Hydrocephalus

Pipeline Programs

Companies

Clinical Trials

7 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

NeuroDx DevelopmentPA - Yardley

2 programs

ShuntCheck testPhase 41 trial

Fit & Function testN/A1 trial

Active Trials

NCT02067364Unknown20Est. Aug 2015

NCT01323764Completed20Est. Jul 2015

Colorado TherapeuticsCO - Louisville

2 programs

Endoscopic Third Ventriculostomy with Choroid Plexus CauterizationPhase 3

Pulse oximetryN/A1 trial

Active Trials

NCT02404740Completed163Est. Sep 2018

Utah MedicalIreland - Dublin

1 program

Endoscopic Third Ventriculostomy with Choroid Plexus CauterizationPhase 31 trial

Active Trials

NCT04177914Recruiting176Est. Aug 2027

Angeles TherapeuticsCA - Los Angeles

1 program

Endoscopic Third Ventriculostomy with Choroid Plexus CauterizationPhase 3

RhaeosIL - Evanston

14 programs

FlowSenseN/A1 trial

Rhaeos Shunt Monitoring SystemN/A1 trial

+9 more programs

Active Trials

NCT06513572Terminated10Est. Jul 2024

NCT06524492Completed52Est. Jul 2024

NCT06506045Terminated10Est. Jul 2024

+11 more trials

Integra LifeSciencesAustralia - Clayton

5 programs

Bactiseal CatheterN/A1 trial

CODMAN CERTAS Plus Programmable ValveN/A1 trial

CODMAN CERTAS Programmable ValvesN/A1 trial

Hakim Shunt Programmable SystemN/A1 trial

antibiotic-impregnated catheterN/A1 trial

Active Trials

NCT04496414Completed50Est. Nov 2020

NCT05397106Active Not Recruiting160Est. Jan 2029

NCT04207229Completed35Est. Nov 2021

+2 more trials

CereVascMA - Charlestown

1 program

eShunt® ImplantN/A1 trial

Active Trials

NCT05501002Terminated4Est. Sep 2023

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

NeuroDx DevelopmentShuntCheck test

Utah MedicalEndoscopic Third Ventriculostomy with Choroid Plexus Cauterization

RhaeosRhaeos Shunt Monitoring System

RhaeosThermal Anisotropy Measurement Device

Rhaeoswireless thermal anisotropy measurement device

RhaeosThermal Anisotropy Measurement Device

Rhaeoswireless thermal anisotropy measurement device

Rhaeoswireless wearable thermal anisotropy measurement device

Integra LifeSciencesantibiotic-impregnated catheter

RhaeosFlowSense

RhaeosThermal Anisotropy Measurement Device

RhaeosThermal Anisotropy

RhaeosFlowSense

Showing 15 of 24 trials with date data

Clinical Trials (24)

Total enrollment: 1,715 patients across 24 trials

NCT01323764 NeuroDx DevelopmentShuntCheck test

ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients

Start: Jun 2011Est. completion: Jul 201520 patients

Phase 4Completed

NCT04177914 Utah MedicalEndoscopic Third Ventriculostomy with Choroid Plexus Cauterization

HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants

Start: Jul 2020Est. completion: Aug 2027176 patients

Phase 3Recruiting

NCT07478926 RhaeosRhaeos Shunt Monitoring System

Flow Detection in Open and Closed Shunt Valve Periods

Start: Jan 2026Est. completion: Dec 202655 patients

N/ARecruiting

NCT06409286 RhaeosThermal Anisotropy Measurement Device

Assessment of Flow in Cerebrospinal Fluid Shunts With a Second Generation Wireless Thermal Anisotropy Measurement Device

Start: Jul 2025Est. completion: Dec 202517 patients

N/ANot Yet Recruiting

NCT07050628 Rhaeoswireless thermal anisotropy measurement device

Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement Device

Start: Jul 2025Est. completion: Dec 202520 patients

N/ANot Yet Recruiting

NCT06410885 RhaeosThermal Anisotropy Measurement Device

Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asymptomatic Patients

Start: Jun 2025Est. completion: May 202660 patients

N/ANot Yet Recruiting

NCT06996600 Rhaeoswireless thermal anisotropy measurement device

Assessment of CSF Shunt Flow and Headaches With a Thermal Measurement Device

Start: May 2025Est. completion: Dec 202529 patients

N/ARecruiting

NCT06753929 Rhaeoswireless wearable thermal anisotropy measurement device

Assessment of CSF Shunt Flow in an Outpatient Setting with a Thermal Measurement Device

