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Hypotension

2
Pipeline Programs
8
Companies
14
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
Plasmalyte 3ml/kg/hr groupPhase 41 trial
Active Trials
NCT02135146Completed40Est. Sep 2016
Advanced Solutions Life Sciences
1 program
1
Impedance Threshold DevicePhase 21 trial
Active Trials
NCT00256724Completed47Est. Jan 2008
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
3 programs
Automated adjustment of vasopressorN/A1 trial
Nudge to reduce intraoperative hypotensionN/A1 trial
closed-loop systemN/A1 trial
Active Trials
NCT04639037Completed53Est. Jan 2022
NCT04062994Completed30,000Est. Oct 2019
NCT04089644Completed30Est. Mar 2020
Eppendorf
EppendorfGermany - Hamburg
3 programs
EEG-guided general anesthesiaN/A1 trial
MonitoringN/A1 trial
Oscillometric blood pressure monitoring at 2.5-minute intervalsN/A1 trial
Active Trials
NCT05293288Completed110Est. Aug 2023
NCT05842759Completed120Est. Aug 2023
NCT06314074Completed264Est. Oct 2024
Edwards Lifesciences
3 programs
EV1000A Clinical Platform with Acumen Hypotension Prediction Index Feature SoftwareN/A1 trial
HPI based hemodynamic optimization algorithmN/A1 trial
Hypotension probability indexN/A1 trial
Active Trials
NCT03805217Completed485Est. Mar 2020
NCT04149314Completed142Est. Oct 2023
NCT04151264Completed75Est. Dec 2024
B. Braun
B. BraunGermany - Melsungen
1 program
BioLogic RRN/A1 trial
Active Trials
NCT01749761Completed25Est. Dec 2013
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
fluid challengeN/A1 trial
Active Trials
NCT01941472Completed40Est. Dec 2015
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
1 program
HES 130/0.4PHASE_41 trial
Active Trials
NCT00694343Completed167Est. Jun 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Colorado TherapeuticsPlasmalyte 3ml/kg/hr group
Fresenius KabiHES 130/0.4
Advanced Solutions Life SciencesImpedance Threshold Device
EppendorfOscillometric blood pressure monitoring at 2.5-minute intervals
EppendorfMonitoring
EppendorfEEG-guided general anesthesia
Angeles TherapeuticsAutomated adjustment of vasopressor
Edwards LifesciencesHypotension probability index
Edwards LifesciencesHPI based hemodynamic optimization algorithm
Angeles Therapeuticsclosed-loop system
Edwards LifesciencesEV1000A Clinical Platform with Acumen Hypotension Prediction Index Feature Software
Angeles TherapeuticsNudge to reduce intraoperative hypotension
UNION therapeuticsfluid challenge
B. BraunBioLogic RR

Clinical Trials (14)

Total enrollment: 31,598 patients across 14 trials

NCT02135146Colorado TherapeuticsPlasmalyte 3ml/kg/hr group

Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach

Start: Jan 2014Est. completion: Sep 201640 patients
Phase 4Completed
NCT00694343Fresenius KabiHES 130/0.4

Efficacy of Voluven® for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section

Start: Jun 2008Est. completion: Jun 2010167 patients
Phase 4Completed
NCT00256724Advanced Solutions Life SciencesImpedance Threshold Device

Efficacy Study of a Facemask Device to Treat Hypotension

Start: Jun 2005Est. completion: Jan 200847 patients
Phase 2Completed
NCT06314074EppendorfOscillometric blood pressure monitoring at 2.5-minute intervals

2.5 Versus 5 Minutes Trial

Start: Mar 2024Est. completion: Oct 2024264 patients
N/ACompleted
NCT05842759EppendorfMonitoring

Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study

Start: Mar 2023Est. completion: Aug 2023120 patients
N/ACompleted
NCT05293288EppendorfEEG-guided general anesthesia

Effect of EEG-guided General Anesthesia on Cumulative Dose of Norepinephrine

Start: Feb 2022Est. completion: Aug 2023110 patients
N/ACompleted
NCT04639037Angeles TherapeuticsAutomated adjustment of vasopressor

Control Mean Arterial Pressure in the Intensive Care Unit

Start: Jan 2021Est. completion: Jan 202253 patients
N/ACompleted
NCT04151264Edwards LifesciencesHypotension probability index

Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery

Start: May 2020Est. completion: Dec 202475 patients
N/ACompleted
NCT04149314Edwards LifesciencesHPI based hemodynamic optimization algorithm

The "Hypotension Prediction Index" in Patients Undergoing Lung Surgery

Start: Nov 2019Est. completion: Oct 2023142 patients
N/ACompleted
NCT04089644Angeles Therapeuticsclosed-loop system

Manual vs Closed-loop Control of Mean Arterial Pressure

Start: Sep 2019Est. completion: Mar 202030 patients
N/ACompleted
NCT03805217Edwards LifesciencesEV1000A Clinical Platform with Acumen Hypotension Prediction Index Feature Software

Hypotension Prediction Index Study (HPI Study)

Start: May 2019Est. completion: Mar 2020485 patients
N/ACompleted
NCT04062994Angeles TherapeuticsNudge to reduce intraoperative hypotension

A Clinical Decision Support Trial to Reduce Intraoperative Hypotension

Start: Sep 2018Est. completion: Oct 201930,000 patients
N/ACompleted
NCT01941472UNION therapeuticsfluid challenge

Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness

Start: Sep 2013Est. completion: Dec 201540 patients
N/ACompleted
NCT01749761B. BraunBioLogic RR

Blood Pressure Guided Biofeedback on Hemodialysis and the Reduction of IntraDialytic Hypotension

Start: Jan 2013Est. completion: Dec 201325 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.