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Menorrhagia

8
Pipeline Programs
16
Companies
24
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
3
4
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
E2NomacPhase 4
MSD
MSDIreland - Ballydine
1 program
1
E2NomacPhase 41 trial
Active Trials
NCT01715025Unknown30Est. Aug 2015
CooperSurgical
CooperSurgicalCT - Trumbull
1 program
1
Extended treatment regimen using Her Option CryotherapyPhase 41 trial
Active Trials
NCT00094536Completed82Est. Jun 2009
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
TamoxifenPhase 41 trial
Active Trials
NCT02824224Completed42Est. Jan 2018
Bayer
BayerLEVERKUSEN, Germany
7 programs
1
1
Levonorgestrel IUSPhase 31 trial
AsoprisnilPhase 21 trial
Chronic hormonal treatmentN/A1 trial
LevonorgestrelN/A1 trial
LevonorgestrelN/A1 trial
+2 more programs
Active Trials
NCT03751800Completed422Est. May 2021
NCT00874653Completed78Est. Dec 2008
NCT00864136Completed647Est. Nov 2010
+4 more trials
JW Pharmaceutical
JW PharmaceuticalKorea - Seoul
1 program
1
KLH-2109+ Leurprorelin acetate PlaceboPhase 31 trial
Active Trials
NCT07378098Recruiting254Est. Sep 2028
Boston Scientific
Boston ScientificCA - Valencia
1 program
1
uterine artery embolizationPhase 31 trial
Active Trials
NCT00100191Completed120Est. Apr 2006
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
5 programs
Tranexamic acidPHASE_31 trial
Tranexamic acid tabletsPHASE_31 trial
Tranexamic acid tabletsPHASE_31 trial
Tranexamic acid tabletsPHASE_31 trial
tranexamic acidPHASE_41 trial
Active Trials
NCT01280981Completed288Est. May 2009
NCT00401193Completed304Est. May 2008
NCT00386308Completed196Est. May 2008
+2 more trials
Hologic
HologicMARLBOROUGH, MA
2 programs
NovaSureN/A1 trial
Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pillsPHASE_41 trial
Active Trials
NCT01124357Completed81Est. Oct 2008
NCT01165307Completed77Est. Oct 2015
Channel Therapeutics
Channel TherapeuticsNJ - North Brunswick
1 program
CereneN/A1 trial
Active Trials
NCT02842736Completed242Est. May 2020
Channel Medsystems
Channel MedsystemsCA - Berkeley
1 program
CereneN/A
Minerva Surgical
Minerva SurgicalCA - Santa Clara
1 program
Genesys HTAN/A1 trial
Active Trials
NCT01197547Completed1,014Est. Aug 2012
Gynesonics
GynesonicsCA - Redwood City
1 program
VizAblate SystemN/A1 trial
Active Trials
NCT01998854Terminated4Est. Jan 2015
LiNA MEDICAL
LiNA MEDICALDenmark - Naerum
1 program
LibrataPHASE_31 trial
Active Trials
NCT03725306Unknown200Est. Dec 2022
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
E2NomacPHASE_4
Teva
TevaIsrael - Petach Tikva
1 program
NaproxenPHASE_41 trial
Active Trials
NCT02519231Completed34Est. Nov 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Oregon TherapeuticsTamoxifen
TevaNaproxen
MSDE2Nomac
Ferring Pharmaceuticalstranexamic acid
HologicEstradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills
CooperSurgicalExtended treatment regimen using Her Option Cryotherapy
JW PharmaceuticalKLH-2109+ Leurprorelin acetate Placebo
LiNA MEDICALLibrata
Ferring PharmaceuticalsTranexamic acid
Ferring PharmaceuticalsTranexamic acid tablets
Ferring PharmaceuticalsTranexamic acid tablets
BayerLevonorgestrel IUS
Ferring PharmaceuticalsTranexamic acid tablets
Boston Scientificuterine artery embolization
BayerAsoprisnil

Showing 15 of 24 trials with date data

Clinical Trials (24)

Total enrollment: 9,112 patients across 24 trials

Tamoxifen to Reduce Unscheduled Bleeding in New Users of the Levonorgestrel-releasing Intrauterine System (LNG-IUS)

Start: Sep 2016Est. completion: Jan 201842 patients
Phase 4Completed

Copper IUD Treatment Observation Study

Start: Feb 2016Est. completion: Nov 201734 patients
Phase 4Completed

A New Treatment Option for Heavy Menstrual Bleeding

Start: Apr 2013Est. completion: Aug 201530 patients
Phase 4Unknown

Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding

Start: Aug 2010Est. completion: Apr 201120 patients
Phase 4Completed
NCT01165307HologicEstradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills

Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia

Start: Aug 2009Est. completion: Oct 201577 patients
Phase 4Completed
NCT00094536CooperSurgicalExtended treatment regimen using Her Option Cryotherapy

Evaluation of Modified Treatment Regimens for Treatment of Heavy Menstrual Bleeding Using the HerOption® System

Start: Apr 2004Est. completion: Jun 200982 patients
Phase 4Completed
NCT07378098JW PharmaceuticalKLH-2109+ Leurprorelin acetate Placebo

to Evaluate the Efficacy and Safety of KLH-2109 in Patients With Uterine Fibroids and Menorrhagia

Start: Feb 2026Est. completion: Sep 2028254 patients
Phase 3Recruiting

Librata Endometrial Ablation Device Treatment to Reduce Menstrual Blood Loss

Start: Jan 2019Est. completion: Dec 2022200 patients
Phase 3Unknown

A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding

Start: Apr 2007Est. completion: May 2009288 patients
Phase 3Completed
NCT00401193Ferring PharmaceuticalsTranexamic acid tablets

Efficacy and Safety of XP12B in Women With Menorrhagia

Start: Nov 2006Est. completion: May 2008304 patients
Phase 3Completed
NCT00386308Ferring PharmaceuticalsTranexamic acid tablets

Efficacy and Safety Study of XP12B in Women With Menorrhagia

Start: Oct 2006Est. completion: May 2008196 patients
Phase 3Completed
NCT00360490BayerLevonorgestrel IUS

Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS)

Start: Jul 2006Est. completion: Jun 2008165 patients
Phase 3Completed
NCT00113568Ferring PharmaceuticalsTranexamic acid tablets

Safety Study of XP12B in Women With Menorrhagia

Start: Jun 2005Est. completion: May 2009784 patients
Phase 3Completed
NCT00100191Boston Scientificuterine artery embolization

Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids

Start: Feb 2002Est. completion: Apr 2006120 patients
Phase 3Completed

Menorrhagia Study in Women With Treatment-resistant Menorrhagia

Start: Nov 2001Est. completion: Jan 200426 patients
Phase 2Completed
NCT03751800BayerChronic hormonal treatment

A Study Run at Multiple Study Sites to Test Whether the SAMANTA Questionnaire That is Used to Diagnose Heavy Menstrual Bleeding (HMB), Can Also be Used to Assess Changes of Severity of HMB in Women With HMB Who Are Treated During 12 Months With a Chronic Hormonal Treatment

Start: Dec 2018Est. completion: May 2021422 patients
N/ACompleted

A CLinical Study to Evaluate the Safety And Effectiveness of the CeRene DevIce to Treat HeavY Menstrual Bleeding

Start: Apr 2016Est. completion: May 2020242 patients
N/ACompleted
NCT02304510BayerPrevalence of Heavy Menstrual Bleeding in Female Population Living in Beijing

Prevalence of Heavy Menstrual Bleeding in Female Population Living in Beijing

Start: Nov 2014Est. completion: Dec 20162,455 patients
N/ACompleted
NCT01998854GynesonicsVizAblate System

Observational Prospective Study on Patients With Symptomatic Uterine Fibroids Treated With VizAblate® Intrauterine-ultrasound Guided RF Ablation

Start: Feb 2013Est. completion: Jan 20154 patients
N/ATerminated

A Swedish Questionnaire Study to Investigate the Perception of Menstrual Bleedings

Start: May 2012Est. completion: Jun 20121,547 patients
N/ACompleted

Registry Study of Genesys HTA for Treatment of Menorrhagia

Start: Nov 2010Est. completion: Aug 20121,014 patients
N/ACompleted
NCT00864136BayerLevonorgestrel

Mirena or Conventional Medical Treatment for Menorrhagia

Start: Nov 2008Est. completion: Nov 2010647 patients
N/ACompleted
NCT00874653BayerLevonorgestrel

Survey on Patient Satisfaction Rate for Mirena Use in Heavy Menstrual Bleeding

Start: Apr 2008Est. completion: Dec 200878 patients
N/ACompleted

A Study to Compare the Effectiveness of Two Different Outpatient Endometrial Ablation Techniques Used for Heavy Periods

Start: May 2006Est. completion: Oct 200881 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 9,112 patients
16 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.