Keratitis

3
Pipeline Programs
4
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

S
SantenCA - Emeryville
1 program
1
1mg/mL ciclosporinPhase 41 trial
Active Trials
NCT03237936Completed17Est. Jul 2018
Alcon
AlconFORT WORTH, TX
1 program
1
B+L Biotrue MPS and B+L PureVisionPhase 41 trial
Active Trials
NCT01268306CompletedEst. Dec 2010
Thea Pharma
Thea PharmaMA - Waltham
1 program
1
T4020Phase 31 trial
Active Trials
NCT01794312CompletedEst. Dec 2017
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
Safety of Overnight Corneal Reshaping LensesN/A1 trial
Active Trials
NCT01272271Completed1,317Est. Oct 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Santen1mg/mL ciclosporin
AlconB+L Biotrue MPS and B+L PureVision
Thea PharmaT4020
Bausch + LombSafety of Overnight Corneal Reshaping Lenses

Clinical Trials (4)

Total enrollment: 1,334 patients across 4 trials

NCT03237936Santen1mg/mL ciclosporin

Effect of IKERVIS® Eye Drops Once Daily on the Quality of Vision in Dry Eye Disease Patients With Severe Keratitis

Start: Mar 2017Est. completion: Jul 201817 patients
Phase 4Completed
NCT01268306AlconB+L Biotrue MPS and B+L PureVision

Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses

Start: Oct 2010Est. completion: Dec 2010
Phase 4Completed

Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer

Start: Feb 2013Est. completion: Dec 2017
Phase 3Completed
NCT01272271Bausch + LombSafety of Overnight Corneal Reshaping Lenses

Safety of Overnight Corneal Reshaping Lenses

Start: Feb 2008Est. completion: Oct 20101,317 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space