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Lung Transplant

3
Pipeline Programs
7
Companies
33
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 10 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
1
thymoglobulinPhase 31 trial
Transesophageal EchocardiographyN/A1 trial
Active Trials
NCT06089434Recruiting116Est. Jul 2026
NCT00592306Withdrawn0Est. Sep 2010
MSD
MSDIreland - Ballydine
1 program
1
LetermovirPhase 2Small Molecule1 trial
Active Trials
NCT05041426Completed15Est. Mar 2025
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
LetermovirPhase 2Small Molecule
TransMedics
TransMedicsANDOVER, MA
3 programs
OCS LungN/A1 trial
OCS Lung PreservationN/A1 trial
OCS Lung SystemN/A1 trial
Active Trials
NCT06513091Recruiting10,000Est. Nov 2039
NCT01963780Completed79Est. Apr 2018
NCT07340710Not Yet Recruiting450Est. Feb 2028
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
2 programs
Blood DrawN/A5 trials
ProcedureN/A3 trials
Active Trials
NCT02743793Terminated41Est. Mar 2020
NCT02631720Completed884Est. Nov 2019
NCT02213341Terminated77Est. Jun 2016
+5 more trials
XVIVO
XVIVOSweden - Mölndal
2 programs
XPS™ with Steen Solution™N/A1 trial
XVIVO Perfusion SystemN/A1 trial
Active Trials
NCT01365429Unknown252Est. Dec 2020
NCT05101460Active Not Recruiting315Est. Apr 2029
Sanofi
SanofiPARIS, France
1 program
thymoglobulinPHASE_35 trials
Active Trials
NCT00396968Withdrawn0
NCT06066255Unknown27Est. Mar 2026
NCT03099122Completed115Est. Nov 2019
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Sanofithymoglobulin
Sanofithymoglobulin
Allergy TherapeuticsProcedure
Sanofithymoglobulin
Sanofithymoglobulin
Sanofithymoglobulin
Angeles Therapeuticsthymoglobulin
Sanofithymoglobulin
MSDLetermovir
Sanofithymoglobulin
Allergy TherapeuticsBlood Draw
Sanofithymoglobulin
Sanofithymoglobulin
Sanofithymoglobulin
Sanofithymoglobulin

Showing 15 of 32 trials with date data

Clinical Trials (33)

Total enrollment: 14,149 patients across 33 trials

NCT03099122Sanofithymoglobulin

A Study of Thymoglobuline® Induction Therapy in Adult Recipients of Donated After Cardiac Death Kidney Transplant

Start: Aug 2017Est. completion: Nov 2019115 patients
Phase 4Completed
NCT00771745Sanofithymoglobulin

Prospective Pilot Study of Pre-Transplant Thymoglobulin Administration in Living Donor Renal Transplant Recipients

Start: Sep 2008Est. completion: Jul 201011 patients
Phase 4Completed

Human Immune Responses to Yellow Fever Vaccination

Start: May 2008Est. completion: Aug 2024239 patients
Phase 4Completed
NCT00706680Sanofithymoglobulin

Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocol

Start: Feb 2008Est. completion: Jun 200930 patients
Phase 4Unknown
NCT01239563Sanofithymoglobulin

Thymoglobulin Induction in Kidney Transplant Recipients

Start: Jan 2011Est. completion: May 201640 patients
Phase 3Unknown
NCT01157949Sanofithymoglobulin

A Study to Compare the Effectiveness of a Drug That Suppresses the Immune System Called Thymoglobulin® in Preventing the Development of a Disease That Affects the Majority of Heart Transplant Recipients Called Cardiac Allograft Vasculopathy (CAV)

Start: Nov 2010Est. completion: Jan 20180
Phase 3Withdrawn

Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation

Start: Jan 2006Est. completion: Sep 20100
Phase 3Withdrawn
NCT06066255Sanofithymoglobulin

PROPHYLAXIS OF GVH IN ELDERLY PATIENTS RECEIVING HAPLOIDENTICAL ALLOGENIC HEMATOPOIETIC STEM CELL TRASNPLANTATION USE OF A LOW DOSE ANTI-LYMPHOCYTIC SERUM

Start: Mar 2024Est. completion: Mar 202627 patients
Phase 2Unknown
NCT05041426MSDLetermovir

Letermovir for CMV Prevention After Lung Transplantation

Start: Dec 2021Est. completion: Mar 202515 patients
Phase 2Completed
NCT00471848Sanofithymoglobulin

