth Factor

Clinical Trials (12)

Total enrollment: 3,182 patients across 12 trials

Safety and Efficacy of Lumiracoxib Versus Naproxen in Acute Musculoskeletal Pain

Start: Nov 2004419 patients
Phase 4Completed
NCT03025113EMSketoprofen and cyclobenzaprine association

Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine in Osteomuscular Treatment

Start: Mar 2018Est. completion: Mar 2020416 patients
Phase 3Completed
NCT02862977EMSketoprofen and cyclobenzaprine association with caffeine

Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment

Start: Nov 2017Est. completion: Dec 2019414 patients
Phase 3Completed

A Phase 1 Clinical Trial DHP2306R1 and DHP2306R2 in Healthy Adult Volunteers

Start: Oct 2023Est. completion: Dec 202354 patients
Phase 1Completed
NCT00823147Oregon TherapeuticsPain Catastrophizing Induction

Pain Catastrophizing as a Cause for Systemic Inflammation

Start: Jan 2009Est. completion: Sep 201493 patients
Phase 1Completed
NCT07218757Angeles TherapeuticsEmotional Awareness and Expression Therapy

Phase 1 Pilot of a Pragmatic Trial of EAET for Veterans With Chronic Pain

Start: Jan 2026Est. completion: Jul 202784 patients
N/ARecruiting
NCT05530902Applied MedicalMultidisciplinary Primary Rehabilitation Care

Multidisciplinary Primary Rehabilitation Care for Patients With Chronic Musculoskeletal Pain

Start: Feb 2022Est. completion: Feb 20261,400 patients
N/AUnknown

Signal Relief Patch in Musculoskeletal Pain

Start: Jan 2022Est. completion: Sep 202244 patients
N/ACompleted
NCT04552860Angeles TherapeuticsEmotional Awareness and Expression Therapy

vEAET for Older Veterans With Chronic Musculoskeletal Pain Pilot

Start: Aug 2020Est. completion: Aug 202116 patients
N/ACompleted

Impacts of Physiotherapy Services in a Quebec Emergency Department

Start: Sep 2018Est. completion: Jun 201978 patients
N/ACompleted
NCT03844880Angeles TherapeuticsEmotional Awareness and Expression Therapy

Emotional Awareness and Expression Therapy (EAET) or Cognitive Behavior Therapy (CBT) for Older Veterans With Chronic Musculoskeletal Pain

Start: Oct 2017Est. completion: Aug 201964 patients
N/ACompleted
NCT04457466LundbeckNerve Growth Factor

Assessment of the Effects of Extensive Somatosensory Training on Pain Processing

Start: Oct 2017Est. completion: Jul 2020100 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,182 patients
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.