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Mucopolysaccharidosis I

5
Pipeline Programs
5
Companies
13
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
3
0
1
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Innovation Pharmaceuticals
3 programs
1
1
SomatropinPhase 2/31 trial
Adalimumab Injection [Humira]Phase 1/21 trial
Intrathecal recombinant human alpha iduronidaseN/A
Active Trials
NCT03153319Active Not Recruiting14Est. Feb 2027
NCT00748969Terminated2Est. Sep 2013
JCR Pharmaceuticals
JCR PharmaceuticalsJapan - Hyogo
2 programs
2
JR-171Phase 1/21 trial
JR-171Phase 1/21 trial
Active Trials
NCT04453085Completed14Est. May 2025
NCT04227600Completed18Est. Aug 2022
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
1
laronidasePhase 11 trial
Intrathecal recombinant human alpha iduronidaseN/A1 trial
Active Trials
NCT02232477Terminated6Est. Feb 2020
NCT00215527Terminated4Est. Oct 2011
Sanofi
SanofiPARIS, France
1 program
AldurazymePHASE_25 trials
Active Trials
NCT05134571Completed12Est. Jul 2023
NCT00418821Terminated2Est. Dec 2022
NCT00741338Completed7Est. Sep 2012
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
SanofiAldurazyme
SanofiAldurazyme
SanofiAldurazyme
SanofiAldurazyme
SanofiAldurazyme
Innovation PharmaceuticalsSomatropin
SanofiAldurazyme
JCR PharmaceuticalsJR-171
JCR PharmaceuticalsJR-171
Innovation PharmaceuticalsAdalimumab Injection [Humira]
SanofiAldurazyme
Angeles Therapeuticslaronidase
Angeles TherapeuticsIntrathecal recombinant human alpha iduronidase

Clinical Trials (13)

Total enrollment: 161 patients across 13 trials

China Post-marketing Surveillance (PMS) Study of Aldurazyme®

Start: Oct 2021Est. completion: Jul 202312 patients
Phase 4Completed

A Study of the Effect of Aldurazyme® (Laronidase) Treatment on Lactation in Female Patients With Mucopolysaccharidosis I (MPS I) and Their Breastfed Infants

Start: Oct 2010Est. completion: Dec 20222 patients
Phase 4Terminated

A Dose-optimization Study of Aldurazyme® (Laronidase) in Patients With Mucopolysaccharidosis I (MPS I) Disease

Start: Dec 2004Est. completion: Jan 200634 patients
Phase 4Completed

A Study Investigating the Relationship Between the Development of Laronidase Antibody and Urinary GAG (Glycosaminoglycan) Levels in Aldurazyme® Treated Patients

Start: Jul 2004Est. completion: May 200725 patients
Phase 4Completed

Study of Aldurazyme® Replacement Therapy in Patients With Mucopolysaccharidosis I (MPS I) Disease

Start: Dec 2005Est. completion: Oct 20063 patients
Phase 3Completed

Clinical Trial of Growth Hormone in MPS I, II, and VI

Start: Nov 2008Est. completion: Sep 20132 patients
Phase 2/3Terminated

A Study Evaluating the Safety and Pharmacokinetics of Aldurazyme® (Laronidase) in MPS I Patients Less Than 5 Years Old

Start: Oct 2002Est. completion: May 200520 patients
Phase 2Completed

An Extension Study of JR-171-101 Study in Patients With Mucopolysaccharidosis Type I (MPS I)

Start: Oct 2021Est. completion: May 202514 patients
Phase 1/2Completed

A Study of JR-171 in Patients With Mucopolysaccharidosis I

Start: Sep 2020Est. completion: Aug 202218 patients
Phase 1/2Completed
NCT03153319Innovation PharmaceuticalsAdalimumab Injection [Humira]

Study to Evaluate the Safety and Efficacy of Adalimumab in MPS I, II, and VI

Start: Jun 2017Est. completion: Feb 202714 patients
Phase 1/2Active Not Recruiting

Immune Tolerance Study With Aldurazyme® (Laronidase)

Start: Sep 2008Est. completion: Sep 20127 patients
Phase 1/2Completed

Intrathecal Enzyme Replacement Therapy for Spinal Cord Compression in Mucopolysaccharidosis (MPS) I

Start: Nov 2005Est. completion: Oct 20114 patients
Phase 1Terminated
NCT02232477Angeles TherapeuticsIntrathecal recombinant human alpha iduronidase

Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in MPS I

Start: Aug 2014Est. completion: Feb 20206 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.