Hyperlipidemias

4
Pipeline Programs
5
Companies
50
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
150%
Small Molecule
150%
+ 4 programs with unclassified modality

On Market (1)

Approved therapies currently available

Amgen
REPATHAApproved
evolocumab
Amgen
PCSK9 Inhibitor [EPC]injection2015

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
EvolocumabPhase 4Monoclonal Antibody1 trial
Active Trials
NCT04608474Unknown120Est. Dec 2024
Pfizer
PfizerNEW YORK, NY
1 program
1
atorvastatinPhase 4Small Molecule5 trials
Active Trials
NCT01053065Completed60
NCT06567327Completed82Est. Apr 2025
NCT05093205Completed35Est. Jul 2022
+2 more trials
Silence Therapeutics
Silence TherapeuticsGermany - Berlin
1 program
1
SLN360Phase 11 trial
Active Trials
NCT04606602CompletedEst. Aug 2023
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
2 programs
Percentage of Secondary Prevention Patients Treated to Their LDL-C TargetsN/A1 trial
Percentage of Secondary Prevention Patients Treated to Their LDL-C TargetsN/A1 trial
Active Trials
NCT00536965Completed951Est. Dec 2007
NCT00536796Completed1,096Est. Dec 2007
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
TeleMOVE!N/A1 trial
Active Trials
NCT03330548CompletedEst. Mar 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AmgenEvolocumab
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin
Pfizeratorvastatin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 55,513 patients across 50 trials

Lipid Management in Renal Transplant Recipients Using Evolocumab.

Start: Feb 2021Est. completion: Dec 2024120 patients
Phase 4Unknown
NCT02125682Pfizeratorvastatin

The HDL Particle Protection Study

Start: Jan 2012Est. completion: May 201716 patients
Phase 4Completed
NCT01033058Pfizeratorvastatin

Intensive Statin Treatment for STEMI Patients Undergoing Primary PCI

Start: Dec 2009Est. completion: Jun 2011500 patients
Phase 4Unknown
NCT01239849Pfizeratorvastatin

Korean AMADEUS Study

Start: Feb 2009Est. completion: Feb 2011500 patients
Phase 4Unknown
NCT00728988Pfizeratorvastatin

Atorvastatin Pre-Treatment Study In Asian Patients With Acute Coronary Syndrome

Start: Sep 2008Est. completion: Apr 2010499 patients
Phase 4Completed
NCT00772564Pfizeratorvastatin

The Use of Statins for Myocardial Death Prevention

Start: Aug 2008Est. completion: Aug 201025 patients
Phase 4Completed
NCT00917644Pfizeratorvastatin

Bioequivalence Study Comparing A New 80 Mg Atorvastatin Tablet To A 80 Mg Atorvastatin Commercial Tablet

Start: Jul 2008Est. completion: Sep 200876 patients
Phase 4Completed
NCT00917579Pfizeratorvastatin

Bioequivalence Study Comparing A New 10 Mg Atorvastatin Tablet To A 10 Mg Atorvastatin Commercial Tablet

Start: Jul 2008Est. completion: Sep 200876 patients
Phase 4Completed
NCT00844376Pfizeratorvastatin

Bioavailability Study for New Atorvastatin Formulation

Start: Feb 2008Est. completion: Mar 200812 patients
Phase 4Completed
NCT01200056Pfizeratorvastatin

Virtual Histology Findings and Effects of Varying Doses of Atorvastatin Treatment

Start: Aug 2007Est. completion: Jun 201040 patients
Phase 4Completed
NCT00701220Pfizeratorvastatin

Statin Therapy for Ischemic and Nonischemic Cardiomyopathy

Start: Apr 2007Est. completion: Dec 20109 patients
Phase 4Completed
NCT00407537Pfizeratorvastatin

Caduet vs Usual Care in Subjects With Hypertension and Additional Risk Factors

Start: Mar 2007Est. completion: Oct 20091,531 patients
Phase 4Completed
NCT00412113Pfizeratorvastatin

