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Infections, Streptococcal

52
Pipeline Programs
4
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
9
0
38
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
68100%
+ 52 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
60 programs
4
8
38
1
GSK1024850APhase 4
10 valent pneumococcal conjugatePhase 3
GSK Biologicals' 10-valent pneumococcal conjugate vaccine.Phase 3Vaccine
GSK Biologicals' Synflorix™Phase 3
GSK Biologicals' Synflorix™Phase 3
+55 more programs
Sandoz
SandozAustria - Kundl
1 program
1
GBS VaccinePhase 2Vaccine
GSK
GSKLONDON, United Kingdom
58 programs
BAL fluid samplingN/A1 trial
Data collectionN/A1 trial
Data collectionN/A1 trial
Middle ear fluid and urine.N/A1 trial
Sample collectionN/A1 trial
+53 more programs
Active Trials
NCT02838407Completed197Est. Sep 2015
NCT01793857Completed1,330Est. May 2013
NCT01365390Completed2,258Est. Dec 2012
+54 more trials
Novartis
NovartisBASEL, Switzerland
1 program
GBS VaccinePHASE_2Vaccine3 trials
Active Trials
NCT02270944Completed1,053Est. Sep 2015
NCT01053767Completed95Est. Dec 2010
NCT01052935Completed50Est. Oct 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKGSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKSynflorix™
GSKSynflorix
GSKGSK1024850A
GSKSynflorix™
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal vaccine GSK1024850A
GSKPneumococcal conjugate vaccine GSK 1024850A
GSKGSK Biologicals' Synflorix™
GSKPneumococcal conjugate vaccine GSK1024850A

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 93,045 patients across 50 trials

NCT01235949GSKGSK1024850A

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment

Start: Nov 2010Est. completion: Dec 2012850 patients
Phase 4Completed
NCT02447432GSKPneumococcal vaccine GSK1024850A

A Study to Compare the Immunogenicity of GSK Biologicals' 10Pn-PD-DiT 4-dose Presentation to the Licensed 1-dose Synflorix™ (10Pn-PD-DiT) Vaccine When Co-administered With DTPw-combination Vaccine in Healthy Infants

Start: Jun 2015Est. completion: May 2016320 patients
Phase 3Completed
NCT01746108GSKSynflorix™

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Pneumococcal Vaccine (Synflorix™) When Administered to Children Who Are at an Increased Risk of Pneumococcal Infection

Start: Jun 2013Est. completion: Jun 201552 patients
Phase 3Completed

Primary Vaccination With Either Synflorix™ or Prevenar 13™ or Both Vaccines and Booster Vaccination With Synflorix™

Start: Sep 2012Est. completion: May 2014457 patients
Phase 3Completed
NCT01175083GSKGSK1024850A

Immunization of Children Between 8 Weeks and 2 Years of Age With GSK Pneumococcal Vaccine GSK1024850A

Start: Jun 2011Est. completion: May 2013300 patients
Phase 3Completed
NCT01153841GSKSynflorix™

Primary Vaccination Study With GSK Biologicals' Pneumococcal Vaccine in Healthy Infants in Vietnam

Start: Feb 2011Est. completion: Jul 2011300 patients
Phase 3Completed
NCT01153893GSKPneumococcal vaccine GSK1024850A

Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Nigeria

Start: Oct 2010Est. completion: Feb 2011105 patients
Phase 3Completed
NCT01119625GSKPneumococcal vaccine GSK1024850A

Immunological Persistence After Priming With GSK1024850A Vaccine and Safety& Immunogenicity After Booster Dose

Start: Jul 2010Est. completion: Feb 2011238 patients
Phase 3Completed
NCT01030822GSKPneumococcal vaccine GSK1024850A

Booster and Catch-up Vaccination With Vaccine GSK1024850A

Start: Apr 2010Est. completion: Aug 2011282 patients
Phase 3Completed
NCT01027845GSKPneumococcal vaccine GSK1024850A

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A in Healthy Japanese Children

Start: Dec 2009Est. completion: Sep 2011360 patients
Phase 3Completed
NCT00985465GSKPneumococcal vaccine GSK1024850A

Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Mali

Start: Nov 2009Est. completion: Jul 2010218 patients
Phase 3Completed
NCT00950833GSKPneumococcal vaccine GSK1024850A

Long-term Follow-up Study of Children Previously Primed With GSK Pneumococcal Vaccine (GSK1024850A) and of Unprimed Children

Start: Aug 2009Est. completion: Oct 2010466 patients
Phase 3Completed
NCT00907777GSKPneumococcal conjugate vaccine GSK 1024850A

