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Hyperammonemia

2
Pipeline Programs
3
Companies
4
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

TenNor Therapeutics
TenNor TherapeuticsChina - Suzhou
2 programs
1
1
TNP-2092 capsulesPhase 1/21 trial
TNP-2092 capsulesPhase 11 trial
Active Trials
NCT06178718Completed58Est. Aug 2016
NCT06135675Completed36Est. Jun 2021
Recordati
RecordatiFrance - Saint-Victor
1 program
Carglumic AcidN/A1 trial
Active Trials
NCT05040178Recruiting20Est. Jun 2032
Liminal BioSciences
1 program
FezageprasPHASE_11 trial
Active Trials
NCT05349435Terminated8Est. Jun 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
TenNor TherapeuticsTNP-2092 capsules
Liminal BioSciencesFezagepras
TenNor TherapeuticsTNP-2092 capsules
RecordatiCarglumic Acid

Clinical Trials (4)

Total enrollment: 122 patients across 4 trials

PK Profile and Preliminary Efficacy of TNP-2092 Capsules in Liver Cirrhosis Patients With Hyperammonemia

Start: Aug 2020Est. completion: Jun 202136 patients
Phase 1/2Completed

A Healthy Volunteer Study to Compare Fezagepras (PBI-4050) With Sodium Phenylbutyrate

Start: May 2022Est. completion: Jun 20228 patients
Phase 1Terminated

A Phase 1 Study to Evaluate PK Profile and Food Effects on PK Parameters of TNP-2092 Capsules

Start: Jun 2016Est. completion: Aug 201658 patients
Phase 1Completed
NCT05040178RecordatiCarglumic Acid

An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics

Start: Jun 2022Est. completion: Jun 203220 patients
N/ARecruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 122 patients
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.