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Mitral Valve Disease

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Pipeline Programs
7
Companies
8
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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0
0
0
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Foldax
FoldaxUT - Salt Lake City
2 programs
Foldax TRIA Mitral ValveN/A1 trial
Mitral Valve ReplacementN/A1 trial
Active Trials
NCT04717570Unknown15Est. Dec 2025
NCT06191718Unknown70Est. Dec 2024
Eppendorf
EppendorfGermany - Hamburg
1 program
Hamburg TranscathEteR Mitral Valve REplacement RegiStryN/A1 trial
Active Trials
NCT04914468Recruiting300Est. Dec 2030
LivaNova
LivaNovaUK - London
1 program
MEMO 3D ringN/A1 trial
Active Trials
NCT01987635Completed33Est. Sep 2018
Corcym
CorcymUK - London
1 program
Mitral Valve ReplacementN/A1 trial
Active Trials
NCT05898230Unknown400Est. Dec 2024
Abbott
AbbottABBOTT PARK, IL
1 program
Mitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart ValveN/A1 trial
Active Trials
NCT02097420Completed23Est. Jul 2023
Medtronic
MedtronicNJ - Phillipsburg
1 program
Profile 3D™ and CG Future® annuloplasty systemN/A1 trial
Active Trials
NCT03283722Completed200Est. Feb 2021
Polares Medical
Polares MedicalCA - Palo Alto
1 program
Transcatheter mitral valve repairN/A1 trial
Active Trials
NCT06113354Not Yet Recruiting10Est. Dec 2029

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Polares MedicalTranscatheter mitral valve repair
CorcymMitral Valve Replacement
FoldaxMitral Valve Replacement
EppendorfHamburg TranscathEteR Mitral Valve REplacement RegiStry
FoldaxFoldax TRIA Mitral Valve
MedtronicProfile 3D™ and CG Future® annuloplasty system
AbbottMitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
LivaNovaMEMO 3D ring

Clinical Trials (8)

Total enrollment: 1,051 patients across 8 trials

NCT06113354Polares MedicalTranscatheter mitral valve repair

EXPLORE MRace: Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant

Start: Dec 2023Est. completion: Dec 202910 patients
N/ANot Yet Recruiting
NCT05898230CorcymMitral Valve Replacement

Retrospective Clinical Data Collection on Carbomedics OptiForm Mitral Heart Valve

Start: Nov 2023Est. completion: Dec 2024400 patients
N/AUnknown
NCT06191718FoldaxMitral Valve Replacement

Clinical Investigation for the Foldax Tria Mitral Valve- India

Start: Mar 2023Est. completion: Dec 202470 patients
N/AUnknown
NCT04914468EppendorfHamburg TranscathEteR Mitral Valve REplacement RegiStry

Hamburg TranscathEteR Mitral Valve REplacement RegiStry

Start: Mar 2021Est. completion: Dec 2030300 patients
N/ARecruiting
NCT04717570FoldaxFoldax TRIA Mitral Valve

Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement

Start: Feb 2021Est. completion: Dec 202515 patients
N/AUnknown
NCT03283722MedtronicProfile 3D™ and CG Future® annuloplasty system

PRESERVE-MITRAL Post-Market Registry

Start: Apr 2017Est. completion: Feb 2021200 patients
N/ACompleted
NCT02097420AbbottMitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve

HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve

Start: May 2015Est. completion: Jul 202323 patients
N/ACompleted
NCT01987635LivaNovaMEMO 3D ring

Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring

Start: Jan 2014Est. completion: Sep 201833 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 1,051 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.