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Hyperglycemia

8
Pipeline Programs
19
Companies
17
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
0
0
2
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 21 programs with unclassified modality

Competitive Landscape

19 companies ranked by most advanced pipeline stage

Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
1 program
1
InsulinPhase 41 trial
Active Trials
NCT00779701Completed27Est. Oct 2009
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
MetforminPhase 41 trial
Active Trials
NCT06280274Completed40Est. Sep 2025
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
conventional empirical glycemic controlPhase 41 trial
Active Trials
NCT02491346Unknown46Est. Sep 2015
Baxter
BaxterCosta Rica - Cartago
1 program
1
CGAO-based Glucose ControlPhase 3
Prevail Therapeutics
1 program
1
Human regular insulinPhase 31 trial
Active Trials
NCT01136746Terminated16Est. Nov 2011
Admetsys
AdmetsysMA - Boston
1 program
1
Insulin Balanced Infusion SystemPhase 1/21 trial
Active Trials
NCT01291719Active Not Recruiting40Est. Nov 2026
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
GLP-1 controlPhase 1
MSD
MSDIreland - Ballydine
1 program
1
GLP-1 controlPhase 11 trial
Active Trials
NCT00393445Completed6Est. May 2007
Medtronic
MedtronicNJ - Phillipsburg
2 programs
Continuous Glucose Monitoring in Critically Ill Surgical PatientsN/A1 trial
Regular Insulin via Insulin-Glucose AlgorithmN/A1 trial
Active Trials
NCT01108640Completed24Est. Jul 2012
NCT00240149Completed0Est. Mar 2006
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
DiabetesN/A1 trial
Freestyle Libre 3 Continuous Glucose MonitorN/A1 trial
Active Trials
NCT02372539Withdrawn0Est. Oct 2020
NCT06143202Enrolling By Invitation120Est. Feb 2027
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
Jasmine riceN/A1 trial
Study nutritional drinkN/A1 trial
Active Trials
NCT01804738Completed75Est. Jun 2014
NCT02509988Completed1,729Est. Jun 2022
Innovation Pharmaceuticals
1 program
Commercial white breadN/A1 trial
Active Trials
NCT02075788Completed12Est. Jun 2015
Dexcom
DexcomCA - San Diego
1 program
Continuous glucose monitoringN/A1 trial
Active Trials
NCT05442853Completed85Est. Aug 2024
Eppendorf
EppendorfGermany - Hamburg
1 program
Space GlucoseControl System, B. Braun, Melsungen, GermanyN/A
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
liraglutideN/APeptide1 trial
Active Trials
NCT01472640Completed240Est. Oct 2015
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
GLP-1 controlPHASE_1
Chia Tai TianQing Pharmaceutical Group
1 program
TQF3250 placeboPHASE_11 trial
Active Trials
NCT07327281Recruiting66Est. Dec 2026
Baxter International
1 program
CGAO-based Glucose ControlPHASE_31 trial
Active Trials
NCT01002482Completed2,684Est. Apr 2013
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
Human regular insulinPHASE_3

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Oregon TherapeuticsMetformin
UNION therapeuticsconventional empirical glycemic control
Temple TherapeuticsInsulin
Prevail TherapeuticsHuman regular insulin
Baxter InternationalCGAO-based Glucose Control
AdmetsysInsulin Balanced Infusion System
Chia Tai TianQing Pharmaceutical GroupTQF3250 placebo
MSDGLP-1 control
Colorado TherapeuticsFreestyle Libre 3 Continuous Glucose Monitor
DexcomContinuous glucose monitoring
Human BioSciencesStudy nutritional drink
Colorado TherapeuticsDiabetes
Innovation PharmaceuticalsCommercial white bread
Human BioSciencesJasmine rice
Novo Nordiskliraglutide

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 5,210 patients across 17 trials

NCT06280274Oregon TherapeuticsMetformin

Metformin Use in Patients Undergoing Total Joint Replacement Surgery

Start: Jun 2024Est. completion: Sep 202540 patients
Phase 4Completed
NCT02491346UNION therapeuticsconventional empirical glycemic control

A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU

Start: Oct 2014Est. completion: Sep 201546 patients
Phase 4Unknown
NCT00779701Temple TherapeuticsInsulin

Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation

Start: Mar 2007Est. completion: Oct 200927 patients
Phase 4Completed
NCT01136746Prevail TherapeuticsHuman regular insulin

Hospital Management of Hyperglycemia Study of Insulin Glargine Plus Insulin Lispro Versus Human Regular Insulin

Start: Mar 2011Est. completion: Nov 201116 patients
Phase 3Terminated
NCT01002482Baxter InternationalCGAO-based Glucose Control

Computerized Glucose Control in Critically Ill Patients

Start: Oct 2009Est. completion: Apr 20132,684 patients
Phase 3Completed
NCT01291719AdmetsysInsulin Balanced Infusion System

Insulin Balanced Infusion System

Start: Nov 2008Est. completion: Nov 202640 patients
Phase 1/2Active Not Recruiting
NCT07327281Chia Tai TianQing Pharmaceutical GroupTQF3250 placebo

A Clinical Trial Evaluating TQF3250 Capsules in Healthy Adult Subjects

Start: Dec 2025Est. completion: Dec 202666 patients
Phase 1Recruiting
NCT00393445MSDGLP-1 control

Exendin(9-39)Amide as a Glucagon-like Peptide-1 (GLP-1) Receptor Antagonist in Humans

Start: Nov 2006Est. completion: May 20076 patients
Phase 1Completed
NCT06143202Colorado TherapeuticsFreestyle Libre 3 Continuous Glucose Monitor

Feasibility of CGM Use in Hospitalized Youth

Start: Jul 2025Est. completion: Feb 2027120 patients
N/AEnrolling By Invitation
NCT05442853DexcomContinuous glucose monitoring

Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients

Start: Apr 2023Est. completion: Aug 202485 patients
N/ACompleted
NCT02509988Human BioSciencesStudy nutritional drink

Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health

Start: Jul 2015Est. completion: Jun 20221,729 patients
N/ACompleted
NCT02372539Colorado TherapeuticsDiabetes

Glucose Variability in Cancer Patients Receiving Dexamethasone

Start: Jan 2015Est. completion: Oct 20200
N/AWithdrawn
NCT02075788Innovation PharmaceuticalsCommercial white bread

Millet Products Study - Investigation of Glycemic Index and Satiety

Start: Jan 2014Est. completion: Jun 201512 patients
N/ACompleted
NCT01804738Human BioSciencesJasmine rice

Investigating Inter-individual Variability in Glycemic and Insulin Responses

Start: Mar 2013Est. completion: Jun 201475 patients
N/ACompleted
NCT01472640Novo Nordiskliraglutide

The Effect of Liraglutide on Left Ventricular Function in Chronic Heart Failure Patients With and Without Type 2 Diabetes Mellitus

Start: Nov 2011Est. completion: Oct 2015240 patients
N/ACompleted
NCT01108640MedtronicContinuous Glucose Monitoring in Critically Ill Surgical Patients

Continuous Glucose Monitoring in Critically Ill Surgical Patients

Start: Apr 2010Est. completion: Jul 201224 patients
N/ACompleted
NCT00240149MedtronicRegular Insulin via Insulin-Glucose Algorithm

Pilot Study to Evaluate a Method of Controlling High Blood Sugar in the Pediatric Intensive Care Unit

Start: Oct 2005Est. completion: Mar 20060
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 5,210 patients
19 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.