Mid Face Volume Deficit

Pipeline Programs

Companies

Clinical Trials

1 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AbbVieNORTH CHICAGO, IL

3 programs

JUVÉDERMPhase 45 trials

HArmonyCa Lidocaine Injectable GelPhase 31 trial

Active Trials

NCT07032597Active Not Recruiting252Est. Oct 2026

NCT05452070Completed171Est. May 2025

NCT07186595Active Not Recruiting75Est. Aug 2026

+4 more trials

JETEMAKorea - Gangwon

1 program

JTM102N/A1 trial

Active Trials

NCT07265778Active Not Recruiting149Est. Dec 2026

Croma-PharmaAustria - Leobendorf

1 program

Thioderm StrongN/A1 trial

Active Trials

NCT06128109Completed20Est. Jan 2024

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

AbbVieJUVÉDERM

AbbVieHArmonyCa Lidocaine Injectable Gel

AbbVieJUVÉDERM

AbbVieHArmonyCa Lidocaine Injectable Gel

AbbVieJUVÉDERM

Showing 15 of 38 trials with date data

Clinical Trials (38)

Total enrollment: 5,074 patients across 38 trials

NCT07186595 AbbVieJUVÉDERM

A Study to Evaluate the Safety and Effectiveness of JUVÉDERM Products in Adult Participants for the Change of Their Overall Facial Appearance

Start: Sep 2025Est. completion: Aug 202675 patients

Phase 4Active Not Recruiting

NCT05077488 AbbVieJUVÉDERM

VFORM: Prospective, Open Label, Study to Evaluate VOLIFT With Lidocaine Treatment for FORehead Contouring and Marionette Lines

Start: Sep 2021Est. completion: Nov 2022163 patients

Phase 4Completed

NCT04390581 AbbVieJUVÉDERM

A Study to Evaluate the Effect of Juvederm Volift With Lidocaine on Aging Hands in Participants Age 35 and Older

Start: May 2020Est. completion: Dec 202275 patients

Phase 4Completed

NCT03796728 AbbVieJUVÉDERM

A Study to Evaluate the Effectiveness of Juvéderm® VOLIFT™ With Lidocaine for Lip Augmentation

Start: Dec 2018Est. completion: Jun 202060 patients

Phase 4Completed

NCT03425253 AbbVieJUVÉDERM

Sequential Treatment With BELKYRA® Then Juvéderm® VOLUMA™ With Lidocaine for Overall Improvement in Jawline Contour

Start: Feb 2018Est. completion: Dec 201958 patients

Phase 4Completed

NCT02980783 AbbVieJUVÉDERM

A Study to Evaluate the Effectiveness of Juvéderm® VOLIFT®™ With Lidocaine for Dynamic Radial Cheek Line Skin Depressions

Start: Oct 2016Est. completion: Dec 201653 patients

Phase 4Completed

NCT07032597 AbbVieHArmonyCa Lidocaine Injectable Gel

A Study to Assess Safety and Effectiveness of HArmonyCa Lidocaine Injectable Gel for Restoration and/or Creation of Mid-Face Volume in Adult Participants

Start: May 2025Est. completion: Oct 2026252 patients

Phase 3Active Not Recruiting

NCT06734351 AbbVieJUVÉDERM

A Study to Evaluate Safety and Effectiveness of NOA VOLUME Injectable Gel in Adult Participants Compared to JUVÉDERM VOLUMA XC for Improvement of Mid-Face Volume

Start: Dec 2024Est. completion: Jul 2029231 patients

Phase 3Recruiting

NCT05741034 AbbVieJUVÉDERM

A Study to Assess Adverse Events and Effectiveness of Injected JUVÉDERM® VOLITE™ Gel Filler for Change in Neck Lines in Adult Chinese Participants

Start: Apr 2023Est. completion: Dec 2024159 patients

Phase 3Completed

NCT05454033 AbbVieJUVÉDERM

A Study to Assess Adverse Events and Effectiveness of Intradermally Injected JUVÉDERM® VOLITE™ Gel Filler in Adult Participants in China With Fine Lines Around the Mouth

Start: Sep 2022Est. completion: Sep 2024198 patients

Phase 3Completed

NCT05452070 AbbVieHArmonyCa Lidocaine Injectable Gel

A Study to Assess Adverse Events and Change in Disease Activity of HArmonyCa Lidocaine Injectable Gel for Mid Face Soft Tissue Augmentation in Adult Participants

Start: Sep 2022Est. completion: May 2025171 patients

Phase 3Completed

NCT05316233 AbbVieJUVÉDERM

A Study to Assess Adverse Events and Change in Disease Activity of JUVÉDERM® VOLITE™ XC Injectable Gel for Change in Neck Appearance in Adult Participants

Start: May 2022Est. completion: Sep 2024159 patients

Phase 3Completed

NCT04891419 AbbVieJUVÉDERM

JUVÉDERM® VOLUMA® With Lidocaine for Correction of Temple Hollowing in Chinese Population

Start: Jul 2021Est. completion: Nov 2023168 patients

Phase 3Completed

NCT04559984 AbbVieJUVÉDERM

JUVÉDERM VOLUX® for Chin Retrusion in China

Start: Oct 2020Est. completion: Aug 2022150 patients

Phase 3Completed

NCT04414397 AbbVieJUVÉDERM

A Study Evaluating JUVÉDERM® VOLUMA® XC Injectable Gel for Correction of Temple Hollowing in Adult Participants ≥ 22 Years Old

