Impaired Glucose Tolerance

7
Pipeline Programs
4
Companies
4
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
3
4
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 3 programs with unclassified modality

On Market (4)

Approved therapies currently available

Takeda
ACTOSApproved
pioglitazone
Takeda
oral1999
Pfizer
ALTACEApproved
ramipril
Pfizer
oral1991
U
PIOGLITAZONE HYDROCHLORIDEApproved
pioglitazone
Unknown Company
oral2013
U
VOSTALLYApproved
ramipril
Unknown Company
Angiotensin Converting Enzyme Inhibitor [EPC]oral2025

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Takeda
TakedaTOKYO, Japan
2 programs
1
1
PioglitazonePhase 31 trial
VogliboseN/A1 trial
Active Trials
NCT01993927Completed742Est. Aug 2013
NCT00220961Completed602Est. Apr 2010
Pfizer
PfizerNEW YORK, NY
1 program
1
1
RamiprilPhase 3Small Molecule
GSK
GSKLONDON, United Kingdom
1 program
1
RamiprilPhase 3Small Molecule1 trial
Active Trials
NCT00095654Completed5,000Est. Oct 2006
DS
Daiichi SankyoChina - Shanghai
1 program
AspirinN/A1 trial
Active Trials
NCT00122447Completed84Est. May 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
TakedaPioglitazone
GSKRamipril
TakedaVoglibose
Daiichi SankyoAspirin

Clinical Trials (4)

Total enrollment: 6,428 patients across 4 trials

NCT00220961TakedaPioglitazone

Actos Now for Prevention of Diabetes (ACT NOW)

Start: Jan 2004Est. completion: Apr 2010602 patients
Phase 3Completed

The DREAM (Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication) Trial

Start: Jul 2001Est. completion: Oct 20065,000 patients
Phase 3Completed

Voglibose Tablets 0.2 / OD Tablets 0.2 Special Drug Use Surveillance "Long-term Use in Patients With Impaired Glucose Tolerance"

Start: Nov 2009Est. completion: Aug 2013742 patients
N/ACompleted

Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance

Start: May 2005Est. completion: May 201184 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space