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Infections, Streptococcal

52
Pipeline Programs
4
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
9
0
38
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
68100%
+ 52 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
60 programs
4
8
38
1
GSK1024850APhase 4
10 valent pneumococcal conjugatePhase 3
GSK Biologicals' 10-valent pneumococcal conjugate vaccine.Phase 3Vaccine
GSK Biologicals' Synflorix™Phase 3
GSK Biologicals' Synflorix™Phase 3
+55 more programs
Sandoz
SandozAustria - Kundl
1 program
1
GBS VaccinePhase 2Vaccine1 trial
Active Trials
NCT02270944Completed1,053Est. Sep 2015
GSK
GSKLONDON, United Kingdom
58 programs
BAL fluid samplingN/A1 trial
Data collectionN/A1 trial
Data collectionN/A1 trial
Middle ear fluid and urine.N/A1 trial
Sample collectionN/A1 trial
+53 more programs
Active Trials
NCT02838407Completed197Est. Sep 2015
NCT01793857Completed1,330Est. May 2013
NCT01365390Completed2,258Est. Dec 2012
+54 more trials
Novartis
NovartisBASEL, Switzerland
1 program
GBS VaccinePHASE_2Vaccine

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKGSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKSynflorix™
GSKSynflorix
GSKGSK1024850A
GSKSynflorix™
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal conjugate vaccine GSK 1024850A
GSKGSK Biologicals' Synflorix™
GSKPneumococcal conjugate vaccine GSK1024850A

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 93,254 patients across 50 trials

NCT01235949GSKGSK1024850A

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment

Start: Nov 2010Est. completion: Dec 2012850 patients
Phase 4Completed
NCT02447432GSKPneumococcal vaccine GSK1024850A

A Study to Compare the Immunogenicity of GSK Biologicals' 10Pn-PD-DiT 4-dose Presentation to the Licensed 1-dose Synflorix™ (10Pn-PD-DiT) Vaccine When Co-administered With DTPw-combination Vaccine in Healthy Infants

Start: Jun 2015Est. completion: May 2016320 patients
Phase 3Completed
NCT01746108GSKSynflorix™

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Pneumococcal Vaccine (Synflorix™) When Administered to Children Who Are at an Increased Risk of Pneumococcal Infection

Start: Jun 2013Est. completion: Jun 201552 patients
Phase 3Completed

Primary Vaccination With Either Synflorix™ or Prevenar 13™ or Both Vaccines and Booster Vaccination With Synflorix™

Start: Sep 2012Est. completion: May 2014457 patients
Phase 3Completed
NCT01175083GSKGSK1024850A

Immunization of Children Between 8 Weeks and 2 Years of Age With GSK Pneumococcal Vaccine GSK1024850A

Start: Jun 2011Est. completion: May 2013300 patients
Phase 3Completed
NCT01153841GSKSynflorix™

Primary Vaccination Study With GSK Biologicals' Pneumococcal Vaccine in Healthy Infants in Vietnam

Start: Feb 2011Est. completion: Jul 2011300 patients
Phase 3Completed
NCT01153893GSKPneumococcal vaccine GSK1024850A

Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Nigeria

Start: Oct 2010Est. completion: Feb 2011105 patients
Phase 3Completed
NCT01119625GSKPneumococcal vaccine GSK1024850A

Immunological Persistence After Priming With GSK1024850A Vaccine and Safety& Immunogenicity After Booster Dose

Start: Jul 2010Est. completion: Feb 2011238 patients
Phase 3Completed
NCT01030822GSKPneumococcal vaccine GSK1024850A

Booster and Catch-up Vaccination With Vaccine GSK1024850A

Start: Apr 2010Est. completion: Aug 2011282 patients
Phase 3Completed
NCT01027845GSKPneumococcal vaccine GSK1024850A

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A in Healthy Japanese Children

Start: Dec 2009Est. completion: Sep 2011360 patients
Phase 3Completed
NCT00985465GSKPneumococcal vaccine GSK1024850A

Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Mali

Start: Nov 2009Est. completion: Jul 2010218 patients
Phase 3Completed
NCT00950833GSKPneumococcal vaccine GSK1024850A

Long-term Follow-up Study of Children Previously Primed With GSK Pneumococcal Vaccine (GSK1024850A) and of Unprimed Children

Start: Aug 2009Est. completion: Oct 2010466 patients
Phase 3Completed
NCT00907777GSKPneumococcal conjugate vaccine GSK 1024850A

Vaccination With GSK 1024850A in Children Primed With GSK 1024850A & Boosted With Pneumovax 23™

