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Mitral Valve Regurgitation (Degenerative or Functional)

0
Pipeline Programs
3
Companies
7
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Edwards Lifesciences
5 programs
Edwards EVOQUE Eos Mitral Valve Replacement SystemN/A1 trial
INNOVALVE systemN/A1 trial
Innovalve MR systemN/A1 trial
Innovalve MR systemN/A1 trial
Innovalve TMVR systemN/A1 trial
Active Trials
NCT02718001Active Not Recruiting123Est. Apr 2033
NCT04919980Recruiting65Est. Jul 2031
NCT05682066Completed11Est. Jan 2025
+2 more trials
Biocorp
BiocorpFrance - Issoire
1 program
Innovalve TMVR systemN/A1 trial
Active Trials
NCT05263375Withdrawn0Est. Jun 2025
HVR Cardio
HVR CardioFinland - Espoo
1 program
Transcatheter Mitral Valve RepairN/A1 trial
Active Trials
NCT07188233Recruiting5Est. Jul 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
HVR CardioTranscatheter Mitral Valve Repair
BiocorpInnovalve TMVR system
Edwards LifesciencesInnovalve TMVR system
Edwards LifesciencesINNOVALVE system
Edwards LifesciencesInnovalve MR system
Edwards LifesciencesInnovalve MR system
Edwards LifesciencesEdwards EVOQUE Eos Mitral Valve Replacement System

Clinical Trials (7)

Total enrollment: 209 patients across 7 trials

NCT07188233HVR CardioTranscatheter Mitral Valve Repair

Mitral Annular Repair With the CathHELIX™ Transcatheter System in Subjects With FMR

Start: Nov 2024Est. completion: Jul 20265 patients
N/ARecruiting
NCT05263375BiocorpInnovalve TMVR system

TVMR With the Innovalve System Trial - TWIST-BE TWIST-PILOT-BE

Start: Jun 2023Est. completion: Jun 20250
N/AWithdrawn
NCT05010746Edwards LifesciencesInnovalve TMVR system

TVMR With the Innovalve System Trial - Pilot Study in Italy

Start: Jan 2023Est. completion: Oct 20294 patients
N/AActive Not Recruiting
NCT04919980Edwards LifesciencesINNOVALVE system

TVMR With the INNOVALVE System Trial - Early Feasibility Study

Start: Sep 2022Est. completion: Jul 203165 patients
N/ARecruiting
NCT05682066Edwards LifesciencesInnovalve MR system

TVMR With the Innovalve System Trial - Pilot in Georgia

Start: Dec 2021Est. completion: Jan 202511 patients
N/ACompleted
NCT05688514Edwards LifesciencesInnovalve MR system

TVMR With the Innovalve System Trial - First In Human Israel

Start: Oct 2021Est. completion: Apr 20251 patients
N/ACompleted
NCT02718001Edwards LifesciencesEdwards EVOQUE Eos Mitral Valve Replacement System

Edwards EVOQUE Eos MISCEND Study

Start: Feb 2015Est. completion: Apr 2033123 patients
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 209 patients
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.