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Hyperlipidemia

30
Pipeline Programs
30
Companies
31
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
0
2
2
12
8
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
643%
Peptide
321%
Monoclonal Antibody
321%
RNA Therapeutic
214%
+ 28 programs with unclassified modality

Competitive Landscape

27 companies ranked by most advanced pipeline stage

MSD
MSDIreland - Ballydine
4 programs
1
1
2
Self Monitoring Lipid AnalyzerPhase 41 trial
simvastatinPhase 4Small Molecule1 trial
EnlicitidePhase 3Peptide1 trial
simvastatin 20 mg/ezetimibePhase 2/31 trial
Active Trials
NCT00566267Completed58Est. Nov 2007
NCT07216482Recruiting975Est. Mar 2027
NCT01212159Completed70Est. Aug 2015
+1 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
4 programs
1
1
2
Self Monitoring Lipid AnalyzerPhase 4
simvastatinPhase 4Small Molecule
EnlicitidePhase 3Peptide
simvastatin 20 mg/ezetimibePhase 2/3
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
1
Minute Maid Heart Wise orange juicePhase 41 trial
Algorithm- and multi-professional team-supported lipid managementN/A1 trial
Active Trials
NCT07334834Recruiting100Est. Jul 2027
NCT00249938Completed60Est. Aug 2006
Dong-A ST
Dong-A STKorea - Seoul
1 program
1
RosuvastatinPhase 4Small Molecule1 trial
Active Trials
NCT02280590Completed223
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
1 program
1
Self Monitoring Lipid AnalyzerPhase 4
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
SimvastatinPhase 4Small Molecule1 trial
Active Trials
NCT00451828Completed1,000
Pfizer
PfizerNEW YORK, NY
4 programs
3
BococizumabPhase 3Monoclonal Antibody1 trial
BococizumabPhase 3Monoclonal Antibody1 trial
BococizumabPhase 3Monoclonal Antibody1 trial
Lipid Self TestN/A1 trial
Active Trials
NCT00828945Completed259Est. Mar 2011
NCT01968954Completed711Est. Apr 2016
NCT01968967Completed2,139Est. Jul 2017
+1 more trials
Prevail Therapeutics
3 programs
1
1
EvacetrapibPhase 3
LY3015014 IVPhase 1
exenatideN/APeptide
Abbott
AbbottABBOTT PARK, IL
2 programs
2
Niacin ER/Simvastatin TabletsPhase 31 trial
fenofibratePhase 31 trial
Active Trials
NCT00465088Completed199
NCT00195793Completed174
Chong Kun Dang Pharmaceutical
1
Atorvastatin10mg, Ezetimibe10mgPhase 31 trial
Active Trials
NCT02451098Completed385Est. Jan 2016
Genovate Biotechnology
Genovate BiotechnologyTaiwan - Hsinchu
1 program
1
NidaddPhase 31 trial
Active Trials
NCT00244231Completed70Est. Aug 2005
Otsuka
OtsukaJapan - Tokushima
1 program
1
ProbucolPhase 31 trial
Active Trials
NCT01349010Completed264Est. Feb 2013
