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Lysosomal Acid Lipase Deficiency

1
Pipeline Programs
1
Companies
9
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

AstraZeneca
KANUMAApproved
sebelipase alfa
AstraZeneca
Hydrolytic Lysosomal Cholesteryl Ester-specific Enzyme [EPC]injection2015

Competitive Landscape

1 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
1
Lysosomal Acid Lipase (LAL) Deficiency RegistryN/A1 trial
Lysosomal Acid Lipase Deficiency in Risk GroupsN/A1 trial
enzyme analysisN/A1 trial
KANUMA(sebelipase alfa)N/A5 trials
Active Trials
NCT01633489Recruiting300Est. Aug 2029
NCT07455864Recruiting1,200Est. Jun 2028
NCT01716728Unknown60
+5 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
AstraZenecasebelipase alfa
AstraZenecasebelipase alfa
AstraZenecasebelipase alfa
AstraZenecasebelipase alfa
AstraZenecasebelipase alfa
AstraZenecaLysosomal Acid Lipase Deficiency in Risk Groups
AstraZenecaLysosomal Acid Lipase (LAL) Deficiency Registry
AstraZenecaenzyme analysis

Clinical Trials (9)

Total enrollment: 1,627 patients across 9 trials

NCT01371825AstraZenecasebelipase alfa

Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency

Start: May 2011Est. completion: Jan 20189 patients
Phase 2/3Completed
NCT02112994AstraZenecasebelipase alfa

Safety and Efficacy Study of Sebelipase Alfa in Participants With Lysosomal Acid Lipase Deficiency

Start: Jun 2014Est. completion: Dec 201731 patients
Phase 2Completed
NCT02193867AstraZenecasebelipase alfa

Clinical Study In Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency

Start: Jun 2014Est. completion: Oct 201810 patients
Phase 2Terminated
NCT01488097AstraZenecasebelipase alfa

Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of SBC-102 (Sebelipase Alfa) in Adult Subjects With Lysosomal Acid Lipase Deficiency

Start: Dec 2011Est. completion: Jun 20178 patients
Phase 2Completed
NCT01307098AstraZenecasebelipase alfa

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Start: Apr 2011Est. completion: Jan 20129 patients
Phase 1/2Completed
NCT02376751AstraZenecasebelipase alfa

An Expanded Access Protocol for Sebelipase Alfa for Patients With Lysosomal Acid Lipase Deficiency

N/ANo Longer Available
NCT07455864AstraZenecaLysosomal Acid Lipase Deficiency in Risk Groups

Lysosomal Acid Lipase Deficiency in Risk Groups

Start: Feb 2026Est. completion: Jun 20281,200 patients
N/ARecruiting
NCT01633489AstraZenecaLysosomal Acid Lipase (LAL) Deficiency Registry

Lysosomal Acid Lipase (LAL) Deficiency Registry

Start: May 2013Est. completion: Aug 2029300 patients
N/ARecruiting
NCT01716728AstraZenecaenzyme analysis

Identification of Undiagnosed Lysosomal Acid Lipase Deficiency

Start: Aug 201260 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 1,627 patients
1 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.