Metabolism and Nutrition Disorder

37
Pipeline Programs
1
Companies
35
Clinical Trials
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
20
0
2
0
10
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
18100%
+ 17 programs with unclassified modality

On Market (5)

Approved therapies currently available

Novo Nordisk
OZEMPICApproved
semaglutide
Novo Nordisk
GLP-1 Receptor Agonist [EPC]subcutaneous2017
Novo Nordisk
RYBELSUSApproved
semaglutide
Novo Nordisk
oral2020
Novo Nordisk
SAXENDAApproved
liraglutide
Novo Nordisk
GLP-1 Receptor Agonist [EPC]subcutaneous2014
Novo Nordisk
VICTOZAApproved
liraglutide
Novo Nordisk
GLP-1 Receptor Agonist [EPC]subcutaneous2010
Novo Nordisk
WEGOVYApproved
semaglutide
Novo Nordisk
GLP-1 Receptor Agonist [EPC]subcutaneous2021

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
35 programs
20
2
10
1
LiraglutidePhase 3Peptide1 trial
Liraglutide 3.0 mgPhase 3Peptide1 trial
SemaglutidePhase 3Peptide1 trial
SemaglutidePhase 3Peptide1 trial
liraglutidePhase 3Peptide1 trial
+30 more programs
Active Trials
NCT03235102Completed2,545Est. Oct 2017
NCT03223493Completed3,767Est. Nov 2015
NCT02967757Completed316Est. May 2019
+32 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Novo NordiskSemaglutide
Novo NordiskSemaglutide
Novo NordiskLiraglutide 3.0 mg
Novo Nordiskliraglutide
Novo NordiskLiraglutide
Novo Nordiskliraglutide
Novo Nordiskliraglutide
Novo Nordiskliraglutide
Novo Nordiskliraglutide
Novo Nordiskliraglutide
Novo Nordisksemaglutide
Novo Nordiskliraglutide
Novo NordiskNNC9204-1706
Novo NordiskNNC0194-0499
Novo NordiskNNC9204-1177 A 1.0 mg/mL

Showing 15 of 35 trials with date data

Clinical Trials (35)

Total enrollment: 18,739 patients across 35 trials

Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

Start: Jun 2018Est. completion: Mar 2020902 patients
Phase 3Completed

STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

Start: Jun 2018Est. completion: Mar 20211,961 patients
Phase 3Completed
NCT02963922Novo NordiskLiraglutide 3.0 mg

Effect and Safety of Liraglutide 3.0 mg in Subjects With Overweight or Obesity and Type 2 Diabetes Mellitus Treated With Basal Insulin

Start: Feb 2017Est. completion: Sep 2018396 patients
Phase 3Completed

Effect and Safety of Liraglutide 3.0 mg as an Adjunct to Intensive Behaviour Therapy for Obesity in a Non-specialist Setting

Start: Feb 2017Est. completion: Jun 2018282 patients
Phase 3Completed

Effect of Liraglutide for Weight Management in Pubertal Adolescent Subjects With Obesity

Start: Sep 2016Est. completion: Aug 2019251 patients
Phase 3Completed

Effect of Liraglutide for Weight Management in Paediatric Subjects With Prader-Willi Syndrome

Start: Nov 2015Est. completion: Nov 202056 patients
Phase 3Completed

Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea

Start: Jun 2012Est. completion: Jun 2013359 patients
Phase 3Completed

Effect of Liraglutide on Body Weight in Overweight or Obese Subjects With Type 2 Diabetes: SCALE™ - Diabetes

Start: Jun 2011Est. completion: Jan 2013846 patients
Phase 3Completed

Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetes

Start: Jun 2011Est. completion: Mar 20153,731 patients
Phase 3Completed

Comparison of Liraglutide Versus Placebo in Weight Loss Maintenance in Obese Subjects: SCALE - Maintenance

Start: Oct 2008Est. completion: Sep 2010422 patients
Phase 3Completed

Investigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes Mellitus

Start: Oct 2015Est. completion: Apr 2017957 patients
Phase 2Completed

The Effect of Liraglutide on Body Weight in Obese Subjects Without Diabetes

Start: Jan 2007Est. completion: Apr 2009564 patients
Phase 2Completed

Research Study of a New Medicine (NNC9204-1706) in People With Overweight or Obesity

Start: Sep 2018Est. completion: Oct 201960 patients
Phase 1Completed

A Research Study Looking at a New Study Medicine (NNC0194-0499) for Weight Control in People With Overweight or Obesity

Start: Mar 2018Est. completion: Jun 201957 patients
Phase 1Completed
NCT03308721Novo NordiskNNC9204-1177 A 1.0 mg/mL