Vaccination With GSK 1024850A in Children Primed With GSK 1024850A & Boosted With Pneumovax 23™

Start: Jun 2009Est. completion: Oct 200952 patients
Phase 3Completed
NCT00911144GSKGSK Biologicals' Synflorix™

Booster Vaccination Study With a Pneumococcal Vaccine in Children Primed With the Same Vaccine

Start: Jun 2009Est. completion: Jan 2010450 patients
Phase 3Completed
NCT00861380GSKPneumococcal conjugate vaccine GSK1024850A

Evaluation of Effectiveness of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Against Invasive Disease

Start: May 2009Est. completion: Oct 201341,188 patients
Phase 3Completed
NCT00814710GSKPneumococcal conjugate vaccine GSK1024850A

Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6 to 10 Weeks of Age

Start: Mar 2009Est. completion: Nov 2009360 patients
Phase 3Completed
NCT00839254GSKPneumococcal conjugate vaccine Synflorix

Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A

Start: Feb 2009Est. completion: Jan 20126,181 patients
Phase 3Completed
NCT00829010GSKPneumococcal vaccine GSK1024850A

Primary and Booster Vaccination Study With a Pneumococcal Vaccine in HIV Infected, HIV Exposed Uninfected and HIV Uninfected Children 6 to 10 Weeks of Age.

Start: Feb 2009Est. completion: Jun 2012489 patients
Phase 3Completed
NCT00808444GSKPneumococcal conjugate vaccine GSK1024850A

Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6-12wks of Age

Start: Jan 2009Est. completion: Nov 2009466 patients
Phase 3Completed
NCT00792909GSKPneumococcal conjugate vaccine GSK1024850A

Vaccination Course in Primed Children and Age-matched Unprimed Children With Pneumococcal Vaccine GSK1024850A

Start: Dec 2008Est. completion: Jul 2009172 patients
Phase 3Completed
NCT00678301GSKGSK Biologicals' Synflorix™

Primary Vaccination Course in Children Receiving the Pneumococcal Vaccine GSK 1024850A, Zilbrix™ Hib and Polio Sabin™

Start: Jun 2008Est. completion: Dec 2009365 patients
Phase 3Completed
NCT00680914GSKPneumococcal vaccine GSK1024850A

Primary Vaccination Course in Children Receiving Pneumococcal Conjugate Vaccine GSK 1024850A or Prevenar™ and Hiberix™

Start: Jun 2008Est. completion: May 2009503 patients
Phase 3Completed
NCT00652951GSKGSK Biologicals´ Pneumococcal Conjugate Vaccine GSK1024850A

Co-administration of Pneumococcal Conjugate Vaccine With DTPa-IPV-Hib Versus Co-administration With DTPa-HBV-IPV/Hib

Start: Apr 2008Est. completion: Dec 2010780 patients
Phase 3Completed
NCT00624819GSKGSK1024805A

Assessment of Antibody Persistence in Children Previously Vaccinated With Pneumococcal Conjugate Vaccine

Start: Mar 2008Est. completion: Jun 2008524 patients
Phase 3Completed
NCT00609492GSKGSK Biologicals´ Pneumococcal Conjugate Vaccine

Evaluate Safety and Immunogenicity of a Booster Dose of Pneumococcal Conjugate Vaccine in Preterm Born Infants.

Start: Jan 2008Est. completion: Mar 2009245 patients
Phase 3Completed

Pneumococcal Vaccine Booster Study in Healthy Children 12-18 Mths Old Previously Primed With the Same Vaccines

Start: Oct 2007Est. completion: Oct 2008756 patients
Phase 3Completed

Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6 to 12wks of Age

Start: Jul 2007Est. completion: Mar 2008230 patients
Phase 3Completed
NCT00496015GSKPneumococcal conjugate vaccine GSK1024850A.

Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A

Start: Jul 2007Est. completion: Feb 2009750 patients
Phase 3Completed
NCT00466947GSKPneumococcal conjugate vaccine GSK1024850A

COMPAS (Clinical Otitis Media & Pneumonia Study): Pneumonia & Acute Otitis Media (AOM ) Efficacy Study of the Pneumococcal Conjugate Vaccine

Start: Jun 2007Est. completion: Jul 201123,802 patients
Phase 3Completed
NCT00390910GSKPneumococcal conjugate vaccine GSK1024850A

Study to Evaluate the Safety and Immunogenicity of a 10-valent Pneumococcal Conjugate Vaccine in Preterm Infants

Start: Oct 2006Est. completion: May 2008286 patients
Phase 3Completed
NCT00370227GSK10 valent pneumococcal conjugate

Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Oct 2006Est. completion: Mar 2007390 patients
Phase 3Completed

Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine.