Start: Dec 2024Est. completion: Feb 202520 patients

N/ACompleted

NCT06276543 Integra LifeSciencesantibiotic-impregnated catheter

Bactiseal Catheter Safety Registry Study

Start: Sep 2024Est. completion: Dec 2026200 patients

N/ARecruiting

NCT06506045 RhaeosFlowSense

Functional and Non-Functional CSF Shunt Flow Measured With a Second-Generation Wireless Thermal Device

Start: Jul 2024Est. completion: Jul 202410 patients

N/ATerminated

NCT06524492 RhaeosFlowSense

Flow Measurements in Functional CSF Shunts and Off-Shunt Locations with a Second-Generation Thermal Device

Start: Jul 2024Est. completion: Jul 202452 patients

N/ACompleted

NCT06513572 RhaeosFlowSense

Measurements of CSF Shunts and Off-Shunt Locations With Wireless Thermal Anisotropy Measurement Devices

Start: Jul 2024Est. completion: Jul 202410 patients

N/ATerminated

NCT06086561 RhaeosThermal Anisotropy Measurement Device

Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device

Start: Nov 2023Est. completion: Dec 2025130 patients

N/ARecruiting

NCT06040697 RhaeosThermal Anisotropy

Formative Usability Assessment of Wireless Thermal Anisotropy Devices

Start: Sep 2023Est. completion: Dec 2025145 patients

N/ARecruiting

NCT05546996 RhaeosFlowSense

EVD Drainage Data and Intracranial Pressure (ICP) Measurements

Start: Jul 2023Est. completion: Jan 202724 patients

N/ARecruiting

NCT05397106 Integra LifeSciencesCODMAN CERTAS Plus Programmable Valve

Post Market Clinical Follow-up of CODMAN CERTAS Programmable Valve

Start: Jan 2023Est. completion: Jan 2029160 patients

N/AActive Not Recruiting

NCT05501002 CereVasceShunt® Implant

Pilot Study to Evaluate the CereVasc® EShunt® System in the Treatment of Communicating Hydrocephalus

Start: Sep 2022Est. completion: Sep 20234 patients

N/ATerminated

NCT05432986 RhaeosThermal Anisotropy Measurement Device

Assessment of CSF Shunt Flow With Thermal Measurements B

Start: Jul 2022Est. completion: Nov 2023141 patients

N/ACompleted

NCT05015751 RhaeosThermal Anisotropy Measurement Device

Assessment of CSF Shunt Flow With Thermal Measurements A

Start: Aug 2021Est. completion: Jul 202244 patients

N/ACompleted

NCT04496414 Integra LifeSciencesBactiseal Catheter

Bactiseal Catheter Safety Registry in China

Start: Sep 2020Est. completion: Nov 202050 patients

N/ACompleted

NCT04285489 Integra LifeSciencesHakim Shunt Programmable System

A Study on the Safety of Hakim Programmable Shunt System

Start: May 2020Est. completion: Jul 2020130 patients

N/ACompleted

NCT04207229 Integra LifeSciencesCODMAN CERTAS Programmable Valves

CERTAS Programmable Valve Registry

Start: Nov 2019Est. completion: Nov 202135 patients

N/ACompleted

NCT02404740 Colorado TherapeuticsPulse oximetry

Noninvasive Intracranial Pressure and Hydrocephalus Patients

Start: Feb 2015Est. completion: Sep 2018163 patients

N/ACompleted

NCT02067364 NeuroDx DevelopmentFit & Function test

CRT ShuntCheck "Fit & Function" Study

Start: Jan 2014Est. completion: Aug 201520 patients

N/AUnknown

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals

7 actively recruiting trials targeting 1,715 patients

8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.