Start: May 2020Est. completion: Oct 2022205 patients

Phase 3Completed

NCT03712137 AbbVieJUVÉDERM

Study of the Safety and Effectiveness of JUVÉDERM VOLUX™ XC Injectable Gel for Restoring Jawline Definition

Start: Nov 2018Est. completion: Jan 2021206 patients

Phase 3Completed

NCT03418545 AbbVieJUVÉDERM

A Safety and Effectiveness of VOLBELLA XC Hyaluronic Acid (HA) Injectable Gel to Correct Infraorbital Hollowing

Start: Jan 2018Est. completion: Aug 2019163 patients

Phase 3Completed

NCT06547125 AbbVieJUVÉDERM

A Study to Assess Adverse Events and Effectiveness of Intradermally Injected JUVÉDERM® VOLITE™ Gel Filler in Adult Participants For the Improvement of Skin Quality

Start: Jul 2024Est. completion: Feb 2026135 patients

Phase 2/3Completed

NCT07265778 JETEMAJTM102

Clinical Investigation for Evaluating the Safety and Efficacy of JTM102 to Mid Face Volume Deficiency

Start: Oct 2024Est. completion: Dec 2026149 patients

N/AActive Not Recruiting

NCT06128109 Croma-PharmaThioderm Strong

THIODERM STRONG Compared to Juvéderm® VOLUMA® Lidocaine for the Treatment of Midface Volume Deficit

Start: Jan 2023Est. completion: Jan 202420 patients

N/ACompleted

NCT04687046 AbbVieJUVÉDERM

A Study of JUVÉDERM VOLUX® Injectable Gel for Chin Enhancement in Chinese Adults Using Real-World Evidence

Start: Feb 2021Est. completion: Feb 202290 patients

N/ACompleted

NCT04389866 AbbVieJUVÉDERM

Jowl Improvement With Injectable Fillers

Start: Sep 2020Est. completion: Oct 202216 patients

N/ACompleted

NCT03728309 AbbVieJUVÉDERM

JUVÉDERM® VOLITE™ XC for Cheek Skin Smoothness

Start: Nov 2018Est. completion: Jul 2020209 patients

N/ACompleted

NCT03438266 AbbVieJUVÉDERM

A Study of the Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Cheek Augmentation Using Cannula

Start: Feb 2018Est. completion: Aug 201866 patients

N/ACompleted

NCT03430986 AbbVieJUVÉDERM

Safety and Effectiveness of JUVÉDERM® VOLUMA® With Lidocaine for Improvement of Volume and Aesthetic Appearance of the Nose in Chinese Adults

Start: Feb 2018Est. completion: Dec 2019164 patients

N/ACompleted

NCT03166618 AbbVieJUVÉDERM

Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Correction of Temple Hollowing

Start: Apr 2017Est. completion: Jul 20171 patients

N/ATerminated

NCT02833077 AbbVieJUVÉDERM

A Safety and Effectiveness Study of JUVÉDERM VOLUMA® XC Injectable Gel for Chin Augmentation

Start: Jun 2016Est. completion: Oct 2018221 patients

N/ACompleted

NCT03519204 AbbVieJUVÉDERM

Safety and Effectiveness of JUVÉDERM® VOLBELLA® With Lidocaine for Lip Enhancement in Chinese Adults

Start: Jan 2016Est. completion: Mar 2018176 patients

N/ACompleted

NCT02558283 AbbVieJUVÉDERM

A Safety and Efficacy Study of JUVÉDERM® VOLIFT® With Lidocaine and Restylane® for Nasolabial Folds in Chinese Adults

Start: Jan 2016Est. completion: Jun 2017175 patients

N/ACompleted

NCT01998581 AbbVieJUVÉDERM

A Safety and Effectiveness Study of JUVÉDERM VOLBELLA® XC Injectable Gel for Lip and Perioral Enhancement

Start: Nov 2013Est. completion: May 2015225 patients

N/ACompleted

NCT01976663 AbbVieJUVÉDERM

A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds

Start: Oct 2013Est. completion: Oct 2015126 patients

N/ACompleted

NCT01846039 AbbVieJUVÉDERM

JUVÉDERM VOLUMA® to Enhance the Appearance of the Asian Nose

Start: Apr 2013Est. completion: Aug 201429 patients

N/ACompleted

NCT01629134 AbbVieJUVÉDERM

Postmarket Study of JUVÉDERM VOLBELLA™ With Lidocaine in the Lips

Start: Jun 2012Est. completion: Dec 201262 patients

N/ACompleted

NCT01680497 AbbVieJUVÉDERM

Post-Market Study of JUVÉDERM VOLIFT™ With Lidocaine for the Correction of Nasolabial Folds

Start: Jun 2012Est. completion: Mar 201470 patients

N/ACompleted

NCT01559064 AbbVieJUVÉDERM

The Volumizing Effect of Juvéderm VOLUMA® in the Mid-Face

Start: Feb 2012Est. completion: Aug 2012115 patients

N/ACompleted

NCT01176773 AbbVieJUVÉDERM

Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement

Start: Aug 2010Est. completion: Jan 201262 patients

N/ACompleted

NCT00978042 AbbVieJUVÉDERM

Safety and Effectiveness of Juvéderm® VOLUMA XC Injectable Gel for Cheek Augmentation

Start: Aug 2009Est. completion: Apr 2014345 patients

N/ACompleted

NCT00653861 AbbVieJUVÉDERM

Safety and Effectiveness of JUVÉDERM™ Injectable Gel With Lidocaine

Start: Apr 2008Est. completion: Jul 200872 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals

1 actively recruiting trials targeting 5,074 patients

3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.