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Herpes Zoster

91
Pipeline Programs
18
Companies
50
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
13
4
12
0
53
9
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
7998%
RNA Therapeutic
11%
Small Molecule
11%
+ 73 programs with unclassified modality

Competitive Landscape

18 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
40 programs
1
1
4
24
2
RZVPhase 4
Recombinant zoster vaccinePhase 4Vaccine
GSK 1437173APhase 3
GSK Biologicals Herpes Zoster subunitPhase 3
GSK Biologicals Herpes Zoster subunitPhase 3
+35 more programs
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
28 programs
5
3
13
3
ZOSTAVAX®Phase 4
Zoster Vaccine LivePhase 4Vaccine
Zoster Vaccine, LivePhase 4Vaccine
Comparator: zoster vaccine livePhase 3Vaccine
V212Phase 3
+23 more programs
MSD
MSDIreland - Ballydine
28 programs
5
3
13
3
ZOSTAVAX®Phase 41 trial
Zoster Vaccine LivePhase 4Vaccine1 trial
Zoster Vaccine, LivePhase 4Vaccine1 trial
Comparator: zoster vaccine livePhase 3Vaccine1 trial
V212Phase 31 trial
+23 more programs
Active Trials
NCT01483378Completed170Est. Feb 2012
NCT02615470Completed120Est. Dec 2017
NCT00689013Completed205Est. Mar 2008
+24 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
1
1
ZostavaxPhase 41 trial
Zoster Vaccine, LivePhase 3Vaccine1 trial
Active Trials
NCT01245751Completed600Est. May 2015
NCT04169009Completed105Est. Jun 2024
Maruho
MaruhoJapan - Osaka
1 program
1
ASP2151Phase 31 trial
Active Trials
NCT01959841Completed751Est. Jul 2015
EMS
EMSBrazil - Hortolândia
1 program
1
FamciclovirPhase 3Small Molecule1 trial
Active Trials
NCT01327144Completed177Est. Jul 2017
Astellas
AstellasChina - Shenyang
1 program
1
ASP2151Phase 21 trial
Active Trials
NCT00487682Completed403Est. Sep 2008
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
Varicella Zoster VaccinePhase 2Vaccine
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
4 programs
1
ShingrixPhase 1/21 trial
Live attenuated herpes zoster vaccinePHASE_1Vaccine1 trial
ZOSTAVAXPHASE_22 trials
Varicella-zoster vaccinePHASE_3Vaccine
Active Trials
NCT01137669Completed34Est. Feb 2015
NCT01331161Completed77Est. Oct 2012
NCT01911065Completed54Est. Dec 2011
+1 more trials
Sinovac Biotech
Sinovac BiotechChina - Beijing
1 program
1
Low-dose experimental vaccinePhase 1/2Vaccine1 trial
Active Trials
NCT07400003Recruiting519Est. Apr 2027
Biocorp
BiocorpFrance - Issoire
1 program
1
Recombinant zoster vaccinePhase 1/2Vaccine1 trial
Active Trials
NCT06851832Active Not Recruiting960Est. Sep 2028
BravoVax
BravoVaxChina - Wuhan
1 program
1
Recombinant Zoster VaccinePhase 1Vaccine1 trial
Active Trials
NCT05718037Unknown40Est. Jul 2024
CanSino Biologics
CanSino BiologicsChina - Tianjin
1 program
1
Recombinant Zoster VaccinePhase 1Vaccine1 trial
Active Trials
NCT05991427Completed65Est. Nov 2024
GSK
GSKLONDON, United Kingdom
25 programs
Data collectionN/A1 trial
Data collectionN/A1 trial
Data collectionN/A1 trial
Data collectionN/A1 trial
Data collectionN/A1 trial
+20 more programs
Active Trials
NCT05811754Active Not Recruiting2,844Est. Mar 2028
NCT01772160Completed395Est. Oct 2016
NCT02487472Completed106Est. Aug 2017
+22 more trials
Merck & Co.
Merck & Co.RAHWAY, NJ
12 programs
Choosing to receive the vaccineN/AVaccine
Personalized letterN/A
ZOSTAVAX™N/A
Comparator: zoster vaccine livePHASE_3Vaccine
V212PHASE_3
+7 more programs
MAXVAX Biotechnology
MAXVAX BiotechnologyChina - Chengdu
5 programs
Low Dose Recombinant Herpes Zoster VaccinePHASE_1Vaccine1 trial
Low dose Recombinant Herpes Zoster VaccinePHASE_2Vaccine1 trial
Recombinant Zoster VaccinePHASE_3Vaccine1 trial
Recombinant Zoster VaccinePHASE_3Vaccine1 trial
Recombinant Zoster VaccinePHASE_3Vaccine1 trial
Active Trials
NCT05636436Active Not Recruiting132Est. Dec 2024
NCT05856084Active Not Recruiting924Est. Mar 2026
NCT07293065Active Not Recruiting12,000Est. Dec 2028
+2 more trials
Moderna
ModernaCAMBRIDGE, MA
1 program
mRNA-1468PHASE_1_2RNA Therapeutic1 trial
Active Trials
NCT05701800Active Not Recruiting659Est. Jun 2026
Lee's Pharmaceutical
Lee's PharmaceuticalChina - Guangzhou
1 program
Recombinant Human Interferon α-2b GelPHASE_31 trial
Active Trials
NCT05806918Unknown368Est. Aug 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Colorado TherapeuticsZostavax
MSDZoster Vaccine Live
Allergy TherapeuticsZOSTAVAX
MSDZOSTAVAX®
MSDZoster Vaccine, Live
MAXVAX BiotechnologyRecombinant Zoster Vaccine
MAXVAX BiotechnologyRecombinant Zoster Vaccine
MAXVAX BiotechnologyRecombinant Zoster Vaccine
Lee's PharmaceuticalRecombinant Human Interferon α-2b Gel
GSKHZ/su vaccine
GSKHZ/su
GSKHZ/su vaccine
GSKHZ/su vaccine GSK1437173A
GSKGSK Biologicals Herpes Zoster subunit
GSKHerpes Zoster Vaccine GSK1437173A

