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Lumbar Disc Herniation

4
Pipeline Programs
8
Companies
17
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
2 programs
1
TriojectionPhase 41 trial
Lumbar discectomy OpenN/A1 trial
Active Trials
NCT02441959Terminated200Est. Jul 2018
NCT02525120Unknown49Est. May 2020
Seikagaku
SeikagakuJapan - Ibaraki
1 program
1
SI-6603Phase 31 trial
Active Trials
NCT03607838Completed352Est. Mar 2023
Teijin Pharma
Teijin PharmaJapan - Tokyo
1 program
1
KTP-001Phase 1/21 trial
Active Trials
NCT01978912Completed24Est. Oct 2018
Stayble Therapeutics
Stayble TherapeuticsSweden - Gothenburg
1 program
1
Lactic AcidPhase 11 trial
Active Trials
NCT06022263Completed25Est. Sep 2024
Intrinsic Therapeutics
7 programs
Annular closureN/A1 trial
Annular closure deviceN/A1 trial
BarricaidN/A1 trial
Follow up per standard of careN/A1 trial
Incidence of Large Annular Defects in Primary Lumbar Discectomy PatientsN/A1 trial
+2 more programs
Active Trials
NCT05467072Unknown250Est. Oct 2025
NCT03986580Unknown55Est. Dec 2024
NCT01534065Completed45Est. Mar 2013
+4 more trials
Aqua Medical
Aqua MedicalCA - Pleasanton
3 programs
Control GroupN/A1 trial
Elongation Longitudinaux Avec Decoaption Osteo ArticulaireN/A1 trial
Spinal DecompressionN/A2 trials
Active Trials
NCT04760210Completed180Est. Feb 2021
NCT04930523Completed20Est. Jul 2021
NCT04860609Completed60Est. Jun 2021
+1 more trials
joimax
joimaxCA - Irvine
1 program
joimax TESSYSN/A1 trial
Active Trials
NCT01622413Withdrawn0Est. Sep 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Intrinsic Therapeutics6mm annular closure device
Spine BioPharmaTriojection
Intrinsic TherapeuticsBarricaid
SeikagakuSI-6603
Teijin PharmaKTP-001
Stayble TherapeuticsLactic Acid
Intrinsic TherapeuticsAnnular closure
Aqua MedicalElongation Longitudinaux Avec Decoaption Osteo Articulaire
Aqua MedicalSpinal Decompression
Intrinsic TherapeuticsIncidence of Large Annular Defects in Primary Lumbar Discectomy Patients
Intrinsic TherapeuticsAnnular closure device
Aqua MedicalControl Group
Aqua MedicalSpinal Decompression
Intrinsic TherapeuticsFollow up per standard of care
Spine BioPharmaLumbar discectomy Open

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 1,964 patients across 17 trials

NCT03366779Intrinsic Therapeutics6mm annular closure device

A Post Marketing Surveillance Study

Start: Jan 2018Est. completion: Dec 202420 patients
Phase 4Unknown
NCT02525120Spine BioPharmaTriojection

Post Market Non-Inferiority Study Comparing Triojection® to Discectomy for Lumbar Disc Herniation

Start: Jul 2015Est. completion: May 202049 patients
Phase 4Unknown
NCT01283438Intrinsic TherapeuticsBarricaid

A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation

Start: Dec 2010Est. completion: Jun 2025554 patients
Phase 4Unknown
NCT03607838SeikagakuSI-6603

SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)

Start: Nov 2018Est. completion: Mar 2023352 patients
Phase 3Completed
NCT01978912Teijin PharmaKTP-001

A Study to Evaluate Safety and Exploratory Efficacy of KTP-001 in Subjects With Lumbar Disc Herniation

Start: Feb 2013Est. completion: Oct 201824 patients
Phase 1/2Completed
NCT06022263Stayble TherapeuticsLactic Acid

STA363 in the Treatment of Lumbar Disc Herniation

Start: Jul 2023Est. completion: Sep 202425 patients
Phase 1Completed
NCT05467072Intrinsic TherapeuticsAnnular closure

PMCFU of an Annular Closure System

Start: Sep 2023Est. completion: Oct 2025250 patients
N/AUnknown
NCT04930523Aqua MedicalElongation Longitudinaux Avec Decoaption Osteo Articulaire

Effect of Decompression With and Without ELDOA in Lumber Disc Protrusion Patients

Start: Jun 2021Est. completion: Jul 202120 patients
N/ACompleted
NCT04860609Aqua MedicalSpinal Decompression

Compare the Effects of Decompression on Lumber Disc Protrusion Patient

Start: Apr 2021Est. completion: Jun 202160 patients
N/ACompleted
NCT03252691Intrinsic TherapeuticsIncidence of Large Annular Defects in Primary Lumbar Discectomy Patients

Incidence of Large Annular Defects in Primary Lumbar Discectomy Patients

Start: Sep 2020Est. completion: May 20210
N/AWithdrawn
NCT03986580Intrinsic TherapeuticsAnnular closure device

Study of Lumbar Discectomy With Annular Closure

Start: May 2020Est. completion: Dec 202455 patients
N/AUnknown
NCT04760210Aqua MedicalControl Group

Decompression With ELDOA on Lumbar Disc Protrusion Patient

Start: Jan 2019Est. completion: Feb 2021180 patients
N/ACompleted
NCT04701879Aqua MedicalSpinal Decompression

Spinal Decompression Therapy in Radicular Chronic Low Back Pain

Start: Nov 2018Est. completion: Feb 202140 patients
N/ACompleted
NCT03180749Intrinsic TherapeuticsFollow up per standard of care

Post-Marketing Clinical Follow-Up of a Spine Implant

Start: Mar 2017Est. completion: Sep 202490 patients
N/AUnknown
NCT02441959Spine BioPharmaLumbar discectomy Open

Full-Endoscopic vs Open Discectomy for the Treatment of Symptomatic Lumbar Herniated Disc

Start: Jun 2015Est. completion: Jul 2018200 patients
N/ATerminated
NCT01622413joimaxjoimax TESSYS

Trial to Show Non-inferiority / Superiority of an Endoscopic Transforaminal Discectomy to Standard Microdiscectomy

Start: Sep 2013Est. completion: Sep 20170
N/AWithdrawn
NCT01534065Intrinsic TherapeuticsBarricaid

Barricaid EU Post Market Study for Primary Lumbar Disc Herniation

Start: Apr 2009Est. completion: Mar 201345 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.