Muscle Spasticity

4
Pipeline Programs
4
Companies
6
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
0
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Ipsen
DYSPORTApproved
botulinum toxin type a
Ipsen
Acetylcholine Release Inhibitor [EPC]injection2009

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Ipsen
IpsenChina - Tianjin
1 program
1
Botulinum toxin type APhase 41 trial
Active Trials
NCT00234546Completed162Est. Oct 2007
Teva
TevaIsrael - Petach Tikva
1 program
1
TizanidinePhase 1/22 trials
Active Trials
NCT00358293Completed20Est. Feb 2007
NCT00287157Completed5Est. May 2007
Motric Bio
Motric BioCA - Oakland
1 program
1
MTR-601Phase 11 trial
Active Trials
NCT06117020CompletedEst. Oct 2024
PathMaker Neurosystems
2 programs
MyoRegulator®N/A1 trial
MyoRegulator® deviceN/A1 trial
Active Trials
NCT04780191CompletedEst. Jan 2021
NCT04742257TerminatedEst. Jun 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
IpsenBotulinum toxin type A
TevaTizanidine
Motric BioMTR-601
TevaTizanidine
PathMaker NeurosystemsMyoRegulator® device
PathMaker NeurosystemsMyoRegulator®

Clinical Trials (6)

Total enrollment: 187 patients across 6 trials

NCT00234546IpsenBotulinum toxin type A

Asian Botulinum Clinical Trial Designed for Early Stroke Spasticity

Start: Feb 2003Est. completion: Oct 2007162 patients
Phase 4Completed
NCT00358293TevaTizanidine

Study of Nighttime Dosing of Sublingual Tizanidine (12 mg) in Multiple Sclerosis (MS) Patients With Significant Spasticity

Start: Dec 2006Est. completion: Feb 200720 patients
Phase 1/2Completed

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Start: Sep 2023Est. completion: Oct 2024
Phase 1Completed
NCT00287157TevaTizanidine

Pilot, Proof-of-Concept Study of Sublingual Tizanidine in Children With Chronic Traumatic Brain Injury (TBI)

Start: Dec 2006Est. completion: May 20075 patients
Phase 1Completed

Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity

Start: Mar 2022Est. completion: Jun 2024
N/ATerminated

Investigation of Treatment Using the MyoRegulator® Device in Patients With Spasticity in the Lower Limb Due to Stroke

Start: Jul 2018Est. completion: Jan 2021
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space