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Intervertebral Disc Degeneration

2
Pipeline Programs
5
Companies
7
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Biocorp
BiocorpFrance - Issoire
2 programs
2
Autologous BM-MSCPhase 21 trial
Autologous BM-MSCPhase 21 trial
Active Trials
NCT04759105Completed48Est. Nov 2023
NCT05066334Recruiting52Est. Oct 2025
Medtronic
MedtronicNJ - Phillipsburg
3 programs
INFUSE™ Bone GraftN/A1 trial
Lumbar fusionN/A1 trial
Minimally invasive lumbar fusionN/A1 trial
Active Trials
NCT05299762Recruiting600Est. Aug 2025
NCT04408846Withdrawn0Est. Dec 2023
NCT02617563Completed361Est. Nov 2024
Proprio
ProprioWA - Seattle
1 program
Intraoperative spinal measurement systemN/A1 trial
Active Trials
NCT07023393Withdrawn0Est. Apr 2029
Spine BioPharma
Spine BioPharmaNY - New York
1 program
Somatosensory evoked potential [SSEP] intraoperative monitoringN/A1 trial
Active Trials
NCT05648474Recruiting400Est. Dec 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
BiocorpAutologous BM-MSC
BiocorpAutologous BM-MSC
ProprioIntraoperative spinal measurement system
MedtronicINFUSE™ Bone Graft
Spine BioPharmaSomatosensory evoked potential [SSEP] intraoperative monitoring
MedtronicLumbar fusion
MedtronicMinimally invasive lumbar fusion

Clinical Trials (7)

Total enrollment: 1,461 patients across 7 trials

NCT05066334BiocorpAutologous BM-MSC

Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD

Start: Mar 2021Est. completion: Oct 202552 patients
Phase 2Recruiting
NCT04759105BiocorpAutologous BM-MSC

Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD

Start: Nov 2019Est. completion: Nov 202348 patients
Phase 2Completed
NCT07023393ProprioIntraoperative spinal measurement system

Proprio Spine Measurement Tool

Start: Apr 2026Est. completion: Apr 20290
N/AWithdrawn
NCT05299762MedtronicINFUSE™ Bone Graft

A Post Market Surveillance on INFUSE Bone Graft

Start: Aug 2022Est. completion: Aug 2025600 patients
N/ARecruiting
NCT05648474Spine BioPharmaSomatosensory evoked potential [SSEP] intraoperative monitoring

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

Start: Jul 2022Est. completion: Dec 2025400 patients
N/ARecruiting
NCT04408846MedtronicLumbar fusion

Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis

Start: Dec 2020Est. completion: Dec 20230
N/AWithdrawn
NCT02617563MedtronicMinimally invasive lumbar fusion

5-Year Global Study on MAST™ Minimally Invasive Fusion Procedures to Treat Degenerative Lumbar Spine (MASTERS-D2)

Start: Dec 2015Est. completion: Nov 2024361 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 1,461 patients
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.