A Multi-Risk Factor Strategy vs a Guideline-Based Approach in Achieving Blood Pressure and Lipid Goals in Hypertensives at Extra Risk

Start: Jan 2007Est. completion: Apr 2008245 patients
Phase 4Completed
NCT00640744Pfizeratorvastatin

Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions

Start: Feb 2006Est. completion: Feb 201012 patients
Phase 4Unknown
NCT00449410Pfizeratorvastatin

Silent Cerebrovascular Lesion and Cognitive Decline Prevention by Cholesterol Lowering in Elderly AF Patients

Start: May 2005Est. completion: Oct 200635 patients
Phase 4Completed
NCT00141232Pfizeratorvastatin

Evaluating Atorvastatin With Omega-3 Fatty Acids in Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

Start: Nov 2004Est. completion: Jul 2006810 patients
Phase 4Completed
NCT00150384Pfizeratorvastatin

Clinical Utility of Caduet in Achieving Blood Pressure and Lipid Endpoints in a Specific Patient Population

Start: Jul 2004Est. completion: Aug 2005500 patients
Phase 4Completed
NCT00645151Pfizeratorvastatin

A Study Of The Efficacy Of Atorvastatin In Lowering Cholesterol In Latin American Patients With High Cholesterol

Start: Apr 2004Est. completion: Feb 2005512 patients
Phase 4Completed
NCT00141141Pfizeratorvastatin

Efficacy And Safety Study Of Atorvastatin Versus Simvastatin In Type 2 Diabetic Subjects With Hypercholesterolemia

Start: Jan 2004Est. completion: Apr 2007383 patients
Phase 4Completed
NCT00645424Pfizeratorvastatin

A Study To Evaluate The Safety And Efficacy Of Atorvastatin In Patients With Diabetes And High Cholesterol

Start: Dec 2003Est. completion: Oct 2004155 patients
Phase 4Completed
NCT00647543Pfizeratorvastatin

Atorvastatin Study For The Treatment Of High Cholesterol In Patients From Thailand

Start: Aug 2003Est. completion: Apr 2004242 patients
Phase 4Completed
NCT00163150Pfizeratorvastatin

Vasomotor Reactivity In Cerebral Small Vessel Disease And New Approach To Treat Lacunar Stroke

Start: Jun 2003Est. completion: Feb 2006128 patients
Phase 4Completed
NCT00644670Pfizeratorvastatin

A Study Of The Efficacy Of Atorvastatin For Lowering Cholesterol In High-Risk Patients With High Cholesterol

Start: Jun 2003Est. completion: Mar 2004232 patients
Phase 4Completed
NCT00442845Pfizeratorvastatin

Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)

Start: Jan 2003Est. completion: Feb 20042,080 patients
Phase 4Completed
NCT00442325Pfizeratorvastatin

Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets

Start: Jan 2003Est. completion: Feb 2004595 patients
Phase 4Completed
NCT00163202Pfizeratorvastatin

Comparative Atorvastatin Pleiotropic Effects

Start: Jun 2002Est. completion: Aug 2005330 patients
Phase 4Completed
NCT00159718Pfizeratorvastatin

Double Blind Atorvastatin Amlodipine Study

Start: Jul 2001Est. completion: Jan 2007360 patients
Phase 4Completed
NCT00124397Pfizeratorvastatin

Atorvastatin and Endothelial Function in Type 2 Diabetes Mellitus (ATTEND-Study)

Start: Jul 2001Est. completion: Dec 2004186 patients
Phase 4Completed
NCT00590135Pfizeratorvastatin

The Effect of Lipitor on Aortic Stenosis

Start: Aug 2000Est. completion: Apr 201059 patients
Phase 4Terminated
NCT00457340Pfizeratorvastatin

Atorvastatin For The Reduction Of Ventricular Arrhythmias

Start: Feb 2000Est. completion: Sep 2004220 patients
Phase 4Completed
NCT00380939Pfizeratorvastatin

This Study Uses Ultrasound to Determine Whether Atorvastatin or Pravastatin Effects the Progression of Coronary Plaque.

