Herpes Zoster

19
Pipeline Programs
5
Companies
23
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
2
0
12
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
1493%
RNA Therapeutic
17%
+ 7 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

M&
Merck & Co.RAHWAY, NJ
12 programs
7
2
ZOSTAVAX®Phase 41 trial
Zoster Vaccine LivePhase 4Vaccine1 trial
Comparator: zoster vaccine livePhase 3Vaccine1 trial
V212Phase 33 trials
ZOSTAVAXPhase 31 trial
+7 more programs
Active Trials
NCT01483378Completed170Est. Feb 2012
NCT00689013Completed205Est. Mar 2008
NCT01600079Completed1,505,647Est. Oct 2020
+12 more trials
MAXVAX Biotechnology
MAXVAX BiotechnologyChina - Chengdu
5 programs
1
1
3
Recombinant Zoster VaccinePhase 3Vaccine1 trial
Recombinant Zoster VaccinePhase 3Vaccine1 trial
Recombinant Zoster VaccinePhase 3Vaccine1 trial
Low dose Recombinant Herpes Zoster VaccinePhase 2Vaccine1 trial
Low Dose Recombinant Herpes Zoster VaccinePhase 1Vaccine1 trial
Active Trials
NCT05636436Active Not RecruitingEst. Dec 2024
NCT05856084Active Not RecruitingEst. Mar 2026
NCT07293065Active Not RecruitingEst. Dec 2028
+2 more trials
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
3 programs
1
1
1
Varicella-zoster vaccinePhase 3Vaccine
ZOSTAVAXPhase 2
Live attenuated herpes zoster vaccinePhase 1Vaccine1 trial
Active Trials
NCT01137669CompletedEst. Feb 2015
LP
Lee's PharmaceuticalChina - Guangzhou
1 program
1
Recombinant Human Interferon α-2b GelPhase 31 trial
Active Trials
NCT05806918Unknown368Est. Aug 2023
Moderna
ModernaCAMBRIDGE, MA
1 program
1
mRNA-1468Phase 1/2RNA Therapeutic1 trial
Active Trials
NCT05701800Active Not Recruiting659Est. Jun 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Merck & Co.Zoster Vaccine Live
Merck & Co.ZOSTAVAX®
MAXVAX BiotechnologyRecombinant Zoster Vaccine
MAXVAX BiotechnologyRecombinant Zoster Vaccine
MAXVAX BiotechnologyRecombinant Zoster Vaccine
Lee's PharmaceuticalRecombinant Human Interferon α-2b Gel
Merck & Co.V212
Merck & Co.Zoster Vaccine Live
Merck & Co.Zoster Vaccine, Live
Merck & Co.ZOSTAVAX
Merck & Co.Zoster Vaccine, Live
Merck & Co.V212
Merck & Co.Zoster Vaccine, Live,
Merck & Co.Zoster Vaccine, Live,
Merck & Co.Comparator: zoster vaccine live

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 1,511,355 patients across 23 trials

NCT01556451Merck & Co.Zoster Vaccine Live

ZOSTAVAX™ Safety and Immunogenicity in Korean Adults (V211-034)

Start: Apr 2012Est. completion: Oct 2012180 patients
Phase 4Completed

Zostavax® at Minimum Release Specification Approaching Expiry (V211-044)

Start: May 2008Est. completion: Jun 200896 patients
Phase 4Completed
NCT07293065MAXVAX BiotechnologyRecombinant Zoster Vaccine

Long-term Efficacy of Recombinant Zoster Vaccine (CHO Cell) Study

Start: Dec 2025Est. completion: Dec 2028
Phase 3Active Not Recruiting
NCT06654700MAXVAX BiotechnologyRecombinant Zoster Vaccine

Phase III Clinical Trial of Lot-to-lot Consistency of Recombinant Herpes Zoster Vaccine (CHO Cell).

