Skip to main content

Lung Transplantation

6
Pipeline Programs
10
Companies
11
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
5
1
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Astellas
AMBISOMEApproved
amphotericin b
Astellas
Lipid-based Polyene Antifungal [EPC]injection1997
1M Part D

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
1
Amphotericin BPhase 31 trial
Active Trials
NCT00177710Completed48Est. Dec 2007
Sandoz
SandozAustria - Kundl
3 programs
2
EverolimusPhase 31 trial
standard therapyPhase 31 trial
GI and Quality of Life AssessmentN/A1 trial
Active Trials
NCT01044667Terminated3Est. Dec 2012
NCT00402532Completed190Est. Dec 2011
NCT01404325Completed130Est. Jan 2017
Corscience
CorscienceGermany - Erlangen
1 program
1
Home spirometry with data transfer via cell phonePhase 31 trial
Active Trials
NCT00536926Completed56Est. Jul 2009
Genentech
GenentechCA - Oceanside
1 program
1
mycophenolate mofetilPhase 31 trial
Active Trials
NCT01014442Completed68Est. Jun 2012
TransMedics
TransMedicsANDOVER, MA
2 programs
OCS Lung PreservationN/A1 trial
OCS Lung SystemN/A1 trial
Active Trials
NCT03343535Terminated46Est. Jul 2022
NCT03639025Active Not Recruiting458Est. Nov 2029
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Live Lung Donor Cross-sectional Cohort StudyN/A1 trial
Active Trials
NCT01524835Completed192Est. Oct 2012
One Biosciences
One BiosciencesFrance - Paris
1 program
Trifecta-Lung cfDNA-MMDx StudyN/A
Natera
NateraAUSTIN, TX
1 program
Trifecta-Lung cfDNA-MMDx StudyN/A1 trial
Active Trials
NCT05837663Recruiting600Est. Dec 2027
XVIVO
XVIVOSweden - Mölndal
1 program
Ex vivo lung perfusion with Steen Solution™PHASE_11 trial
Active Trials
NCT01190059Completed22Est. Feb 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Sandozstandard therapy
Genentechmycophenolate mofetil
CorscienceHome spirometry with data transfer via cell phone
AstellasAmphotericin B
SandozEverolimus
XVIVOEx vivo lung perfusion with Steen Solution™
NateraTrifecta-Lung cfDNA-MMDx Study
TransMedicsOCS Lung System
TransMedicsOCS Lung Preservation
Allergy TherapeuticsLive Lung Donor Cross-sectional Cohort Study
SandozGI and Quality of Life Assessment

Clinical Trials (11)

Total enrollment: 1,813 patients across 11 trials

NCT01404325Sandozstandard therapy

Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients

Start: Feb 2012Est. completion: Jan 2017130 patients
Phase 3Completed
NCT01014442Genentechmycophenolate mofetil

A Study of Mycophenolate Mofetil (CellCept) in Lung Transplant Recipients

Start: Jan 2010Est. completion: Jun 201268 patients
Phase 3Completed
NCT00536926CorscienceHome spirometry with data transfer via cell phone

Telecommunication Via Cell Phones During Post-Operative Treatment After Lung Transplantation

Start: Jul 2007Est. completion: Jul 200956 patients
Phase 3Completed
NCT00177710AstellasAmphotericin B

Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study

Start: Jan 2006Est. completion: Dec 200748 patients
Phase 3Completed
NCT00402532SandozEverolimus

Immunosuppressive Therapy With Certican (Everolimus) After Lung Transplantation

Start: Mar 2005Est. completion: Dec 2011190 patients
Phase 3Completed
NCT01190059XVIVOEx vivo lung perfusion with Steen Solution™

Normothermic Ex Vivo Lung Perfusion (EVLP) For An Improved Assessment of Donor Lungs For Transplantation

Start: Aug 2008Est. completion: Feb 201022 patients
Phase 1Completed
NCT05837663NateraTrifecta-Lung cfDNA-MMDx Study

Trifecta-Lung cfDNA-MMDx Study

Start: Nov 2023Est. completion: Dec 2027600 patients
N/ARecruiting
NCT03639025TransMedicsOCS Lung System

OCS™ Lung TOP Registry For Donor Lungs for Transplantation

Start: Dec 2018Est. completion: Nov 2029458 patients
N/AActive Not Recruiting
NCT03343535TransMedicsOCS Lung Preservation

OCS Lung System EXPAND II Trial

Start: Mar 2018Est. completion: Jul 202246 patients
N/ATerminated
NCT01524835Allergy TherapeuticsLive Lung Donor Cross-sectional Cohort Study

Live Lung Donor Cross-sectional Cohort Study

Start: Aug 2010Est. completion: Oct 2012192 patients
N/ACompleted
NCT01044667SandozGI and Quality of Life Assessment

A Gastrointestinal Quality of Life Study in Lung Transplant Recipients Converted From Mycophenolate Mofetil to Myfortic

Start: Jan 2010Est. completion: Dec 20123 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 1,813 patients
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.