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Hyperkalaemia

8
Pipeline Programs
2
Companies
8
Clinical Trials
1 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
2
5
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

AstraZeneca
LOKELMAApproved
sodium zirconium cyclosilicate
AstraZeneca
oral2018
205M Part D
AstraZeneca
SODIUM ZIRCONIUM CYCLOSILICATEApproved
sodium zirconium cyclosilicate
AstraZeneca

Competitive Landscape

2 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
8 programs
1
2
3
Sodium Zirconium CyclosilicatePhase 41 trial
Sodium Zirconium CyclosilicatePhase 41 trial
Sodium zirconium cyclosilicatePhase 41 trial
Sodium Zirconium CyclosilicatePhase 31 trial
Sodium zirconium cyclosilicatePhase 31 trial
+3 more programs
Active Trials
NCT05462119Completed887Est. Dec 2023
NCT06185660Completed125Est. Jan 2025
NCT04788641Completed62Est. Sep 2021
+5 more trials
Parexel
ParexelMA - Boston
1 program
TacrolimusPHASE_1

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
AstraZenecaSodium Zirconium Cyclosilicate
AstraZenecaSodium Zirconium Cyclosilicate
AstraZenecaSodium zirconium cyclosilicate
AstraZenecaSodium zirconium cyclosilicate
AstraZenecaSodium Zirconium Cyclosilicate
AstraZenecaTacrolimus
AstraZenecasodium zirconium cyclosilicate
AstraZenecaSafety of Oral Resin for Treatment of Hyperkalemia in Chinese Patients With Renal Insufficiency

Clinical Trials (8)

Total enrollment: 1,808 patients across 8 trials

NCT05347693AstraZenecaSodium Zirconium Cyclosilicate

Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge Study

Start: Mar 2022Est. completion: Dec 2024186 patients
Phase 4Completed
NCT04997161AstraZenecaSodium Zirconium Cyclosilicate

Study of SZC and Enhanced Nutrition Advice Compared to SoC in Dialysis Patients With Hyperkalaemia

Start: Aug 2021Est. completion: Nov 20213 patients
Phase 4Terminated
NCT04676646AstraZenecaSodium zirconium cyclosilicate

Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone

Start: Mar 2021Est. completion: Jul 2024366 patients
Phase 4Completed
NCT04727528AstraZenecaSodium zirconium cyclosilicate

Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease

Start: Mar 2021Est. completion: Sep 202239 patients
Phase 3Terminated
NCT03813407AstraZenecaSodium Zirconium Cyclosilicate

An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia

Start: Apr 2019Est. completion: Feb 2030140 patients
Phase 3Recruiting

Study to Assess the Effect of Sodium Zirconium Cyclosilicate on the Pharmacokinetics of Tacrolimus and Cyclosporin in Healthy Subjects

Start: Mar 2021Est. completion: Sep 202162 patients
Phase 1Completed
NCT06185660AstraZenecasodium zirconium cyclosilicate

A National, Multicenter, Prospective, Observational Study to Assess Patient Characteristics, Treatment Algorithms and Disease Management of Hyperkalaemia Patients With Chronic Kidney Disease or Under Dialysis or With Heart Failure, Treated With Sodium Zirconium Cyclosilicate in Greece

Start: Feb 2024Est. completion: Jan 2025125 patients
N/ACompleted
NCT05462119AstraZenecaSafety of Oral Resin for Treatment of Hyperkalemia in Chinese Patients With Renal Insufficiency

Safety of Oral Resin for Treatment of Hyperkalemia in Chinese Patients With Renal Insufficiency

Start: Aug 2022Est. completion: Dec 2023887 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 1,808 patients
2 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.