Start: Jun 2009Est. completion: Oct 200952 patients
Phase 3Completed
NCT00911144GSKGSK Biologicals' Synflorix™

Booster Vaccination Study With a Pneumococcal Vaccine in Children Primed With the Same Vaccine

Start: Jun 2009Est. completion: Jan 2010450 patients
Phase 3Completed
NCT00861380GSKPneumococcal conjugate vaccine GSK1024850A

Evaluation of Effectiveness of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Against Invasive Disease

Start: May 2009Est. completion: Oct 201341,188 patients
Phase 3Completed
NCT00814710GSKPneumococcal conjugate vaccine GSK1024850A

Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6 to 10 Weeks of Age

Start: Mar 2009Est. completion: Nov 2009360 patients
Phase 3Completed
NCT00839254GSKPneumococcal conjugate vaccine Synflorix

Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A

Start: Feb 2009Est. completion: Jan 20126,181 patients
Phase 3Completed
NCT00829010GSKPneumococcal vaccine GSK1024850A

Primary and Booster Vaccination Study With a Pneumococcal Vaccine in HIV Infected, HIV Exposed Uninfected and HIV Uninfected Children 6 to 10 Weeks of Age.

Start: Feb 2009Est. completion: Jun 2012489 patients
Phase 3Completed
NCT00808444GSKPneumococcal conjugate vaccine GSK1024850A

Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6-12wks of Age

Start: Jan 2009Est. completion: Nov 2009466 patients
Phase 3Completed
NCT00792909GSKPneumococcal conjugate vaccine GSK1024850A

Vaccination Course in Primed Children and Age-matched Unprimed Children With Pneumococcal Vaccine GSK1024850A

Start: Dec 2008Est. completion: Jul 2009172 patients
Phase 3Completed
NCT00678301GSKGSK Biologicals' Synflorix™

Primary Vaccination Course in Children Receiving the Pneumococcal Vaccine GSK 1024850A, Zilbrix™ Hib and Polio Sabin™

Start: Jun 2008Est. completion: Dec 2009365 patients
Phase 3Completed
NCT00680914GSKPneumococcal vaccine GSK1024850A

Primary Vaccination Course in Children Receiving Pneumococcal Conjugate Vaccine GSK 1024850A or Prevenar™ and Hiberix™

Start: Jun 2008Est. completion: May 2009503 patients
Phase 3Completed
NCT00652951GSKGSK Biologicals´ Pneumococcal Conjugate Vaccine GSK1024850A

Co-administration of Pneumococcal Conjugate Vaccine With DTPa-IPV-Hib Versus Co-administration With DTPa-HBV-IPV/Hib

Start: Apr 2008Est. completion: Dec 2010780 patients
Phase 3Completed
NCT00624819GSKGSK1024805A

Assessment of Antibody Persistence in Children Previously Vaccinated With Pneumococcal Conjugate Vaccine

Start: Mar 2008Est. completion: Jun 2008524 patients
Phase 3Completed
NCT00609492GSKGSK Biologicals´ Pneumococcal Conjugate Vaccine

Evaluate Safety and Immunogenicity of a Booster Dose of Pneumococcal Conjugate Vaccine in Preterm Born Infants.

Start: Jan 2008Est. completion: Mar 2009245 patients
Phase 3Completed

Pneumococcal Vaccine Booster Study in Healthy Children 12-18 Mths Old Previously Primed With the Same Vaccines

Start: Oct 2007Est. completion: Oct 2008756 patients
Phase 3Completed

Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6 to 12wks of Age

Start: Jul 2007Est. completion: Mar 2008230 patients
Phase 3Completed
NCT00496015GSKPneumococcal conjugate vaccine GSK1024850A.

Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A

Start: Jul 2007Est. completion: Feb 2009750 patients
Phase 3Completed
NCT00466947GSKPneumococcal conjugate vaccine GSK1024850A

COMPAS (Clinical Otitis Media & Pneumonia Study): Pneumonia & Acute Otitis Media (AOM ) Efficacy Study of the Pneumococcal Conjugate Vaccine

Start: Jun 2007Est. completion: Jul 201123,802 patients
Phase 3Completed
NCT00370227GSK10 valent pneumococcal conjugate

Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Oct 2006Est. completion: Mar 2007390 patients
Phase 3Completed
NCT00390910GSKPneumococcal conjugate vaccine GSK1024850A

Study to Evaluate the Safety and Immunogenicity of a 10-valent Pneumococcal Conjugate Vaccine in Preterm Infants

Start: Oct 2006Est. completion: May 2008286 patients
Phase 3Completed

Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine.

