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Japanese Encephalitis

14
Pipeline Programs
3
Companies
29
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
11
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
11100%
+ 16 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Valneva
ValnevaAustria - Vienna
15 programs
1
11
1
IXIARO®Phase 41 trial
Blood drawPhase 31 trial
IC51Phase 31 trial
IC51Phase 31 trial
IC51Phase 31 trial
+10 more programs
Active Trials
NCT01335412Completed20,000Est. Jun 2013
NCT00596102Completed3,258
NCT01559831Withdrawn0Est. Mar 2013
+12 more trials
Medica Corp
Medica CorpMA - Bedford
1 program
1
Live Attenuated Varicella Vaccine + Live Attenuated JE VaccinePhase 4Vaccine1 trial
Active Trials
NCT01815073Completed497Est. Jul 2013
Sanofi
SanofiPARIS, France
11 programs
a live attenuated chimeric JE vaccineN/AVaccine2 trials
ChimeriVax™-JEPHASE_21 trial
ChimeriVax™-JE vaccinePHASE_2Vaccine1 trial
Japanese encephalitis vaccinePHASE_2Vaccine1 trial
Live attenuated Japanese encephalitis virus; Yellow fever virusPHASE_21 trial
+6 more programs
Active Trials
NCT02526550Completed50Est. Jul 2014
NCT02602652Completed50Est. Jul 2015
NCT00441259Completed96Est. Dec 2011
+10 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Sanofia live attenuated chimeric JE vaccine
SanofiIMOJEV®: Live attenuated Japanese encephalitis chimeric virus vaccine
Medica CorpLive Attenuated Varicella Vaccine + Live Attenuated JE Vaccine
ValnevaIXIARO®
SanofiIMOJEV
ValnevaIXIARO
ValnevaBlood draw
SanofiJE-CV Vaccine
SanofiJapanese encephalitis chimeric virus: Measles, mumps, and rubella live attenuated virus
ValnevaIC51
SanofiJapanese encephalitis vaccine
ValnevaJapanese Encephalitis purified inactivated vaccine
ValnevaIC51
ValnevaIC51
SanofiChimeriVax™-JE

Showing 15 of 29 trials with date data

Clinical Trials (29)

Total enrollment: 44,114 patients across 29 trials

NCT02526550Sanofia live attenuated chimeric JE vaccine

Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX

Start: Jun 2014Est. completion: Jul 201450 patients
Phase 4Completed
NCT01981967SanofiIMOJEV®: Live attenuated Japanese encephalitis chimeric virus vaccine

Post-licensure Safety Study of IMOJEV® in Thailand

Start: Nov 2013Est. completion: Oct 201510,000 patients
Phase 4Completed
NCT01815073Medica CorpLive Attenuated Varicella Vaccine + Live Attenuated JE Vaccine

Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine

Start: Mar 2013Est. completion: Jul 2013497 patients
Phase 4Completed

This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population

Start: Jun 2010Est. completion: Oct 2011200 patients
Phase 4Completed

Study of a Booster Dose of IMOJEV® One Year After Primary Immunization in Healthy Children in South Korea

Start: Jul 2013Est. completion: Mar 2014119 patients
Phase 3Completed

Open-label, Randomized Study in a Pediatric Population in a JEV (Japanese Encephalitis Virus)-Endemic Country

Start: Dec 2010Est. completion: Oct 2013300 patients
Phase 3Completed

Long Term Immunity and Safety Following Vaccination With the JEV IC51 (IXIARO®, JESPECT®) in Pediatric Population In Non Endemic Countries. Uncontrolled, Ph3 FU-Study

Start: Oct 2010Est. completion: Sep 201423 patients
Phase 3Completed
NCT01190228SanofiJE-CV Vaccine

Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Previously Immunized With JE-CV

Start: Aug 2010Est. completion: Oct 2015454 patients
Phase 3Completed
NCT01188343SanofiJapanese encephalitis chimeric virus: Measles, mumps, and rubella live attenuated virus

Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers

Start: Aug 2010Est. completion: Dec 2012542 patients
Phase 3Completed

Immunogenicity of a Commercial Batch of JEV IC51 up to 24 Months Post Filling

Start: Sep 2008Est. completion: Jun 2010304 patients
Phase 3Completed
NCT00735644SanofiJapanese encephalitis vaccine

Study of ChimeriVax™-Japanese Encephalitis Vaccine in Toddlers in Thailand and the Philippines

Start: Aug 2008Est. completion: Aug 20091,200 patients
Phase 3Completed
NCT00595465ValnevaJapanese Encephalitis purified inactivated vaccine

Comparison of Three Commercial Batches of the Japanese Encephalitis Vaccine IC51

Start: Dec 2007Est. completion: Jun 2008389 patients
Phase 3Completed

Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51

Start: Dec 2007Est. completion: Oct 2009198 patients
Phase 3Completed

Comparison of Three Batches of the Japanese Encephalitis Vaccine IC51

Start: Sep 2006Est. completion: Sep 2007639 patients
Phase 3Completed
NCT00314145SanofiChimeriVax™-JE

A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVax™-JE and JE-VAX

Start: Nov 2005Est. completion: Nov 2006820 patients
Phase 3Completed
NCT00605085ValnevaJapanese Encephalitis purified inactivated vaccine

Safety and Tolerability of the Japanese Encephalitis Vaccine IC51

Start: Oct 2005Est. completion: Nov 20062,675 patients
Phase 3Completed

Long Term Persistence and Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51

Start: Oct 2005Est. completion: Apr 2009349 patients
Phase 3Completed

Immunogenicity Study of the Japanese Encephalitis Vaccine IC51

Start: Sep 2005Est. completion: Sep 2006867 patients
Phase 3Completed

Concomitant Vaccination With the Japanese Encephalitis Vaccine IC51 and HARVIX® 1440

Start: Sep 2005Est. completion: Aug 2008192 patients
Phase 3Completed

Rapid Immunization Study of the Japanese Encephalitis Vaccine IC51

Start: Sep 2005Est. completion: Nov 2007374 patients
Phase 3Completed
NCT00621764SanofiJapanese encephalitis vaccine

Immunogenicity and Safety of ChimeriVax™ Japanese Encephalitis Vaccine in Thai Toddlers and Children

Start: Mar 2008Est. completion: May 2013300 patients
Phase 2Completed
NCT00441259SanofiChimeriVax™-JE

Safety and Efficacy Study of ChimeriVax™-JE and JE Inactivated Mouse Brain Vaccine in Children of Descending Age

Start: Jan 2007Est. completion: Dec 201196 patients
Phase 2Completed
NCT00319592SanofiChimeriVax™-JE vaccine

A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVaxTM-JE and JE-VAX

Start: May 2005Est. completion: Sep 200660 patients
Phase 2Completed
NCT00982137SanofiLive attenuated Japanese encephalitis virus; Yellow fever virus

Study of Live Attenuated Japanese Encephalitis Vaccine (ChimeriVax™-JE) and Yellow Fever Vaccine (STAMARIL®)

Start: Jul 2004Est. completion: Mar 2007108 patients
Phase 2Completed

Immune Response in IXIARO Batch JEV09L37 Recipients Before and After Revaccination

Start: Jun 2012Est. completion: Mar 20130
Phase 1Withdrawn

Postmarketing Surveillance Study for IMOJEV® in Republic of Korea

Start: Jul 2016Est. completion: Oct 201850 patients
N/ACompleted
NCT02602652Sanofia live attenuated chimeric JE vaccine

Immunogenicity of a JE-CV as a Booster Dose After a Primary Vaccination With SA14-14-2 Vaccine

Start: Dec 2013Est. completion: Jul 201550 patients
N/ACompleted
NCT01335412ValnevaJapanese Encephalitis Virus vaccine, inactivated, adsorbed

Safety Surveillance After Immunization With IXIARO

Start: Mar 2011Est. completion: Jun 201320,000 patients
N/ACompleted
NCT00596102ValnevaJapanese Encephalitis purified inactivated vaccine

Longterm Immunogenicity of the Japanese Encephalitis Vaccine IC51

Start: Oct 20053,258 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

11 late-stage (Phase 3) programs, potential near-term approvals
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.