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Knee Injuries

0
Pipeline Programs
7
Companies
10
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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0
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Tissue Regenix
Tissue RegenixTX - Universal City
3 programs
OrthoPure™ XTN/A1 trial
dCELL® ACL ScaffoldN/A1 trial
dCELL® MeniscusN/A1 trial
Active Trials
NCT03562299Withdrawn0Est. Dec 2020
NCT02540811Completed40Est. Aug 2021
NCT02270905Suspended32Est. Dec 2018
Piramal Pharma
Piramal PharmaMumbai, India
2 programs
BST-CarGel with MicrofractureN/A1 trial
Microfracture with BST-CarGelN/A1 trial
Active Trials
NCT00314236Completed80Est. May 2011
NCT01246895Completed67Est. Mar 2014
Marius Pharmaceuticals
1 program
Ahead of the GameN/A1 trial
Active Trials
NCT06846008Completed320Est. Jun 2025
Shield Therapeutics
Shield TherapeuticsMA - Wellesley
1 program
B-FREEN/A1 trial
Active Trials
NCT04018638Active Not Recruiting30Est. Dec 2025
Endonovo Therapeutics
Endonovo TherapeuticsCA - Woodland Hills
1 program
Endonovo SofPulseN/A1 trial
Active Trials
NCT04109638Recruiting76Est. Feb 2027
Geistlich Pharma
Geistlich PharmaSwitzerland - Root
1 program
MicrofractureN/A1 trial
Active Trials
NCT04537013Terminated82Est. Sep 2025
KARL STORZ Endoscopy
KARL STORZ EndoscopyCA - El Segundo
1 program
Perfusion with Indocyanine greenN/A1 trial
Active Trials
NCT05072717Withdrawn0Est. Dec 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Marius PharmaceuticalsAhead of the Game
KARL STORZ EndoscopyPerfusion with Indocyanine green
Endonovo TherapeuticsEndonovo SofPulse
Geistlich PharmaMicrofracture
Shield TherapeuticsB-FREE
Tissue RegenixOrthoPure™ XT
Tissue RegenixdCELL® ACL Scaffold
Tissue RegenixdCELL® Meniscus
Piramal PharmaMicrofracture with BST-CarGel
Piramal PharmaBST-CarGel with Microfracture

Clinical Trials (10)

Total enrollment: 727 patients across 10 trials

NCT06846008Marius PharmaceuticalsAhead of the Game

The Effectiveness of a Coach-Focused Intervention on Preventing Knee Injuries in Amateur Football Players

Start: Feb 2025Est. completion: Jun 2025320 patients
N/ACompleted
NCT05072717KARL STORZ EndoscopyPerfusion with Indocyanine green

Dynamic Contrast-Enhanced Fluorescence Arthroscopy of Meniscus Pilot

Start: Jan 2022Est. completion: Dec 20230
N/AWithdrawn
NCT04109638Endonovo TherapeuticsEndonovo SofPulse

Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery

Start: Feb 2021Est. completion: Feb 202776 patients
N/ARecruiting
NCT04537013Geistlich PharmaMicrofracture

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

Start: Aug 2020Est. completion: Sep 202582 patients
N/ATerminated
NCT04018638Shield TherapeuticsB-FREE

Blood-Flow Restriction Exercise Following a Knee Replacement

Start: Jun 2019Est. completion: Dec 202530 patients
N/AActive Not Recruiting
NCT03562299Tissue RegenixOrthoPure™ XT

OrthoPure™ XT Pilot Clinical Study

Start: Jul 2018Est. completion: Dec 20200
N/AWithdrawn
NCT02540811Tissue RegenixdCELL® ACL Scaffold

Clinical Evaluation of dCELL® ACL Scaffold for Reconstruction of the Anterior Cruciate Ligament

Start: Sep 2015Est. completion: Aug 202140 patients
N/ACompleted
NCT02270905Tissue RegenixdCELL® Meniscus

Clinical Evaluation of dCELL® Meniscus for Partial Replacement of the Meniscus

Start: Oct 2014Est. completion: Dec 201832 patients
N/ASuspended
NCT01246895Piramal PharmaMicrofracture with BST-CarGel

Follow-Up Study Evaluating The Long Term Safety and Efficacy of BST-CarGel and Microfracture Repair of the Knee

Start: Mar 2011Est. completion: Mar 201467 patients
N/ACompleted
NCT00314236Piramal PharmaBST-CarGel with Microfracture

Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee

Start: Dec 2005Est. completion: May 201180 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 727 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.