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Macrophage Activation Syndrome

0
Pipeline Programs
1
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2100%
+ 1 programs with unclassified modality

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Swedish Orphan Biovitrum
3 programs
Chart reviewN/A1 trial
EmapalumabPHASE_2Monoclonal Antibody2 trials
EmapalumabPHASE_3Monoclonal Antibody1 trial
Active Trials
NCT06405152Completed75Est. Sep 2024
NCT07486869Not Yet Recruiting5Est. May 2027
NCT03311854Completed14Est. May 2020
+1 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Swedish Orphan BiovitrumEmapalumab
Swedish Orphan BiovitrumEmapalumab
Swedish Orphan BiovitrumEmapalumab
Swedish Orphan BiovitrumChart review

Clinical Trials (4)

Total enrollment: 127 patients across 4 trials

Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE

Start: Dec 2021Est. completion: Jun 202533 patients
Phase 3Completed

Emapalumab MDA5 Rapidly Progressive Interstitial Lung Disease (RP-ILD) Study

Start: May 2026Est. completion: May 20275 patients
Phase 2Not Yet Recruiting

A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing Macrophage Activation Syndrome/Secondary HLH (MAS/sHLH)

Start: Feb 2018Est. completion: May 202014 patients
Phase 2Completed

Assessment of Macrophage Activation syndromE in STill's Disease

Start: Sep 2023Est. completion: Sep 202475 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

Monoclonal Antibody is the dominant modality (100% of programs)
1 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.