Rabbit Antithymocyte Globulin (Thymoglobuline) With Ciclosporin for Patients With Acquired Aplastic Anaemia

Start: Aug 2008Est. completion: Feb 201335 patients
Phase 2Completed

An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees

Start: Aug 2008Est. completion: Jun 2009304 patients
Phase 2Completed
NCT00709592Sanofithymoglobulin

Reduced Intensity Total Body Irradiation + Thymoglobulin Followed by Allogeneic PBSCT

Start: Jul 2008Est. completion: Jun 201742 patients
Phase 2Completed
NCT00806598Sanofithymoglobulin

Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome

Start: May 2005Est. completion: Jun 201253 patients
Phase 2Completed
NCT00117689Sanofithymoglobulin

Evaluation of Thymoglobulin Induction and Reduced Doses of Calcineurin Inhibitors on Liver Transplant Rejection

Start: Apr 2005Est. completion: Dec 200775 patients
Phase 2Completed
NCT00396968Sanofithymoglobulin

AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant for AML and MDS

0
Phase 1/2Withdrawn
NCT00409695Sanofithymoglobulin

Thymoglobulin (ATG) Dose Finding Study

Start: Dec 2006Est. completion: Aug 20071 patients
Phase 1/2Terminated
NCT00545519Sanofithymoglobulin

A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma

Start: Oct 2006Est. completion: Mar 20086 patients
Phase 1Completed
NCT07340710TransMedicsOCS Lung System

Decreasing Edema With a Novel OCS Solution Trial

Start: Mar 2026Est. completion: Feb 2028450 patients
N/ANot Yet Recruiting

US National TOP Registry

Start: Jan 2025Est. completion: Nov 203910,000 patients
N/ARecruiting
NCT06089434Angeles TherapeuticsTransesophageal Echocardiography

TEE and Dysphagia in Lung Transplantation

Start: Jul 2024Est. completion: Jul 2026116 patients
N/ARecruiting
NCT05101460XVIVOXVIVO Perfusion System

An All Comers Registry For Normothermic Ex Vivo Lung Perfusion (EVLP) as Assessment of Donor Lungs for Transplant

Start: Oct 2019Est. completion: Apr 2029315 patients
N/AActive Not Recruiting

PREDICT Cytomegalovirus (CMV)

Start: Oct 2017Est. completion: Nov 201984 patients
N/ACompleted

A Cohort Study of Operationally Tolerant Allograft Recipients

Start: Jun 2016Est. completion: Mar 202041 patients
N/ATerminated

CLAD Phenotype Specific Risk Factors and Mechanisms

Start: Dec 2015Est. completion: Nov 2019884 patients
N/ACompleted

Impact of Vaccination on Th2 Immunity in Infancy

Start: Jan 2015Est. completion: Jun 201677 patients
N/ATerminated
NCT02137876Sanofithymoglobulin

Effects of Thymoglobulin on Human B Cells

Start: Apr 2014Est. completion: Mar 20180
N/AWithdrawn
NCT01963780TransMedicsOCS Lung Preservation

International EXPAND Lung Pivotal Trial

Start: Nov 2013Est. completion: Apr 201879 patients
N/ACompleted
NCT01365429XVIVOXPS™ with Steen Solution™

Novel Lung Trial: Normothermic Ex Vivo Lung Perfusion (Evlp) As An Assessment Of Extended/Marginal Donor Lungs

Start: May 2011Est. completion: Dec 2020252 patients
N/AUnknown
NCT00970073Sanofithymoglobulin

Low Dose Thymoglobulin to Protect Kidney Function After Liver Transplant

Start: Aug 2009Est. completion: Dec 201530 patients
N/ACompleted

PET-CT Scans in Healthy Volunteers After Flu Vaccination

Start: Sep 2008Est. completion: Aug 201118 patients
N/ATerminated
NCT00842699Sanofithymoglobulin

Characterization of Immunological Profile of Renal Transplant Patients Undergoing Induction Treatment With Thymoglobulin vs. IL-2 Receptor Antagonist Basiliximab

Start: Sep 2008Est. completion: Mar 201140 patients
N/ACompleted
NCT00476229Sanofithymoglobulin

Thymoglobulin and Total Lymphoid Irradiation for Hematologic Malignancies

Start: Jun 2006Est. completion: May 200920 patients
N/ACompleted

Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-1 Research Participants

Start: Jul 2002750 patients
N/ARecruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 14,149 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.