Hanmi Pharmaceutical
1 program
1
Simvastatin CRPhase 31 trial
Active Trials
NCT00973115Completed132Est. Aug 2009
Response Pharmaceuticals
Response PharmaceuticalsVA - Falls Church
1 program
1
SLx-4090Phase 21 trial
Active Trials
NCT00810979Completed133Est. Sep 2009
Viking Therapeutics
Viking TherapeuticsCA - San Diego
1 program
1
VK2809Phase 21 trial
Active Trials
NCT02927184Completed59Est. Mar 2019
JW Pharmaceutical
JW PharmaceuticalKorea - Seoul
2 programs
2
Livalo fixed combination drugPhase 11 trial
Pitavastatin, ValsartanPhase 1Small Molecule1 trial
Active Trials
NCT01764178Completed52Est. Dec 2013
NCT01406431Completed48Est. Oct 2012
Sandoz
SandozAustria - Kundl
1 program
1
100 mg inclisiran sodiumPhase 1RNA Therapeutic
Jeil Pharmaceutical
Jeil PharmaceuticalKorea - Seoul
1 program
1
MetforminPhase 11 trial
Active Trials
NCT02186483Completed24Est. Feb 2015
Kowa Pharmaceuticals
Kowa PharmaceuticalsAL - Montgomery
1 program
1
PitavastatinPhase 1Small Molecule1 trial
Active Trials
NCT01695954Completed34Est. Jan 2013
Takeda
TakedaTOKYO, Japan
2 programs
TAK-085PHASE_41 trial
TAK-085PHASE_41 trial
Active Trials
NCT02839902Completed53Est. Aug 2017
NCT02824432Completed37Est. Aug 2017
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
Awareness of Chinese National Adult Lipid Treatment Guideline (2007) and Rate of Patients Achieving N/A1 trial
Active Trials
NCT00781560Completed2,575Est. Jul 2009
Medica Corp
Medica CorpMA - Bedford
1 program
Glucose and lipidsN/A1 trial
Active Trials
NCT02029989Completed121Est. Feb 2012
Oregon Therapeutics
PlasmapharesisN/A1 trial
Active Trials
NCT02388633Completed8Est. Jul 2018
Lundbeck
LundbeckDenmark - Copenhagen
1 program
first phase insulin secretionN/A1 trial
Active Trials
NCT01571609Completed40Est. Nov 2014
Novartis
NovartisBASEL, Switzerland
1 program
100 mg inclisiran sodiumPHASE_1RNA Therapeutic1 trial
Active Trials
NCT04774003Completed40Est. Oct 2021
Daiichi Sankyo
Daiichi SankyoChina - Shanghai
1 program
Minute Maid Heart Wise orange juicePHASE_4
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Self Monitoring Lipid AnalyzerPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
TakedaTAK-085
TakedaTAK-085
Dong-A STRosuvastatin
MSDSelf Monitoring Lipid Analyzer
MSDsimvastatin
Colorado TherapeuticsMinute Maid Heart Wise orange juice
Angeles TherapeuticsSimvastatin
MSDEnlicitide
Chong Kun Dang PharmaceuticalAtorvastatin10mg, Ezetimibe10mg
PfizerBococizumab
PfizerBococizumab
PfizerBococizumab
OtsukaProbucol
Hanmi PharmaceuticalSimvastatin CR
AbbottNiacin ER/Simvastatin Tablets

