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MDD

3
Pipeline Programs
6
Companies
6
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 5 programs with unclassified modality

On Market (1)

Approved therapies currently available

Otsuka
REXULTIApproved
brexpiprazole
Otsuka
Atypical Antipsychotic [EPC]oral2015
630M Part D

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Otsuka
OtsukaJapan - Tokushima
1 program
1
1
BrexpiprazolePhase 3Small Molecule1 trial
Active Trials
NCT02013609Completed48Est. Oct 2014
Lundbeck
LundbeckDenmark - Copenhagen
1 program
1
VortioxetinePhase 41 trial
Active Trials
NCT04220996Completed100Est. Mar 2021
Neurolief
NeuroliefIsrael - Netanya
1 program
Relivion®DP- ActiveN/A1 trial
Active Trials
NCT04279522Completed124Est. Jun 2024
Neuronetics
NeuroneticsMALVERN, PA
1 program
Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT06699940Completed7,690Est. May 2023
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT06572683Enrolling By Invitation84Est. Oct 2028
Vigonvita
VigonvitaChina - Suzhou
1 program
LV232 40mgPHASE_21 trial
Active Trials
NCT06828887Recruiting400Est. Dec 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
LundbeckVortioxetine
OtsukaBrexpiprazole
VigonvitaLV232 40mg
Angeles TherapeuticsTranscranial Magnetic Stimulation
NeuroneticsTranscranial Magnetic Stimulation
NeuroliefRelivion®DP- Active

Clinical Trials (6)

Total enrollment: 8,446 patients across 6 trials

Vortioxetine in Patients With Depression Coexisting With General Anxiety Disorder (GAD)

Start: Dec 2019Est. completion: Mar 2021100 patients
Phase 4Completed
NCT02013609OtsukaBrexpiprazole

Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment

Start: Nov 2013Est. completion: Oct 201448 patients
Phase 3Completed

Dose-Finding Clinical Trial to Evaluate the Efficacy and Safety of LV232 Capsules in the Treatment of MDD

Start: Apr 2025Est. completion: Dec 2026400 patients
Phase 2Recruiting
NCT06572683Angeles TherapeuticsTranscranial Magnetic Stimulation

Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder

Start: Feb 2024Est. completion: Oct 202884 patients
N/AEnrolling By Invitation
NCT06699940NeuroneticsTranscranial Magnetic Stimulation

A Retrospective Study to Evaluate NeuroStar® Advanced Therapy in Adolescents

Start: May 2023Est. completion: May 20237,690 patients
N/ACompleted
NCT04279522NeuroliefRelivion®DP- Active

The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)

Start: Aug 2021Est. completion: Jun 2024124 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 8,446 patients
6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.