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Human Papillomavirus

5
Pipeline Programs
12
Companies
13
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
0
2
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
2100%
+ 26 programs with unclassified modality

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
8 programs
1
1
V503Phase 3
GardasilPhase 2
Gardasil vaccineN/AVaccine
Human Papillomavirus (HPV) Infection in Young Men Who Have Sex With MenN/A
Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)N/A
+3 more programs
MSD
MSDIreland - Ballydine
8 programs
1
1
V503Phase 31 trial
GardasilPhase 21 trial
Gardasil vaccineN/AVaccine1 trial
Human Papillomavirus (HPV) Infection in Young Men Who Have Sex With MenN/A1 trial
Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)N/A1 trial
+3 more programs
Active Trials
NCT01446718Completed179Est. Jun 2018
NCT01422356Completed200Est. Sep 2013
NCT01159834Completed1,574Est. Dec 2011
+5 more trials
Genexine
GenexineKorea - Seoul
1 program
1
GX-I7Phase 11 trial
Active Trials
NCT03144934Completed32Est. Mar 2018
Merck & Co.
Merck & Co.RAHWAY, NJ
5 programs
Human Papillomavirus (HPV) Infection in Young Men Who Have Sex With MenN/A
Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)N/A
Human Papillomavirus in Young People Epidemiological Research 2 (HYPER2)N/A
KAP/WTP and HPV Prevalence Studies in a Developing World Setting (Bamako, Mali)N/A
Prevalence, Persistence, and Risk Factors for Oral Human Papillomavirus (HPV) Infections in College N/A
Abbott
AbbottABBOTT PARK, IL
1 program
Alinity m HR HPVN/A1 trial
Active Trials
NCT04746872Completed14,935Est. Nov 2022
Alliance Pharmaceuticals
1 program
KAP/WTP and HPV Prevalence Studies in a Developing World Setting (Bamako, Mali)N/A
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Natural History of HPV From Infection to Neoplasia in Adolescents and Young WomenN/A1 trial
Active Trials
NCT01366742Completed900Est. May 2016
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)N/A1 trial
Active Trials
NCT05026138Recruiting850Est. Mar 2047
Pfizer
PfizerNEW YORK, NY
1 program
ParticipatoryN/A
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
ParticipatoryN/A1 trial
Active Trials
NCT02377843Completed30Est. Mar 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
MSDV503
MSDGardasil
GenexineGX-I7
Allergy TherapeuticsNatural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)
AbbottAlinity m HR HPV
MSDHuman Papillomavirus in Young People Epidemiological Research 2 (HYPER2)
Human BioSciencesParticipatory
MSDGardasil vaccine
MSDPrevalence, Persistence, and Risk Factors for Oral Human Papillomavirus (HPV) Infections in College
MSDKAP/WTP and HPV Prevalence Studies in a Developing World Setting (Bamako, Mali)
MSDHuman Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)
MSDHuman Papillomavirus (HPV) Infection in Young Men Who Have Sex With Men
Angeles TherapeuticsNatural History of HPV From Infection to Neoplasia in Adolescents and Young Women

Clinical Trials (13)

Total enrollment: 21,146 patients across 13 trials

NCT01304498MSDV503

Immunogenicity and Tolerability of V503 Versus GARDASIL (V503-009)

Start: Feb 2011Est. completion: Dec 2011600 patients
Phase 3Completed
NCT01432574MSDGardasil

Study of Gardasil in Mid-Adult Males (MAM)

Start: Feb 2013Est. completion: Nov 2020150 patients
Phase 2Completed
NCT03144934GenexineGX-I7

Safety and Tolerability of GX-I7 in HPV-infected Female Volunteers

Start: Feb 2017Est. completion: Mar 201832 patients
Phase 1Completed
NCT05026138Allergy TherapeuticsNatural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

Start: Nov 2021Est. completion: Mar 2047850 patients
N/ARecruiting
NCT04746872AbbottAlinity m HR HPV

Alinity m HR HPV Specimen Collection Study From Women Undergoing Routine Cervical Cancer Screening

Start: Feb 2021Est. completion: Nov 202214,935 patients
N/ACompleted
NCT03000933MSDHuman Papillomavirus in Young People Epidemiological Research 2 (HYPER2)

Human Papillomavirus in Young People Epidemiological Research 2 (HYPER2)

Start: Jan 2017Est. completion: Dec 2019200 patients
N/ACompleted
NCT02377843Human BioSciencesParticipatory

Making Effective Human Papillomavirus (HPV) Vaccine Recommendations

Start: Mar 2015Est. completion: Mar 201630 patients
N/ACompleted
NCT01446718MSDGardasil vaccine

A Cohort Study to Assess Sustained Immunogenicity to qHPV Vaccine Among HIV-infected Girls and Boys Age 9-14 Years

Start: Dec 2014Est. completion: Jun 2018179 patients
N/ACompleted
NCT01289873MSDPrevalence, Persistence, and Risk Factors for Oral Human Papillomavirus (HPV) Infections in College

Prevalence, Persistence, and Risk Factors for Oral Human Papillomavirus (HPV) Infections in College Women

Start: May 2011Est. completion: Sep 20121,036 patients
N/ACompleted
NCT01314404MSDKAP/WTP and HPV Prevalence Studies in a Developing World Setting (Bamako, Mali)

KAP/WTP and HPV Prevalence Studies in a Developing World Setting (Bamako, Mali)

Start: Mar 2011Est. completion: Sep 2012460 patients
N/AUnknown
NCT01159834MSDHuman Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)

Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)

Start: Sep 2010Est. completion: Dec 20111,574 patients
N/ACompleted
NCT01422356MSDHuman Papillomavirus (HPV) Infection in Young Men Who Have Sex With Men

Human Papillomavirus (HPV) Infection in Young Men Who Have Sex With Men

Start: Sep 2010Est. completion: Sep 2013200 patients
N/ACompleted
NCT01366742Angeles TherapeuticsNatural History of HPV From Infection to Neoplasia in Adolescents and Young Women

Natural History of HPV From Infection to Neoplasia in Adolescents and Young Women

Start: Dec 1987Est. completion: May 2016900 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 21,146 patients
12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.