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Limb Girdle Muscular Dystrophy

6
Pipeline Programs
4
Companies
7
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

AskBio
AskBioNC - Durham
1 program
1
AB-1003Phase 1/21 trial
Active Trials
NCT05230459Recruiting10Est. Dec 2032
Sarepta Therapeutics
3 programs
3
SRP-6004Phase 11 trial
SRP-9003Phase 11 trial
SRP-9004Phase 11 trial
Active Trials
NCT05906251Terminated2Est. Jun 2025
NCT05876780Active Not Recruiting6Est. Aug 2028
NCT06747273Terminated4Est. Jun 2025
Spine BioPharma
Spine BioPharmaNY - New York
2 programs
2
Autologous bone marrow mononuclear cell transplantationPhase 11 trial
Stem CellPhase 11 trial
Active Trials
NCT02050776Withdrawn0Est. Dec 2013
NCT02245711Withdrawn0Est. Jun 2015
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)N/A1 trial
Active Trials
NCT03981289Completed116Est. Jun 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AskBioAB-1003
Sarepta TherapeuticsSRP-9004
Sarepta TherapeuticsSRP-6004
Sarepta TherapeuticsSRP-9003
Spine BioPharmaStem Cell
Spine BioPharmaAutologous bone marrow mononuclear cell transplantation
Colorado TherapeuticsDefining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)

Clinical Trials (7)

Total enrollment: 138 patients across 7 trials

A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

Start: May 2023Est. completion: Dec 203210 patients
Phase 1/2Recruiting

Study to Evaluate the Safety, Tolerability, and Efficacy of SRP-9004 Administered by Systemic Infusion in Limb Girdle Muscular Dystrophy Type 2D/R3 Participants in the United States

Start: Jan 2025Est. completion: Jun 20254 patients
Phase 1Terminated

A Gene Transfer Study to Evaluate the Safety, Tolerability and Efficacy of SRP-6004 in Ambulatory Participants With Limb Girdle Muscular Dystrophy, Type 2B/R2 (LGMD2B/R2, Dysferlin [DYSF] Related)

Start: May 2023Est. completion: Jun 20252 patients
Phase 1Terminated

A Gene Transfer Single Dose Study to Evaluate the Safety, Tolerability and Efficacy of SRP-9003 in Non-Ambulatory and Ambulatory Participants With Limb Girdle Muscular Dystrophy, Type 2E/R4 (Beta-Sarcoglycan [β-SG] Deficiency)

Start: Dec 2022Est. completion: Aug 20286 patients
Phase 1Active Not Recruiting

Cell Therapy in Limb Girdle Muscular Dystrophy

Start: Dec 2010Est. completion: Jun 20150
Phase 1Withdrawn
NCT02050776Spine BioPharmaAutologous bone marrow mononuclear cell transplantation

Stem Cell Therapy in Limb Girdle Muscular Dystrophy

Start: Dec 2008Est. completion: Dec 20130
Phase 1Withdrawn
NCT03981289Colorado TherapeuticsDefining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)

Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)

Start: Jun 2019Est. completion: Jun 2025116 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 138 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.