Start: Dec 2024Est. completion: May 2025
Phase 3Not Yet Recruiting
NCT06447779MAXVAX BiotechnologyRecombinant Zoster Vaccine

Efficacy, Safety and Immunogenicity Study of Recombinant Zoster Vaccine(CHO Cell) in Adults Aged 40 Years and Older

Start: Jul 2024Est. completion: Sep 2027
Phase 3Active Not Recruiting
NCT05806918Lee's PharmaceuticalRecombinant Human Interferon α-2b Gel

Non-inferiority Study of ZK-A03 in Treatment of Herpes Zoster Before and After the Alteration of the Active Ingredient Manufacturer

Start: Apr 2023Est. completion: Aug 2023368 patients
Phase 3Unknown

A Lot-to-Lot Consistency Study to Evaluate Safety, Tolerability, and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Healthy Adults (V212-014)

Start: Jul 2014Est. completion: Mar 20150
Phase 3Withdrawn
NCT01527370Merck & Co.Zoster Vaccine Live

Safety, Tolerability, and Immunogenicity of Zoster Vaccine Live (ZOSTAVAX™) in Healthy Adults in India (V211-025)

Start: Oct 2012Est. completion: Apr 2013250 patients
Phase 3Completed
NCT01505647Merck & Co.Zoster Vaccine, Live

Safety and Immunogenicity of Zoster Vaccine (ZOSTAVAX™) Made With an Alternative Manufacturing Process (AMP) (V211-042 AM1)

Start: Apr 2012Est. completion: Nov 2012498 patients
Phase 3Completed

Immunogenicity and Safety Study of ZOSTAVAX Administered by Intramuscular or Subcutaneous Route to Participants Aged From 50 Years Old (V211-045)

Start: Jun 2011Est. completion: Oct 2012354 patients
Phase 3Completed
NCT01245751Merck & Co.Zoster Vaccine, Live

Safety, Tolerability, and Immunogenicity of a Booster Dose of Zoster Vaccine, Live (V211-029)

Start: Apr 2011Est. completion: May 2015600 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (V212-001)

Start: Nov 2010Est. completion: Dec 20151,257 patients
Phase 3Completed
NCT00535730Merck & Co.Zoster Vaccine, Live,

ZOSTAVAX™ Administered Concomitantly With PNEUMOVAX™ 23 (V211-012)(COMPLETED)

Start: Jun 2007Est. completion: Feb 2008473 patients
Phase 3Completed
NCT00444860Merck & Co.Zoster Vaccine, Live,

ZOSTAVAX(R) Local Registration Trial (V211-019)

Start: Mar 2007Est. completion: May 2007150 patients
Phase 3Completed
NCT00130793Merck & Co.Comparator: zoster vaccine live

A Study to Evaluate Safety, Tolerability, and Immunogenicity of an Investigational Zoster Vaccine In Subjects With a History of Varicella (Chickenpox)(V211-010)(COMPLETED)

Start: Aug 2005Est. completion: Nov 2005368 patients
Phase 3Completed
NCT05856084MAXVAX BiotechnologyLow dose Recombinant Herpes Zoster Vaccine

Immunogenicity and Safety of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 30 Years and Above

Start: May 2023Est. completion: Mar 2026
Phase 2Active Not Recruiting

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age

Start: Jan 2023Est. completion: Jun 2026659 patients
Phase 1/2Active Not Recruiting
NCT05636436MAXVAX BiotechnologyLow Dose Recombinant Herpes Zoster Vaccine

Safety and Immunogenicity of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 18 Years and Above

Start: Dec 2022Est. completion: Dec 2024
Phase 1Active Not Recruiting

A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella-Zoster Virus (VZV) Vaccine in Adults With Hematologic Malignancies (HM) Receiving Treatment With Anti-Cluster of Differentiation (CD) 20 Monoclonal Antibodies (V212-013)

Start: Jan 2012Est. completion: Sep 201280 patients
Phase 1Completed
NCT01137669Allergy TherapeuticsLive attenuated herpes zoster vaccine

ZOSTAVAX® in Renal Transplant Patients

Start: Sep 2010Est. completion: Feb 2015
Phase 1Completed

ZOSTAVAX™ (Zoster Vaccine Live) Long-term Effectiveness Study (V211-024)

Start: May 2012Est. completion: Oct 20201,505,647 patients
N/ACompleted
NCT01483378Merck & Co.Choosing to receive the vaccine

Increasing Use of the Vaccine Against Herpes Zoster/Shingles at NYULMC and Bellevue Hospital

Start: Jan 2012Est. completion: Feb 2012170 patients
N/ACompleted
NCT00689013Merck & Co.Personalized letter

The Effect of Pharmacist Intervention on the Use of Zostavax in a Community Pharmacy Setting

Start: Feb 2008Est. completion: Mar 2008205 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs — potential near-term approvals
Vaccine is the dominant modality (93% of programs)
5 companies competing in this space