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Idiopathic Short Stature

7
Pipeline Programs
11
Companies
13
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
5
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Genentech
GenentechCA - Oceanside
1 program
1
Aromatase InhibitorPhase 3
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
Aromatase InhibitorPhase 3
Sandoz
SandozAustria - Kundl
1 program
1
Aromatase InhibitorPhase 31 trial
Active Trials
NCT01248416Completed76Est. Sep 2016
Dong-A ST
Dong-A STKorea - Seoul
1 program
1
DA-3002Phase 31 trial
Active Trials
NCT01786902Completed70Est. Apr 2014
Pfizer
PfizerNEW YORK, NY
1 program
1
GenotropinPhase 31 trial
Active Trials
NCT00396097Completed316Est. Aug 2012
Amoytop Biotech
Amoytop BiotechChina - Xiamen
2 programs
2
YPEG-rhGHPhase 21 trial
somatropinPhase 25 trials
Active Trials
NCT05838885Completed78Est. Dec 2023
NCT07551804Not Yet Recruiting36Est. Jun 2028
NCT07309562Recruiting141Est. May 2028
+3 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
No treatment is givenN/A1 trial
Active Trials
NCT05894876Terminated43Est. Mar 2025
BioMarin Pharmaceutical
1 program
Vosoritide InjectionPHASE_21 trial
Active Trials
NCT06382155Recruiting100Est. Dec 2036
Novartis
NovartisBASEL, Switzerland
1 program
Aromatase InhibitorPHASE_3
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Saizen®PHASE_31 trial
Active Trials
NCT01746862Completed90Est. Mar 2015
Ipsen
IpsenChina - Tianjin
1 program
Nutropin [SomatropinPHASE_41 trial
Active Trials
NCT01438801Withdrawn0Est. May 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
IpsenNutropin [Somatropin
Amoytop Biotechsomatropin
Amoytop Biotechsomatropin
Merck & Co.Saizen®
Dong-A STDA-3002
SandozAromatase Inhibitor
PfizerGenotropin
Amoytop Biotechsomatropin
Amoytop Biotechsomatropin
BioMarin PharmaceuticalVosoritide Injection
Amoytop BiotechYPEG-rhGH
Amoytop Biotechsomatropin
Novo NordiskNo treatment is given

Clinical Trials (13)

Total enrollment: 1,720 patients across 13 trials

NCT01438801IpsenNutropin [Somatropin

Predictive Value of the Insulin-like Growth Factor-1 (IGF-1) Generation Test for the Growth Response to Growth Hormone Treatment (PRED-IGF)

Start: May 2013Est. completion: May 20130
Phase 4Withdrawn

The Efficacy and Safety of Inpegsomatropin Injection in Children With Short Stature Born Small for Gestational Age

Start: Jan 2026Est. completion: May 2028141 patients
Phase 3Recruiting

The Efficacy and Safety of Inpegsomatropin Injection in Children With Idiopathic Short Stature

Start: Apr 2025Est. completion: Jun 2028300 patients
Phase 3Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of Saizen® in Children With Idiopathic Short Stature (ISS)

Start: Dec 2012Est. completion: Mar 201590 patients
Phase 3Completed

Efficacy and Safety of DA-3002 in Children With Idiopathic Short Stature

Start: Feb 2012Est. completion: Apr 201470 patients
Phase 3Completed
NCT01248416SandozAromatase Inhibitor

Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature

Start: Nov 2010Est. completion: Sep 201676 patients
Phase 3Completed

Individualized, Target-Driven Treatment Of Children With Idiopathic Short Stature

Start: Dec 2006Est. completion: Aug 2012316 patients
Phase 3Completed

Safety and Efficacy of Y-shape Pegylated Somatropin in Growth Hormone Deficiency Children

Start: Dec 2018Est. completion: Jul 2023434 patients
Phase 2/3Completed

Safety, Pharmacokinetic (PK) Profile and Efficacy of Inpegsomatropin Injection in Adults With Growth Hormone Deficiency

Start: May 2026Est. completion: Jun 202836 patients
Phase 2Not Yet Recruiting

A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature

Start: Oct 2024Est. completion: Dec 2036100 patients
Phase 2Recruiting

A Trial of YPEG-rhGH in Children With Short Stature

Start: Feb 2022Est. completion: Dec 202378 patients
Phase 2Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Pegylated-Somatropin in Healthy Volunteers

Start: Jan 2011Est. completion: Aug 201236 patients
Phase 1Completed
NCT05894876Novo NordiskNo treatment is given

A Study of the Genetic Basis of Response to Growth Hormone Treatment in Children With Idiopathic Short Stature

Start: Apr 2024Est. completion: Mar 202543 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 1,720 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.