Research Study Investigating Study Medicine (NNC9204-1177) for Weight Management in People With Overweight or Obesity

Start: Oct 2017Est. completion: Jan 202099 patients
Phase 1Completed

Investigation of Single Ascending Doses of NNC9204-1706 in Male Subjects Being Overweight or With Obesity

Start: Mar 2017Est. completion: Aug 201734 patients
Phase 1Completed

First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of NNC0194-0499 in Male Subjects With Overweight or Obesity

Start: Jan 2017Est. completion: Oct 201756 patients
Phase 1Completed

Investigation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Dosing of NNC0174-0833 in Subjects With Obesity or Overweight

Start: Nov 2016Est. completion: Jan 201896 patients
Phase 1Completed

A First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics for Single Doses of NNC9204-1177 in Subjects Being Overweight or With Obesity.

Start: Oct 2016Est. completion: Sep 201749 patients
Phase 1Completed

Investigating Safety, Tolerability, PK and PD for Multiple Doses of NNC9204-0530 in Combination With Liraglutide in Male and Female Subjects Being Overweight or With Obesity

Start: Aug 2016Est. completion: Sep 2017187 patients
Phase 1Completed

A Trial Investigating Safety, Tolerability, PK and PD for Multiple Doses of NNC9204-0530 in Male and Female Subjects Being Overweight or With Obesity

Start: Jul 2016Est. completion: Jul 201748 patients
Phase 1Completed

A Trial to Assess the Effects of Liraglutide on Gallbladder Emptying in Overweight and Obese Subjects.

Start: Mar 2016Est. completion: Feb 201752 patients
Phase 1Completed

A Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Liraglutide in Obese Children Aged 7 to 11 Years

Start: Mar 2016Est. completion: Apr 201724 patients
Phase 1Completed

A First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics for Single Doses and Multiple Doses of NNC0165-1562 in Overweight to Obese But Otherwise Healthy Subjects

Start: Oct 2015Est. completion: Feb 201793 patients
Phase 1Completed

Investigation on Safety, Tolerability and Pharmacokinetics of Single Doses of NNC0174-0833 in Normal Weight, Overweight to Obese But Otherwise Healthy Male Subjects

Start: Dec 2014Est. completion: Mar 201654 patients
Phase 1Completed

Investigate Safety, Tolerability and Pharmacokinetics for Single Doses of NNC9204-0530 Alone and in Combination With Liraglutide in Overweight to Obese But Otherwise Healthy Male Subjects

Start: Sep 2014Est. completion: Jul 2016163 patients
Phase 1Completed

Investigating Bioequivalence Between Single-dose Liraglutide Administered Subcutaneously With Two Different Pen-injectors

Start: Aug 2014Est. completion: Sep 201424 patients
Phase 1Completed

A Randomised, Double-blind, Placebo-controlled Trial to Assess Safety, Tolerability and Pharmacokinetics of Liraglutide in Obese Adolescent Subjects Aged 12 to 17 Years

Start: Feb 2013Est. completion: May 201421 patients
Phase 1Completed
NCT01044108Novo NordiskNNC 0070-0002-0453

A Two Part Trial Investigating an Anti-obesity Drug in Overweight/Obese Male and Female Healthy Volunteers

Start: Jan 2010Est. completion: Sep 2011117 patients
Phase 1Terminated

A Trial to Assess the Effect of Liraglutide on Gastric Emptying in Healthy Obese Volunteers

Start: Sep 2009Est. completion: Jun 201149 patients
Phase 1Completed
NCT00728455Novo NordiskNNC 0070-0002-0349

Examination of the Safety and Tolerability of NNC 0070-0002-0349 in Overweight/Obese Volunteers

Start: Jul 2008Est. completion: Dec 20090
Phase 1Withdrawn
NCT00665665Novo NordiskNNC 0070-0002-0182

Safety, Efficacy, Tolerability and Pharmacokinetics of NNC 0070-0002-0182 in Overweight or Obese Male and Female Volunteers

Start: Nov 2007Est. completion: Oct 2008101 patients
Phase 1Terminated
NCT03235102Novo NordiskNo treatment given

Awareness, Care and Treatment in Obesity Management

Start: Aug 2017Est. completion: Oct 20172,545 patients
N/ACompleted

In-market Utilisation of Liraglutide Used for Weight Management in Europe

Start: Dec 2016Est. completion: May 2019316 patients
N/ACompleted
NCT03223493Novo NordiskNo treatment given

Awareness, Care & Treatment in Obesity Management (ACTION) Study

Start: Oct 2015Est. completion: Nov 20153,767 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 late-stage (Phase 3) programs — potential near-term approvals
Peptide is the dominant modality (100% of programs)
1 companies competing in this space