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Hypereosinophilic Syndrome

11
Pipeline Programs
4
Companies
6
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
5
0
5
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
9100%
+ 6 programs with unclassified modality

On Market (1)

Approved therapies currently available

GSK
NUCALAApproved
mepolizumab
GSK
Interleukin-5 Antagonist [EPC]subcutaneous lyophilized power2015
261M Part D

Competitive Landscape

4 companies ranked by most advanced pipeline stage

GSK
GSKLONDON, United Kingdom
4 programs
1
MepolizumabN/AMonoclonal Antibody1 trial
MepolizumabPHASE_3Monoclonal Antibody1 trial
MepolizumabPHASE_3Monoclonal Antibody1 trial
mepolizumabPHASE_3Monoclonal Antibody1 trial
Active Trials
NCT00244686No Longer Available
NCT04965636Completed16Est. Oct 2025
NCT03306043Completed102Est. Dec 2019
+1 more trials
ViiV Healthcare
ViiV HealthcareNC - Durham
6 programs
5
DepemokimabPhase 3Monoclonal Antibody
MepolizumabPhase 3Monoclonal Antibody
MepolizumabPhase 3Monoclonal Antibody
Mepolizumab 300 mgPhase 3
mepolizumabPhase 3Monoclonal Antibody
+1 more programs
Sandoz
SandozAustria - Kundl
3 programs
3
STI571Phase 2
imatinib mesylatePhase 2
imatinib mesylatePhase 2
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
2 programs
2
DexpramipexolePhase 21 trial
SCH55700Phase 21 trial
Active Trials
NCT02101138Unknown15Est. Oct 2019
NCT00017862Completed10Est. Jun 2003

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKMepolizumab
GSKMepolizumab
GSKmepolizumab
Allergy TherapeuticsDexpramipexole
Allergy TherapeuticsSCH55700

Clinical Trials (6)

Total enrollment: 221 patients across 6 trials

NCT04965636GSKMepolizumab

Study in Pediatrics With HypEREosinophilic Syndrome (SPHERE)

Start: Jul 2022Est. completion: Oct 202516 patients
Phase 3Completed
NCT03306043GSKMepolizumab

A Multi-center, Open-label Extension, Safety Study of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES) From Study 200622

Start: Nov 2017Est. completion: Dec 2019102 patients
Phase 3Completed
NCT00097370GSKmepolizumab

Open-Label Extension Of Intravenous Mepolizumab In Patients With Hypereosinophilic Syndrome

Start: Sep 2004Est. completion: Sep 201078 patients
Phase 3Terminated

Study to Evaluate Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects With Hypereosinophilic Syndrome

Start: Mar 2014Est. completion: Oct 201915 patients
Phase 2Unknown

Anti-Interleukin-5 Antibody to Treat Hypereosinophilic Syndrome

Start: Jun 2001Est. completion: Jun 200310 patients
Phase 2Completed
NCT00244686GSKMepolizumab

This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic

N/ANo Longer Available

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
Monoclonal Antibody is the dominant modality (100% of programs)
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.