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Infections, Meningococcal

55
Pipeline Programs
3
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
21
0
29
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
58100%
+ 48 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
54 programs
1
1
21
26
3
MenACWYPhase 4
Mencevax ACWYPhase 4
Mencevax ACWYPhase 4
BexseroPhase 3
GSK Biologicals' Meningococcal vaccine GSK134612Phase 3Vaccine
+49 more programs
Pfizer
PfizerNEW YORK, NY
3 programs
3
Meningococcal vaccine GSK134612Phase 3Vaccine1 trial
Meningococcal vaccine GSK134612Phase 3Vaccine1 trial
Meningococcal vaccine GSK134612Phase 3Vaccine1 trial
Active Trials
NCT01962207Completed243Est. Jun 2018
NCT01939158Completed803Est. Dec 2019
NCT01934140Completed311Est. Aug 2018
GSK
GSKLONDON, United Kingdom
49 programs
4CMenBN/A1 trial
Posterior pharyngeal swabN/A1 trial
Investigational MenC-CRM adjuavnted with 12.5 ug of LHD153RPHASE_11 trial
Conjugated meningococcal ACWY-TTPHASE_21 trial
Conjugated meningococcal ACWY-TTPHASE_21 trial
+44 more programs
Active Trials
NCT02640677Completed2Est. Nov 2019
NCT01808365Completed1,000Est. Mar 2014
NCT02639351Completed80Est. Aug 2017
+46 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKMenACWY
GSKMencevax ACWY
GSKMencevax ACWY
GSKMeningococcal
GSKrMenB+OMV NZ
GSKMeningococcal group B Vaccine, rMenB+OMV NZ
PfizerMeningococcal vaccine GSK134612
PfizerMeningococcal vaccine GSK134612
PfizerMeningococcal vaccine GSK134612
GSKMeningococcal conjugate vaccine GSK134612
GSKMeningococcal vaccine GSK134612
GSKMeningococcal vaccine GSK134612
GSKMeningococcal vaccine GSK134612
GSKNimenrix
GSKMeningococcal vaccine GSK 134612

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 29,696 patients across 50 trials

Evaluation of Antibody Persistence Following 4 MenACWY Vaccinations

Start: Jul 2015Est. completion: Dec 2017128 patients
Phase 4Completed
NCT00290329GSKMencevax ACWY

Safety of Purified Meningococcal Vaccine With Serogroups ACWY, in 3,000 Filipino Subjects Aged > 2 Years

Start: Jan 2006Est. completion: Oct 2006249 patients
Phase 4Completed
NCT00227422GSKMencevax ACWY

Assess the Non-inferiority of GSK Biologicals' Mencevax™ ACWY (Manufactured by a New Process) vs Mencevax™ ACWY (the Already Existing Vaccine in the Market) When Given as a Single Dose to Subjects Aged 2-30 Yrs

Start: Jun 2005Est. completion: Nov 2005324 patients
Phase 4Completed
NCT02986854GSKMeningococcal

Study to Assess the Safety and Immunogenicity of a Single Dose of GlaxoSmithKline's (GSK) Meningococcal MenACWY-CRM Vaccine (Menveo), Administered to Subjects 15 Through 55 Years of Age, Approximately 4-6 Years After Primary ACWY Vaccination

Start: Dec 2016Est. completion: Dec 2017704 patients
Phase 3Completed
NCT02446743GSKrMenB+OMV NZ

Combined Study - Phase 3b MenB Long Term Persistence in Adolescents

Start: Nov 2015Est. completion: Sep 2016531 patients
Phase 3Completed
NCT02106390GSKMeningococcal group B Vaccine, rMenB+OMV NZ

Safety and Immunogenicity of GlaxoSmithKline Biologicals Meningococcal Group B Vaccine When Administered Concomitantly With GlaxoSmithKline Biologicals MenACWY Conjugate Vaccine to Healthy Infants

Start: Jun 2014Est. completion: Oct 2016750 patients
Phase 3Completed
NCT01934140PfizerMeningococcal vaccine GSK134612

Study to Evaluate the Long-term Antibody Persistence of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine (GSK134612) Versus Mencevax ACWY in Healthy Adolescents and Adults and Booster Response to MenACWY-TT Vaccine Administered at 10 Years Post-primary Vaccination

