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Mucopolysaccharidosis Type I

1
Pipeline Programs
3
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 3 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Innovation Pharmaceuticals
1 program
1
AdalimumabPhase 1/2Monoclonal Antibody1 trial
Active Trials
NCT02437253Completed2Est. Jul 2016
Rare Disease Therapeutics
2 programs
Longitudinal Studies of Brain Structure and Function in MPS DisordersN/A1 trial
MRS to Determine Neuroinflammation and Oxidative Stress in MPS IN/A1 trial
Active Trials
NCT01870375Completed100Est. Aug 2019
NCT03576729Completed30Est. Aug 2019
CENTOGENE
CENTOGENEGermany - Rostock
1 program
Biomarker for Hurler Disease (BioHurler)N/A1 trial
Active Trials
NCT02298712Withdrawn0Est. Feb 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Innovation PharmaceuticalsAdalimumab
Rare Disease TherapeuticsMRS to Determine Neuroinflammation and Oxidative Stress in MPS I
CENTOGENEBiomarker for Hurler Disease (BioHurler)
Rare Disease TherapeuticsLongitudinal Studies of Brain Structure and Function in MPS Disorders

Clinical Trials (4)

Total enrollment: 132 patients across 4 trials

Effects of Adalimumab in Mucopolysaccharidosis Types I, II and VI

Start: May 2015Est. completion: Jul 20162 patients
Phase 1/2Completed
NCT03576729Rare Disease TherapeuticsMRS to Determine Neuroinflammation and Oxidative Stress in MPS I

MRS to Determine Neuroinflammation and Oxidative Stress in MPS I

Start: Nov 2018Est. completion: Aug 201930 patients
N/ACompleted
NCT02298712CENTOGENEBiomarker for Hurler Disease (BioHurler)

Biomarker for Hurler Disease (BioHurler)

Start: Aug 2018Est. completion: Feb 20210
N/AWithdrawn
NCT01870375Rare Disease TherapeuticsLongitudinal Studies of Brain Structure and Function in MPS Disorders

Longitudinal Studies of Brain Structure and Function in MPS Disorders

Start: Sep 2009Est. completion: Aug 2019100 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.