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Indolent Systemic Mastocytosis

0
Pipeline Programs
2
Companies
4
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
375%
Monoclonal Antibody
125%

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Blueprint Medicines
Blueprint MedicinesMA - Cambridge
3 programs
AvapritinibN/ASmall Molecule1 trial
AvapritinibPHASE_2Small Molecule1 trial
ElenestinibPHASE_2_3Small Molecule1 trial
Active Trials
NCT07255638Recruiting80Est. Dec 2028
NCT03731260Active Not Recruiting251Est. Jun 2027
NCT04910685Recruiting534Est. Sep 2032
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
sarilumabPHASE_2Monoclonal Antibody1 trial
Active Trials
NCT03770273Completed21Est. Jul 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Blueprint MedicinesElenestinib
Allergy Therapeuticssarilumab
Blueprint MedicinesAvapritinib
Blueprint MedicinesAvapritinib

Clinical Trials (4)

Total enrollment: 886 patients across 4 trials

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

Start: Nov 2021Est. completion: Sep 2032534 patients
Phase 2/3Recruiting

Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis

Start: Jun 2019Est. completion: Jul 202321 patients
Phase 2Completed

(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis

Start: Apr 2019Est. completion: Jun 2027251 patients
Phase 2Active Not Recruiting

A Non-Interventional Study in Participants With Indolent Systemic Mastocytosis (ISM) in Germany

Start: Dec 2025Est. completion: Dec 202880 patients
N/ARecruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 886 patients
Small Molecule is the dominant modality (75% of programs)
2 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.