Start: Apr 2014Est. completion: Aug 2018311 patients
Phase 3Completed
NCT01939158PfizerMeningococcal vaccine GSK134612

Immunogenicity and Safety Study of 1 and 2 Doses of GlaxoSmithKline (GSK) Biologicals' Meningococcal Vaccine MenACWY-TT (GSK134612) in Toddlers, Persistence up to 5 Years After Vaccination and Co-administration With Pfizer's Prevenar 13™Vaccine

Start: Oct 2013Est. completion: Dec 2019803 patients
Phase 3Completed
NCT01962207PfizerMeningococcal vaccine GSK134612

The Long-term Antibody Persistence of MenACWY-TT Vaccine (PF-06866681) Versus Meningitec(Registered) or Mencevax(Registered) ACWY in Healthy Adolescents and Adults and a Booster Dose of MenACWY-TT Administered 10 Years Post Primary Vaccination

Start: Oct 2013Est. completion: Jun 2018243 patients
Phase 3Completed
NCT01777308GSKMeningococcal conjugate vaccine GSK134612

Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine Administered 6 Years Post-MenC Primary Vaccination in Healthy Subjects Who Were 12-18 Months at Primary Vaccination

Start: May 2013Est. completion: Apr 2016156 patients
Phase 3Completed
NCT01755689GSKMeningococcal vaccine GSK134612

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Meningococcal Vaccine With or Without Co-administration of Cervarix and Boostrix in Female Adolescents and Young Adults

Start: Jan 2013Est. completion: Apr 20141,300 patients
Phase 3Completed
NCT01767376GSKMeningococcal vaccine GSK134612

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Meningococcal Conjugate Vaccine (GSK134612) When Co-administered With Boostrix® in Subjects Between 11 and 25 Years of Age

Start: Jan 2013Est. completion: Jan 2014692 patients
Phase 3Completed
NCT01641042GSKMeningococcal vaccine GSK134612

Comparison of GlaxoSmithKline (GSK)134612 in Subjects With Increased Risk for Meningococcal Disease Versus Healthy Subjects

Start: Sep 2012Est. completion: Mar 201586 patients
Phase 3Completed

Persistence and Booster Study of GSK Biologicals' Meningococcal Vaccine (GSK134612) in Healthy Children

Start: Jan 2011Est. completion: May 2014271 patients
Phase 3Completed
NCT01235975GSKMeningococcal vaccine GSK 134612

Immunogenicity and Safety Study of GSK Biologicals' Meningococcal Vaccine Given as One Dose to Healthy Subjects Above 56 Years

Start: Nov 2010Est. completion: Aug 2011400 patients
Phase 3Completed
NCT01154088GSKMencevax ACWY

Immunogenicity and Safety of Meningococcal Vaccine GSK 134612 Versus Mencevax™ ACWY in Healthy 18-25 Year Olds

Start: Aug 2010Est. completion: Dec 20101,170 patients
Phase 3Completed
NCT01144663GSKNimenrix™

Immunogenicity and Safety of Meningococcal Vaccine GSK 134612 Co-administered With Pneumococcal and DTPa-HBV-IPV/Hib Vaccines

Start: Jul 2010Est. completion: Sep 20132,095 patients
Phase 3Completed
NCT00955682GSKMeningococcal vaccine GSK134612

Study to Evaluate Persistence of Antibodies After Vaccination With Meningococcal Vaccine GSK134612

Start: Aug 2009Est. completion: Sep 2012342 patients
Phase 3Completed
NCT00758264GSKMeningococcal vaccine GSK134612

Co-administration of Meningococcal Vaccine GSK134612 and Pneumococcal Vaccine GSK1024850A vs Individual Administration

Start: Oct 2008Est. completion: Nov 2009363 patients
Phase 3Completed
NCT00674583GSKGSK Biologicals' meningococcal vaccine GSK134612

Comparison of GSK Biologicals' Meningococcal Vaccine (GSK134612) and Licensed MenC-CRM197 Vaccine in Healthy Children

Start: May 2008Est. completion: Jan 2009414 patients
Phase 3Completed
NCT00614614GSKGSK Biologicals' Meningococcal vaccine GSK134612

Immuno,Safety of GSK Vaccine 134612 Given at Age of 12-15 Months 15-18 Months Post-priming With GSK Vaccine 792014

