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Lymphedema

2
Pipeline Programs
8
Companies
17
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Alliance Pharmaceuticals
2 programs
1
1
quality of life assessmentPhase 31 trial
GLP-1 receptor agonistPhase 11 trial
Active Trials
NCT07012642Recruiting110Est. Apr 2027
NCT00376597Completed568Est. Jun 2017
Koya Medical
Koya MedicalCA - Oakland
5 programs
Cross over DeviceN/A1 trial
Crossover DeviceN/A1 trial
Dayspring Active Wearable Compression SystemN/A1 trial
Dayspring Active Wearable Compression SystemN/A1 trial
Insight Pro Device for DiagnosisN/A1 trial
Active Trials
NCT05507346Completed121Est. Jan 2024
NCT04908254Completed50Est. Dec 2021
NCT04897035Completed24Est. Jul 2022
+2 more trials
Tactile Medical
Tactile MedicalMN - Minneapolis
4 programs
Advanced Pneumatic Compression DeviceN/A1 trial
Advanced Pneumatic Compression DeviceN/A1 trial
Conservative careN/A1 trial
Flexitouch SystemN/A1 trial
Active Trials
NCT04797390Completed236Est. Dec 2024
NCT02661646Terminated249Est. Feb 2023
NCT04116099Terminated63Est. Nov 2021
+1 more trials
ImpediMed
ImpediMedAustralia - Pinkenba
2 programs
23-32 mmHg compression sleeve with gauntletN/A1 trial
The Equivalency of the Imp SFB7+ (L-Dex U400) With the Imp XCA DeviceN/A1 trial
Active Trials
NCT02167659Completed1,201Est. Dec 2020
NCT00766935Completed30Est. Apr 2008
FibrAlign
FibrAlignCA - Union City
2 programs
BioBridge® Collagen MatrixN/A1 trial
BioBridge® Collagen MatrixN/A1 trial
Active Trials
NCT05695924Recruiting60Est. Dec 2025
NCT04606030Recruiting60Est. Dec 2025
Solventum
SolventumMN - St. Paul
1 program
3M Coban 2N/A1 trial
Active Trials
NCT01096589Completed82Est. Oct 2010
Medical Microinstruments
1 program
Symani Surgical SystemN/A1 trial
Active Trials
NCT07311876Not Yet Recruiting30Est. Oct 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Alliance Pharmaceuticalsquality of life assessment
Alliance PharmaceuticalsGLP-1 receptor agonist
Medical MicroinstrumentsSymani Surgical System
FibrAlignBioBridge® Collagen Matrix
Koya MedicalInsight Pro Device for Diagnosis
Koya MedicalCross over Device
Tactile MedicalAdvanced Pneumatic Compression Device
Koya MedicalDayspring Active Wearable Compression System
Koya MedicalCrossover Device
Koya MedicalDayspring Active Wearable Compression System
FibrAlignBioBridge® Collagen Matrix
Tactile MedicalConservative care
Tactile MedicalAdvanced Pneumatic Compression Device
ImpediMed23-32 mmHg compression sleeve with gauntlet
Tactile MedicalFlexitouch System

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 3,209 patients across 17 trials

NCT00376597Alliance Pharmaceuticalsquality of life assessment

Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection

Start: Jun 2006Est. completion: Jun 2017568 patients
Phase 3Completed
NCT07012642Alliance PharmaceuticalsGLP-1 receptor agonist

Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema

Start: Apr 2025Est. completion: Apr 2027110 patients
Phase 1Recruiting
NCT07311876Medical MicroinstrumentsSymani Surgical System

Clinical Lymphedema Evaluation - Advancing Reconstruction of Head and Neck Lymphatics With Symani

Start: Apr 2026Est. completion: Oct 202730 patients
N/ANot Yet Recruiting
NCT05695924FibrAlignBioBridge® Collagen Matrix

Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)

Start: Nov 2023Est. completion: Dec 202560 patients
N/ARecruiting
NCT05628688Koya MedicalInsight Pro Device for Diagnosis

A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Insight® Pro Device for Evaluating Lymphatic and Venous Disorders (VOLGA)

Start: Aug 2023Est. completion: Dec 202567 patients
N/ACompleted
NCT05507346Koya MedicalCross over Device

A Clinical Study to Evaluate the Effectiveness of a Novel Portable Non-Pneumatic Active Compression Device vs. an Advanced Pneumatic Compression Device for Treating Lower Extremity Lymphedema

Start: Sep 2022Est. completion: Jan 2024121 patients
N/ACompleted
NCT04797390Tactile MedicalAdvanced Pneumatic Compression Device

A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema

Start: Sep 2021Est. completion: Dec 2024236 patients
N/ACompleted
NCT04888975Koya MedicalDayspring Active Wearable Compression System

A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery

Start: Jun 2021Est. completion: Dec 202120 patients
N/ARecruiting
NCT04908254Koya MedicalCrossover Device

A Multi-center Randomized Control Cross-over Study to Evaluate the Safety and Effectiveness of the Dayspring Active Wearable Compression Device vs. an Advanced Pneumatic Compression Device for Treating Breast Cancer Related Lymphedema

Start: Jun 2021Est. completion: Dec 202150 patients
N/ACompleted
NCT04897035Koya MedicalDayspring Active Wearable Compression System

Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema

Start: Jun 2021Est. completion: Jul 202224 patients
N/ACompleted
NCT04606030FibrAlignBioBridge® Collagen Matrix

LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)

Start: Oct 2020Est. completion: Dec 202560 patients
N/ARecruiting
NCT04116099Tactile MedicalConservative care

CVR Registry Evaluating Flexitouch Plus and Conservative Care vs Conservative Care Only for Treatment of Lymphedema

Start: Oct 2019Est. completion: Nov 202163 patients
N/ATerminated
NCT02661646Tactile MedicalAdvanced Pneumatic Compression Device

Quality of Life Changes on Lower Extremity Lymphedema Patients Using an Advanced Pneumatic Compression Device (PCD)

Start: Dec 2015Est. completion: Feb 2023249 patients
N/ATerminated
NCT02167659ImpediMed23-32 mmHg compression sleeve with gauntlet

Bioimpedance Spectroscopy Versus Tape Measure in Prevention of Lymphedema (PREVENT)

Start: Jun 2014Est. completion: Dec 20201,201 patients
N/ACompleted
NCT01239160Tactile MedicalFlexitouch System

Two Pneumatic Compression Devices in the Treatment of Lower Extremity Lymphedema

Start: Nov 2010Est. completion: Jun 2012238 patients
N/ATerminated
NCT01096589Solventum3M Coban 2

Assessment of 3M Oedema Reduction System in the Treatment of Lymphoedema Compared to Commercial Short-stretch Bandage

Start: Mar 2010Est. completion: Oct 201082 patients
N/ACompleted
NCT00766935ImpediMedThe Equivalency of the Imp SFB7+ (L-Dex U400) With the Imp XCA Device

The Equivalency of the Imp SFB7+ (L-Dex U400) With the Imp XCA Device

Start: Nov 2007Est. completion: Apr 200830 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 actively recruiting trials targeting 3,209 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.