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 124,499 patients across 50 trials

Persistence of Protection by Shingrix

Start: Jul 2020Est. completion: Jun 2024105 patients
Phase 4Completed
NCT01556451MSDZoster Vaccine Live

ZOSTAVAX™ Safety and Immunogenicity in Korean Adults (V211-034)

Start: Apr 2012Est. completion: Oct 2012180 patients
Phase 4Completed

T Cell Responses to Varicella Zoster Virus (VZV) Vaccine SLVP020

Start: Sep 2010Est. completion: Dec 201154 patients
Phase 4Completed
NCT00681031MSDZOSTAVAX®

Zostavax® at Minimum Release Specification Approaching Expiry (V211-044)

Start: May 2008Est. completion: Jun 200896 patients
Phase 4Completed
NCT00550745MSDZoster Vaccine, Live

ZOSTAVAX™ Safety Study in Subjects ≥ 60 Years of Age (V211-020)

Start: Sep 2007Est. completion: Jan 200911,999 patients
Phase 4Completed
NCT07293065MAXVAX BiotechnologyRecombinant Zoster Vaccine

A Phase III Clinical Trial to Evaluate Long-Term Protective Efficacy of Recombinant Zoster Vaccine (CHO Cell)

Start: Dec 2025Est. completion: Dec 202812,000 patients
Phase 3Active Not Recruiting
NCT06654700MAXVAX BiotechnologyRecombinant Zoster Vaccine

Phase III Clinical Trial of Lot-to-lot Consistency of Recombinant Herpes Zoster Vaccine (CHO Cell).

Start: Dec 2024Est. completion: May 20251,200 patients
Phase 3Not Yet Recruiting
NCT06447779MAXVAX BiotechnologyRecombinant Zoster Vaccine

Efficacy, Safety and Immunogenicity Study of Recombinant Zoster Vaccine(CHO Cell) in Adults Aged 40 Years and Older

Start: Jul 2024Est. completion: Sep 202725,000 patients
Phase 3Active Not Recruiting
NCT05806918Lee's PharmaceuticalRecombinant Human Interferon α-2b Gel

Non-inferiority Study of ZK-A03 in Treatment of Herpes Zoster Before and After the Alteration of the Active Ingredient Manufacturer

Start: Apr 2023Est. completion: Aug 2023368 patients
Phase 3Unknown
NCT05371080GSKHZ/su vaccine

A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults

Start: Aug 2022Est. completion: Aug 20273,038 patients
Phase 3Active Not Recruiting

A Study on the Immune Response and Safety of the Shingles Vaccine and the Influenza Vaccine When Either is Given to Healthy Adults at the Same Time or Following a COVID-19 Booster Vaccine