Start: Sep 2006Est. completion: Nov 20071,200 patients
Phase 3Completed

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Sep 2006Est. completion: Nov 2007600 patients
Phase 3Completed
NCT00344318GSKPneumococcal conjugate vaccine GSK1024850A

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Aug 2006Est. completion: Oct 2007806 patients
Phase 3Completed
NCT00333450GSKPneumococcal vaccine

Immune Memory Evaluation in Children Following a Primary Vaccination With Pneumococcal Conjugate Vaccines.

Start: Aug 2006Est. completion: Dec 2006120 patients
Phase 3Completed
NCT00334334GSKPneumococcal

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine.

Start: Jun 2006Est. completion: Aug 20071,572 patients
Phase 3Completed
NCT00307034GSKGSK Biologicals' 10-valent pneumococcal conjugate vaccine.

Safety & Immunogenicity Study of 10-Valent Pneumococcal Conjugate Vaccine When Administered as a 2-Dose Schedule

Start: Jan 2006Est. completion: Jan 2007351 patients
Phase 3Completed
NCT00307554GSKPneumococcal

A Lot-to-lot Consistency (3 Lots of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine) & Non-inferiority Study

Start: Nov 2005Est. completion: Jun 20061,600 patients
Phase 3Completed
NCT00307541GSKPneumococcal

Assess the Immunogenicity of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine

Start: Oct 2005Est. completion: Apr 2006120 patients
Phase 3Completed

Safety and Immunogenicity of the Liquid Formulation of Group B Streptococcus Trivalent Vaccine and of the Lyophilized Formulation of Group B Streptococcus Trivalent Vaccine

Start: Nov 2014Est. completion: Sep 20151,053 patients
Phase 2Completed
NCT01616459GSKPneumococcal conjugate vaccine GSK2830929A

Immunogenicity and Safety of Two Formulations of GSK Biologicals' Pneumococcal Vaccine (2830929A and 2830930A) When Administered in Healthy Infants

Start: Jul 2012Est. completion: Jan 2014953 patients
Phase 2Completed
NCT01262872GSKPneumococcal vaccine GSK 2189242A

Impact of GSK Biologicals' 2189242A Vaccine on Nasopharyngeal Carriage, Safety & Immunogenicity in Children & Infants

Start: Feb 2011Est. completion: Mar 20131,320 patients
Phase 2Completed
NCT01204658GSKPneumococcal vaccine GSK 2189242A

Safety & Immunogenicity of Pneumococcal Vaccine 2189242A Co-administered With DTPa-HBV-IPV/Hib in Healthy Infants

Start: Sep 2010Est. completion: Oct 2012576 patients
Phase 2Completed
NCT00985751GSKPneumococcal vaccine GSK2189242A

Safety & Immunogenicity of Pneumococcal Vaccine 2189242A in Children Aged 12-23 Months at the Time of First Vaccination

Start: Nov 2009Est. completion: Mar 2011257 patients
Phase 2Completed
NCT00896064GSKPneumococcal vaccine GSK2189242A

Evaluation of a Booster Dose of Pneumococcal Vaccine Formulations in Young Adults

Start: May 2009Est. completion: Aug 200943 patients
Phase 2Completed

Assess Reacto- and Immunogenicity of Pneumococcal Conjugate Vaccine When Given as Booster or a 2 Dose Catch up Schedule

Start: Aug 2007Est. completion: Aug 2008163 patients
Phase 2Completed
NCT01485406GSKPneumococcal vaccine GSK2830930A

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Pneumococcal Vaccine 2830930A Administered in Toddlers

Start: Dec 2011Est. completion: Mar 201261 patients
Phase 1Completed

A Study to Assess the Persistence of a GBS Antibody in Women Previously Immunized With a GBS Vaccine

Start: Jan 2010Est. completion: Oct 201050 patients
Phase 1Completed

A Study to Assess the Persistence of Two GBS Antibodies in Women Previously Immunized With a GBS Vaccine

Start: Jan 2010Est. completion: Dec 201095 patients
Phase 1Completed
NCT00756067GSKPneumococcal vaccine GSK2189241A

Evaluation of Pneumococcal Vaccine Formulations in Elderly

Start: Sep 2008Est. completion: May 2009168 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

38 late-stage (Phase 3) programs, potential near-term approvals
Vaccine is the dominant modality (100% of programs)
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.