Showing 15 of 31 trials with date data

Clinical Trials (31)

Total enrollment: 10,829 patients across 31 trials

Exploratory Study of the Effects of Omega-3-acid Ethyl Esters on the Lipid and Lipoprotein Profile in the Blood

Start: Dec 2016Est. completion: Aug 201753 patients
Phase 4Completed

Exploratory Study of the Effect of Omega-3-acid Ethyl Esters (TAK-085) on Vascular Endothelial Function in Patients With Hyperlipidemia by Flow Mediated Dilation

Start: Aug 2016Est. completion: Aug 201737 patients
Phase 4Completed

Comparison of the Efficacy and Safety of Cresnon® and Crestor® in Patients With Hyperlipidemia

Start: Sep 2014223 patients
Phase 4Completed
NCT01212159MSDSelf Monitoring Lipid Analyzer

Telephone Based Management of Hyperlipidemia

Start: Nov 2010Est. completion: Aug 201570 patients
Phase 4Completed
NCT00753883MSDsimvastatin

Ezetrol Post-Marketing Study

Start: Jul 200640 patients
Phase 4Completed
NCT00249938Colorado TherapeuticsMinute Maid Heart Wise orange juice

Evaluation of Combination Cholesterol Treatments in Patients With High Cholesterol.

Start: Mar 2005Est. completion: Aug 200660 patients
Phase 4Completed

Cholesterol and Pharmacogenetic Study

Start: Mar 20021,000 patients
Phase 4Completed
NCT07216482MSDEnlicitide

A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

Start: Nov 2025Est. completion: Mar 2027975 patients
Phase 3Recruiting
NCT02451098Chong Kun Dang PharmaceuticalAtorvastatin10mg, Ezetimibe10mg

Clinical Trial to Evaluate the Efficacy and Safety of CKD-391

Start: Mar 2015Est. completion: Jan 2016385 patients
Phase 3Completed

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Primary Hyperlipidemia or Mixed Dyslipidemia At Risk Of Cardiovascular Events

Start: Oct 2014Est. completion: Jul 2017746 patients
Phase 3Completed

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Start: Oct 2013Est. completion: Jul 20172,139 patients
Phase 3Completed

Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

Start: Oct 2013Est. completion: Apr 2016711 patients
Phase 3Completed

Efficacy and Safety of Imported Probucol to Treat Hyperlipidemia

Start: Apr 2011Est. completion: Feb 2013264 patients
Phase 3Completed

Efficacy and Safety of Morning Versus Evening Intake of Simvast Controlled Release (CR) Tablet in Patients With Hyperlipidemia

Start: Nov 2007Est. completion: Aug 2009132 patients
Phase 3Completed
NCT00465088AbbottNiacin ER/Simvastatin Tablets

An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)

Start: Apr 2007199 patients
Phase 3Completed

A 16 Week Comparative Study of Fenofibrate Versus Ezetimibe as Add-on Therapy to Atorvastatin

Start: Aug 2004174 patients
Phase 3Completed

Efficacy and Safety Study of Nidadd in the Management of Hyperlipidemia

Start: Oct 2003Est. completion: Aug 200570 patients
Phase 3Completed
NCT00566267MSDsimvastatin 20 mg/ezetimibe

A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet

Start: Apr 2006Est. completion: Nov 200758 patients
Phase 2/3Completed

Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease

Start: Sep 2016Est. completion: Mar 201959 patients
Phase 2Completed

Comparison of SLx-4090 Combined With Statin Therapy Versus Statin Alone in Reducing LDL-C in Patients With Hyperlipidemia

Start: Jan 2009Est. completion: Sep 2009133 patients
Phase 2Completed
NCT04774003Novartis100 mg inclisiran sodium

Study of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inclisiran in Chinese Participants With Elevated Serum LDL-C

Start: Feb 2021Est. completion: Oct 202140 patients
Phase 1Completed

Clinical Trial to Investigate the Pharmacokinetics Drug Interaction Between Metformin and Rosuvastatin

Start: Aug 2014Est. completion: Feb 201524 patients
Phase 1Completed
NCT01764178JW PharmaceuticalLivalo fixed combination drug

To Evaluate the Safety and PK Characteristics in Healthy Volunteers-Livalozet

Start: Jan 2013Est. completion: Dec 201352 patients
Phase 1Completed

Pharmacokinetic Study of Pitavastatin and Ritonavir-Boosted Darunavir or Efavirenz

Start: May 2012Est. completion: Jan 201334 patients
Phase 1Completed
NCT01406431JW PharmaceuticalPitavastatin, Valsartan

Pharmacokinetic Study of Livalo® Fixed Combination Drug in Healthy Subjects

Start: Aug 2011Est. completion: Oct 201248 patients
Phase 1Completed
NCT07334834Colorado TherapeuticsAlgorithm- and multi-professional team-supported lipid management

Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease

Start: Dec 2025Est. completion: Jul 2027100 patients
N/ARecruiting

Acute Microvascular Changes With LDL Apheresis

Start: Mar 2015Est. completion: Jul 20188 patients
N/ACompleted
NCT01571609Lundbeckfirst phase insulin secretion

Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders

Start: Aug 2012Est. completion: Nov 201440 patients
N/ACompleted
NCT02029989Medica CorpGlucose and lipids

Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness

Start: Feb 2010Est. completion: Feb 2012121 patients
N/ACompleted
NCT00828945PfizerLipid Self Test

Compliance With Treatment For Patients With Hyperlipidemia

Start: Feb 2009Est. completion: Mar 2011259 patients
N/ACompleted
NCT00781560AstraZenecaAwareness of Chinese National Adult Lipid Treatment Guideline (2007) and Rate of Patients Achieving

Awareness of Chinese National Adult Lipid Treatment Guideline (2007) and Rate of Patients Achieving the Treatment Goal

Start: Oct 2008Est. completion: Jul 20092,575 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 10,829 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.