Start: Sep 2006Est. completion: Nov 20071,200 patients
Phase 3Completed

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Sep 2006Est. completion: Nov 2007600 patients
Phase 3Completed
NCT00344318GSKPneumococcal conjugate vaccine GSK1024850A

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Aug 2006Est. completion: Oct 2007806 patients
Phase 3Completed
NCT00333450GSKPneumococcal vaccine

Immune Memory Evaluation in Children Following a Primary Vaccination With Pneumococcal Conjugate Vaccines.

Start: Aug 2006Est. completion: Dec 2006120 patients
Phase 3Completed
NCT00334334GSKPneumococcal

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine.

Start: Jun 2006Est. completion: Aug 20071,572 patients
Phase 3Completed
NCT00307034GSKGSK Biologicals' 10-valent pneumococcal conjugate vaccine.

Safety & Immunogenicity Study of 10-Valent Pneumococcal Conjugate Vaccine When Administered as a 2-Dose Schedule

Start: Jan 2006Est. completion: Jan 2007351 patients
Phase 3Completed
NCT00307554GSKPneumococcal

A Lot-to-lot Consistency (3 Lots of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine) & Non-inferiority Study

Start: Nov 2005Est. completion: Jun 20061,600 patients
Phase 3Completed
NCT00307541GSKPneumococcal

Assess the Immunogenicity of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Oct 2005Est. completion: Apr 2006120 patients
Phase 3Completed

Safety and Immunogenicity of the Liquid Formulation of Group B Streptococcus Trivalent Vaccine and of the Lyophilized Formulation of Group B Streptococcus Trivalent Vaccine

Start: Nov 2014Est. completion: Sep 20151,053 patients
Phase 2Completed
NCT01616459GSKPneumococcal conjugate vaccine GSK2830929A

Immunogenicity and Safety of Two Formulations of GSK Biologicals' Pneumococcal Vaccine (2830929A and 2830930A) When Administered in Healthy Infants

Start: Jul 2012Est. completion: Jan 2014953 patients
Phase 2Completed
NCT01262872GSKPneumococcal vaccine GSK 2189242A

Impact of GSK Biologicals' 2189242A Vaccine on Nasopharyngeal Carriage, Safety & Immunogenicity in Children & Infants

Start: Feb 2011Est. completion: Mar 20131,320 patients
Phase 2Completed
NCT01204658GSKPneumococcal vaccine GSK 2189242A

Safety & Immunogenicity of Pneumococcal Vaccine 2189242A Co-administered With DTPa-HBV-IPV/Hib in Healthy Infants

Start: Sep 2010Est. completion: Oct 2012576 patients
Phase 2Completed
NCT00985751GSKPneumococcal vaccine GSK2189242A

Safety & Immunogenicity of Pneumococcal Vaccine 2189242A in Children Aged 12-23 Months at the Time of First Vaccination

Start: Nov 2009Est. completion: Mar 2011257 patients
Phase 2Completed
NCT00896064GSKPneumococcal vaccine GSK2189242A

Evaluation of a Booster Dose of Pneumococcal Vaccine Formulations in Young Adults

Start: May 2009Est. completion: Aug 200943 patients
Phase 2Completed

Assess Reacto- and Immunogenicity of Pneumococcal Conjugate Vaccine When Given as Booster or a 2 Dose Catch up Schedule

Start: Aug 2007Est. completion: Aug 2008163 patients
Phase 2Completed
NCT01485406GSKPneumococcal vaccine GSK2830930A

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Pneumococcal Vaccine 2830930A Administered in Toddlers

Start: Dec 2011Est. completion: Mar 201261 patients
Phase 1Completed
NCT00756067GSKPneumococcal vaccine GSK2189241A

Evaluation of Pneumococcal Vaccine Formulations in Elderly

Start: Sep 2008Est. completion: May 2009168 patients
Phase 1Completed
NCT00707798GSKPneumococcal vaccine GSK2189242A

Evaluation of Pneumococcal Vaccine Formulations in Young Adults

Start: Jun 2008Est. completion: Jan 2009157 patients
Phase 1Completed
NCT02838407GSKBAL fluid sampling

Identification and Characterization of Bacteria in the Lungs of Children From 6 Months up to 6 Years Old, With Suspected Infection of the Lungs, in Spain.

Start: Sep 2013Est. completion: Sep 2015197 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

38 late-stage (Phase 3) programs, potential near-term approvals
Vaccine is the dominant modality (100% of programs)
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.