Start: Feb 2008Est. completion: Sep 20091,558 patients
Phase 3Completed

Non-Inferiority of Meningococcal Vaccine GSK134612 Versus Mencevax™ in 2-10 Year Old Subjects

Start: Sep 2007Est. completion: Jan 20091,504 patients
Phase 3Completed
NCT00508261GSKMeningococcal vaccine GSK134612

Co-Administration of Meningococcal Vaccine GSK134612 With Infanrix Hexa™ Versus Individual Administration of Each Vaccine

Start: Aug 2007Est. completion: Oct 2008793 patients
Phase 3Completed
NCT00474266GSKMeningococcal vaccine GSK134612

Safety & Immunogenicity Study of Meningococcal Vaccine GSK134612 Given With Priorix-Tetra™ to 12-23 Month-Old Children

Start: Jun 2007Est. completion: Mar 20081,000 patients
Phase 3Completed
NCT00464815GSKMeningococcal vaccine GSK134612

Non-Inferiority of Meningococcal Vaccine GSK134612 Versus Mencevax™ in 11-17 Year-Old Subjects

Start: May 2007Est. completion: Sep 20081,025 patients
Phase 3Completed

Primary Study to Demonstrate Non-inferiority and Immunogenicity of GSK Biologicals' Meningococcal Vaccine 134612

Start: Apr 2007Est. completion: Apr 2008611 patients
Phase 3Completed
NCT00453986GSKMeningococcal vaccine GSK134612

Lot Consistency, Immuno, Safety of Meningococcal Vaccine GSK134612 Given With Fluarix™ to 18-55 Year-Old Adults

Start: Apr 2007Est. completion: May 20081,352 patients
Phase 3Completed
NCT00317109GSKTritanrix™- HepB

Study to Asses DTPw-HBV/Hib at 15-18 Months (m) and Mencevax™ ACW at 24 to 30 m in Primed Subjects

Start: Apr 2006Est. completion: May 2007168 patients
Phase 3Completed
NCT00291343GSKTritanrix™- HepB

Immune Response & Safety of GSK Biologicals' Mencevax™ ACWY in Subjects Primed in the DTPW-HBV=HIB-MENAC-TT-011 Study

Start: Feb 2006Est. completion: Mar 2007296 patients
Phase 3Completed
NCT05082285GSKMenABCWY-2Gen low dose vaccine

A Study on the Safety, Tolerability and Immune Response of Meningococcal Combined ABCWY Vaccine in Healthy Infants

Start: Nov 2021Est. completion: Mar 2025724 patients
Phase 2Completed
NCT03652610GSKMenACWY liquid vaccine with approximately 30% MenA FS

A Study to Investigate the Safety and Immunogenicity of Different Formulations of GSK Biologicals' Meningococcal ACWY Conjugate Vaccine (GSK3536820A and Menveo) Administered to Healthy Adults 18 to 40 Years of Age

Start: Sep 2018Est. completion: Jun 2019996 patients
Phase 2Completed
NCT02946385GSKMeningococcal ABCWY Vaccine

Study to Assess the Immunological Long-term Persistence of Antibodies (Abs) 2 Years After GlaxoSmithKline (GSK) Meningococcal ABCWY Vaccination in the V102_15 (NCT02212457) and Response to a Booster in Adolescents

Start: Nov 2016Est. completion: Feb 2018604 patients
Phase 2Completed
NCT01165242GSKMeningococcal vaccine GSK 134612

Immunogenicity and Safety Study of GSK Biologicals' Meningococcal Vaccine GSK 134612 Versus Menactra® in Healthy Adolescents/Adults

Start: Aug 2010Est. completion: Jul 20111,013 patients
Phase 2Completed
NCT00718666GSKMeningococcal vaccine GSK134612

The Long-term Antibody Persistence of GSK Biologicals' Meningococcal Vaccine GSK134612 in Healthy Toddlers

Start: Oct 2008Est. completion: Mar 2014387 patients
Phase 2Completed

The Long-term Antibody Persistence of GSK Biologicals' Meningococcal Vaccine GSK134612 in Healthy Adolescents/Adults

Start: Jul 2008Est. completion: Oct 2013818 patients
Phase 2Completed
NCT00661557GSKMeningococcal vaccine GSK134612

Comparison of GSK134612 in Subjects Previously Vaccinated Against Meningococcal Disease Versus Non-vaccinated Subjects

Start: May 2008Est. completion: Dec 2008271 patients
Phase 2Completed
NCT00471081GSKMeningococcal vaccine GSK134612

Immunogenicity and Safety of Meningococcal Vaccine GSK134612 Given as 1 or 2 Doses to Healthy 9-12 Months Old Toddlers.