Start: Apr 1999Est. completion: Dec 2000600 patients
Phase 4Completed
NCT00159835Pfizeratorvastatin

Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD

Start: Feb 1999Est. completion: Mar 20058,600 patients
Phase 4Completed
NCT00327691Pfizeratorvastatin

A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels

Start: Apr 1998Est. completion: Aug 20048,600 patients
Phase 4Completed
NCT00327418Pfizeratorvastatin

CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events

Start: Jan 1997Est. completion: Feb 20042,800 patients
Phase 4Completed
NCT00827606Pfizeratorvastatin

Atorvastatin Three Year Pediatric Study

Start: Mar 2009Est. completion: Oct 2013272 patients
Phase 3Completed
NCT00343655Pfizeratorvastatin

Evaluation of Atorvastatin Treatment on Carotid Plaque.

Start: Jan 2007Est. completion: Aug 2007160 patients
Phase 3Terminated
NCT00267267Pfizeratorvastatin

A Clinical Trial Comparing Torcetrapib/Atorvastatin to Ezetimibe/Simvastatin In Subjects With A Cholesterol Disorder.

Start: Jan 2006Est. completion: Jan 20071,784 patients
Phase 3Terminated
NCT00136942Pfizeratorvastatin

A Swiss Study With Atorvastatin in Hyperlipidemic Patients Measuring LDL-Cholesterol

Start: Apr 2005370 patients
Phase 3Completed
NCT00134485Pfizeratorvastatin

Study To Evaluate The Safety And Efficacy Of Torcetrapib/Atorvastatin In Subjects With Familial Hypercholerolemia

Start: Mar 2005Est. completion: Mar 2006400 patients
Phase 3Completed
NCT00145431Pfizeratorvastatin

Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Subjects With A Genetic Cholesterol Disorder.

Start: Mar 2005Est. completion: Dec 200641 patients
Phase 3Terminated
NCT00134511Pfizeratorvastatin

Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Patients With Genetic High Cholesterol Disorder

Start: Mar 2005Est. completion: Nov 200530 patients
Phase 3Completed
NCT00134498Pfizeratorvastatin

A Study Comparing The Efficacy & Safety Of Torcetrapib/Atorvastatin And Atorvastatin In Subjects With High Triglycerides

Start: Feb 2005Est. completion: Nov 2006160 patients
Phase 3Completed
NCT00137462Pfizeratorvastatin

Lipitor Trial To Study The Effect Of Torcetrpib/Atorvastatin To Atorvastatin Alone.

Start: Nov 2004Est. completion: Sep 2006900 patients
Phase 3Completed
NCT00134264Pfizeratorvastatin

A Study Examining Torcetrapib/Atorvastatin And Atorvastatin Effects On Clinical CV Events In Patients With Heart Disease

Start: Jul 2004Est. completion: Jun 200715,067 patients
Phase 3Terminated
NCT00150371Pfizeratorvastatin

Canadians Achieve Cholesterol Targets Fast With Atorvastatin Stratified Titration

Start: Jun 2004Est. completion: May 20051,100 patients
Phase 3Completed
NCT00143234Pfizeratorvastatin

Amlodipine/Atorvastatin Combination to Reduce the Health Risk of High Blood Pressure and High Cholesterol Levels

Start: May 2004Est. completion: Jul 20051,825 patients
Phase 3Completed
NCT01768481Pfizeratorvastatin

Intima Media Thickness Regression in Dyslipidemic Teenagers

Start: Jan 2004Est. completion: Jun 201016 patients
Phase 3Completed
NCT00136981Pfizeratorvastatin

Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.

Start: Dec 2003Est. completion: Nov 2006800 patients
Phase 3Completed
NCT00134173Pfizeratorvastatin

A Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease

Start: Oct 2003Est. completion: Sep 20061,100 patients
Phase 3Completed
NCT00163163Pfizeratorvastatin

Carotid Atorvastatin Study in Hyperlipidemic Post-Menopausal Women

Start: Jan 2003Est. completion: Jul 2006400 patients
Phase 3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 companies competing in this space