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Lumbar Degenerative Disc Disease

2
Pipeline Programs
8
Companies
12
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
6 programs
1
1
SB-01 For InjectionPhase 31 trial
PDS SystemPhase 21 trial
Interbody cageN/A1 trial
PureGen Osteoprogenitor Cell AllograftN/A1 trial
PureGen Osteoprogenitor Cell AllograftN/A1 trial
+1 more programs
Active Trials
NCT03647501Completed53Est. Mar 2022
NCT01293981Terminated6
NCT01294007Terminated1Est. Nov 2013
+3 more trials
Globus Medical
Globus MedicalAUDUBON, PA
2 programs
Open PLIFN/A1 trial
TRIUMPH® Lumbar Artificial DiscN/A1 trial
Active Trials
NCT01640977Completed67Est. Sep 2014
NCT01198470Completed20Est. Dec 2016
Medtronic
MedtronicNJ - Phillipsburg
1 program
DIAM™ Spinal Stabilization SystemN/A1 trial
Active Trials
NCT00456378Terminated311Est. Nov 2018
Bioventus
BioventusDURHAM, NC
1 program
Exospine shamN/A1 trial
Active Trials
NCT00744861Terminated328Est. May 2012
Nexxt Spine
Nexxt SpineIN - Noblesville
1 program
Interbody cageN/A
NuVasive
NuVasiveCA - San Diego
1 program
Open PLIFN/A
Halifax Biomedical
1 program
Radiostereometric AnalysisN/A1 trial
Active Trials
NCT01721889Unknown30Est. Jan 2016
Spineology
SpineologyMN - St. Paul
1 program
SIFS graft containment deviceN/A1 trial
Active Trials
NCT02347410Completed102Est. Mar 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Spine BioPharmaSB-01 For Injection
Spine BioPharmaPDS System
Spine BioPharmaInterbody cage
SpineologySIFS graft containment device
Halifax BiomedicalRadiostereometric Analysis
Globus MedicalOpen PLIF
Spine BioPharmaPureGen Osteoprogenitor Cell Allograft
Spine BioPharmaPureGen Osteoprogenitor Cell Allograft
Globus MedicalTRIUMPH® Lumbar Artificial Disc
BioventusExospine sham
Spine BioPharmaTotal Disc Replacement
MedtronicDIAM™ Spinal Stabilization System

Clinical Trials (12)

Total enrollment: 1,475 patients across 12 trials

NCT05516992Spine BioPharmaSB-01 For Injection

Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine

Start: Aug 2022Est. completion: Aug 2025417 patients
Phase 3Active Not Recruiting
NCT00878579Spine BioPharmaPDS System

Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease

Start: Mar 2009Est. completion: Feb 201320 patients
Phase 2Terminated
NCT03647501Spine BioPharmaInterbody cage

Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages

Start: Aug 2018Est. completion: Mar 202253 patients
N/ACompleted
NCT02347410SpineologySIFS graft containment device

Spineology Clinical Outcomes Trial: An IDE Investigation

Start: Jan 2015Est. completion: Mar 2020102 patients
N/ACompleted
NCT01721889Halifax BiomedicalRadiostereometric Analysis

Radiostereometric Analysis of Spine Arthrodesis

Start: Nov 2012Est. completion: Jan 201630 patients
N/AUnknown
NCT01640977Globus MedicalOpen PLIF

A Prospective Non-concurrent Controlled Evaluation of Open and MAS® PLIF

Start: Jun 2012Est. completion: Sep 201467 patients
N/ACompleted
NCT01294007Spine BioPharmaPureGen Osteoprogenitor Cell Allograft

Radiographic Analysis Using PureGen Versus Autologous Bone in Posterolateral Fusion (PLF)

Start: Feb 2011Est. completion: Nov 20131 patients
N/ATerminated
NCT01293981Spine BioPharmaPureGen Osteoprogenitor Cell Allograft

Radiographic and Clinical Outcomes of PureGen in Posterior Lumbar (PLIF) and Transforaminal Interbody Fusion (TLIF)

Start: Feb 20116 patients
N/ATerminated
NCT01198470Globus MedicalTRIUMPH® Lumbar Artificial Disc

TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study

Start: Sep 2010Est. completion: Dec 201620 patients
N/ACompleted
NCT00744861BioventusExospine sham

Ultrasound as Adjunct Therapy for Increasing Fusion Success After Lumbar Surgery

Start: Sep 2008Est. completion: May 2012328 patients
N/ATerminated
NCT02139527Spine BioPharmaTotal Disc Replacement

CARES Lumbar Artificial Disc Registry

Start: May 2007Est. completion: Aug 2009120 patients
N/ATerminated
NCT00456378MedtronicDIAM™ Spinal Stabilization System

Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System Versus Conservative Care

Start: Dec 2006Est. completion: Nov 2018311 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.