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MASH

2
Pipeline Programs
8
Companies
5
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 7 programs with unclassified modality

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Opko Health
Opko HealthMIAMI, FL
1 program
1
OPK-88006Phase 1/21 trial
Active Trials
NCT07512427Recruiting30Est. Dec 2027
Genentech
GenentechCA - Oceanside
1 program
1
RO7790121Phase 11 trial
Active Trials
NCT06903065Active Not Recruiting56Est. Dec 2026
Innovation Pharmaceuticals
1 program
Global Research Initiative for Patients Screening on MASHN/A
Echosens
EchosensFrance - Paris
1 program
Global Research Initiative for Patients Screening on MASHN/A1 trial
Active Trials
NCT05651724Recruiting10,000Est. Mar 2031
Inventiva
InventivaDAIX, France
1 program
Global Research Initiative for Patients Screening on MASHN/A
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
Global Research Initiative for Patients Screening on MASHN/A
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
Global Research Initiative for Patients Screening on MASHN/A
Sagimet Biosciences
Sagimet BiosciencesCA - San Mateo
1 program
DenifanstatPHASE_3Small Molecule2 trials
Active Trials
NCT07863193Recruiting800Est. Apr 2028
NCT06594523Withdrawn0Est. Dec 2030

Trial Timeline

Clinical trial activity over time

2023
2024
2025
2026
2027
2028
2029
2030
2031
Sagimet BiosciencesDenifanstat
Sagimet BiosciencesDenifanstat
Opko HealthOPK-88006
GenentechRO7790121
EchosensGlobal Research Initiative for Patients Screening on MASH

Clinical Trials (5)

Total enrollment: 10,886 patients across 5 trials

Phase 3 Study of Denifanstat in Participants With Moderate to Severe Acne (AURORA)

Start: Oct 2026Est. completion: Apr 2028800 patients
Phase 3Recruiting

A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosis

Start: Mar 2025Est. completion: Dec 20300
Phase 3Withdrawn

Phase 1/2 Study of OPK-88006 in Healthy and Presumed MASH Participants

Start: Jul 2026Est. completion: Dec 202730 patients
Phase 1/2Recruiting

A Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Participants With Advanced MASH Liver Fibrosis

Start: Apr 2025Est. completion: Dec 202656 patients
Phase 1Active Not Recruiting
NCT05651724EchosensGlobal Research Initiative for Patients Screening on MASH

Global Research Initiative for Patients Screening on MASH

Start: Jun 2023Est. completion: Mar 203110,000 patients
N/ARecruiting

Related Jobs

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 10,886 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.