Start: Jul 2007Est. completion: Nov 2008385 patients
Phase 2Completed
NCT00454909GSKMeningococcal vaccine 134612

Immunogenicity and Safety of Meningococcal Vaccine GSK134612 vs. Menactra® in Healthy Adolescent/Adults Aged 10-25 Years.

Start: Apr 2007Est. completion: Apr 2008873 patients
Phase 2Completed
NCT00427908GSKGSK Biolgicals' meningococcal vaccine 134612

Study in Children to Evaluate Non-Inferiority and Persistence up to 5 Years of GSK Bio Meningococcal Vaccine 134612

Start: Feb 2007Est. completion: Dec 2007613 patients
Phase 2Completed
NCT00390143GSKMeningococcal vaccine 134612

Study in Adolescents/Adults to Evaluate the Persistence up to 3.5 Yrs of GSK Biologicals Meningococcal Vaccine 134612

Start: Feb 2007Est. completion: May 200946 patients
Phase 2Completed
NCT00356369GSKmeningococcal ACWY

Study in Adolescents/Adults to Evaluate Non-inferiority&Persistence up to 5 Years of GSK Bio MenACWY Conjugate Vaccine

Start: Dec 2006Est. completion: Feb 2008500 patients
Phase 2Completed
NCT00126945GSKMeningococcal Vaccine

Evaluate 4 Different Formulations of Meningococcal Serogroups A,C,W-135,Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 15-19 Yrs

Start: Aug 2005Est. completion: Oct 2005125 patients
Phase 2Completed
NCT00126984GSKConjugated meningococcal ACWY-TT

Study in Children to Evaluate the Immunogenicity and Safety of 4 Formulations of GSK Bio MenACWY-TT Conjugate Vaccine

Start: Jul 2005Est. completion: Feb 2008508 patients
Phase 2Completed
NCT00196976GSKConjugated meningococcal ACWY-TT

Safety & Immunogenicity of 1 Dose of GSK134612 in Children 12-14 Months and 3-5 Years Old

Start: Mar 2005Est. completion: Mar 2006461 patients
Phase 2Completed
NCT00196963GSKMeningococcal

Evaluate 4 Different Formulations of Meningococcal Serogroups A, C, W-135, Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 15-19 Yrs

Start: Mar 2005Est. completion: Jul 2005125 patients
Phase 2Completed
NCT00196950GSKMeningococcal

Study to Evaluate Meningococcal Serogroups A,C,W-135,Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 18-25 Years

Start: Sep 2003Est. completion: Oct 200350 patients
Phase 2Completed

Study to Evaluate GlaxoSmithKline (GSK) Biologicals' MenC-TT and Hib-MenC-TT or Meningitec™ in Healthy Toddlers

Start: Jan 2003Est. completion: Jul 2003500 patients
Phase 2Completed
NCT00137917GSKMeningococcal serogroup B vaccine

Immunogenicity & Safety Study of a Meningococcal Serogroup B Vaccine Given in a 3 Dose Schedule to Healthy Adolescents Aged 12-18 Yrs

Start: Jul 2002Est. completion: Jun 2003478 patients
Phase 2Completed

Study to Evaluate GlaxoSmithKline (GSK) Biologicals' MenC-TT Vaccine and Hib-MenC-TT Vaccine in Infants

Start: Mar 2002Est. completion: Jan 2003500 patients
Phase 2Completed
NCT02639351GSKInvestigational MenC-CRM adjuavnted with 12.5 ug of LHD153R

Safety and Immunogenicity of an Aluminium Hydroxide/LHD153R Adjuvanted Meningococcal C-CRM197 Conjugate Vaccine

Start: Mar 2016Est. completion: Aug 201780 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

29 late-stage (Phase 3) programs, potential near-term approvals
Vaccine is the dominant modality (100% of programs)
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.