Start: Oct 2021Est. completion: Aug 20222,013 patients
Phase 3Completed
NCT04176939GSKHZ/su vaccine

A Study to Test GlaxoSmithKline's (GSK) Herpes Zoster (HZ) Subunit Vaccine's Long-term Immune Response in Previously Vaccinated Kidney Transplant Adults and Then to Test if 2 Additional Doses of the Vaccine Are Safe and Able to Generate an Immune Response

Start: Dec 2019Est. completion: Jun 202468 patients
Phase 3Completed
NCT03439657GSKHZ/su vaccine GSK1437173A

Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With Prevenar13 in Adults Aged 50 Years and Older

Start: Apr 2018Est. completion: Mar 2020913 patients
Phase 3Completed
NCT02979639GSKGSK Biologicals Herpes Zoster subunit

Study to Evaluate the Impact of Reactogenicity on Quality of Life (QoL), After Administration of GlaxoSmithKline (GSK) Biologicals' Candidate Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) in Adults ≥ 50 Years of Age

Start: Jan 2017Est. completion: May 2018404 patients
Phase 3Completed
NCT02723773GSKHerpes Zoster Vaccine GSK1437173A

A Long-term Follow-up Study (ZOE-LTFU) of Two Studies 110390 (ZOSTER-006) and 113077 (ZOSTER-022) to Assess the Efficacy, Safety, and Immunogenicity Persistence of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine and Assessment of 1 or 2 Additional Doses in Two Subgroups of Older Adults

Start: Apr 2016Est. completion: Jan 20247,539 patients
Phase 3Completed
NCT02735915GSKHerpes Zoster Vaccine GSK1437173A

Study to Evaluate Immunogenicity and Safety of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine at 9 and 10 Years After Vaccine Administration and Assessment of Re-vaccination With 2 Additional Doses at 10 Years After Initial Vaccination, in Healthy Subjects Aged 60 Years of Age(YOA) and Older

Start: Apr 2016Est. completion: Oct 201870 patients
Phase 3Completed
NCT02581410GSKGSK Biologicals Herpes Zoster subunit

Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) in Adults ≥ 65 Years of Age With and Without Zostavax® Vaccination at Least 5 Years Earlier

Start: Dec 2015Est. completion: Aug 2017430 patients
Phase 3Completed
NCT02519855MSDZOSTAVAX™

Study to Evaluate Immunogenicity, Safety, and Tolerability of ZOSTAVAX™ Vaccine (Zoster Vaccine Live, V211) Administered Concomitantly Versus Nonconcomitantly With Quadrivalent Influenza Virus Vaccine (Inactivated) in Participants ≥50 Years of Age (V211-062)

Start: Sep 2015Est. completion: Jan 2016882 patients
Phase 3Completed
NCT02075515GSKHerpes Zoster vaccine

Consistency, Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults ≥ 50 Years of Age

Start: Aug 2014Est. completion: Apr 2016651 patients
Phase 3Completed
NCT02180295MSDV212 Lot 1

A Lot-to-Lot Consistency Study to Evaluate Safety, Tolerability, and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Healthy Adults (V212-014)

Start: Jul 2014Est. completion: Mar 20150
Phase 3Withdrawn
NCT02045836GSKHerpes Zoster vaccine GSK 1437173A

Study to Evaluate Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A When Co-administered With Pneumovax 23™ in Adults Aged 50 Years and Older

Start: Mar 2014Est. completion: Jun 2016865 patients
Phase 3Completed
NCT02052596GSKHerpes Zoster vaccine GSK 1437173A

Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) When Co-administered With GSK Biologicals' Diphtheria, Tetanus and Pertussis Vaccine (Boostrix®) in Adults Aged 50 Years and Older

Start: Feb 2014Est. completion: Apr 2016935 patients
Phase 3Completed
NCT01954251GSKHerpes Zoster vaccine GSK 1437173A

Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With GSK Biologicals' Seasonal Influenza Vaccine GSK2321138A in Adults Aged 50 Years and Older

Start: Oct 2013Est. completion: Mar 2015829 patients
Phase 3Completed

Phase III Study of ASP2151 in Herpes Zoster Patients

Start: Aug 2013Est. completion: Jul 2015751 patients
Phase 3Completed
NCT01777321GSKHerpes zoster vaccine GSK1437173A

Safety and Immunogenicity Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine GSK1437173A When Administered Subcutaneously Intramuscularly in Adults Aged ≥50 Years

Start: Jun 2013Est. completion: Nov 201460 patients
Phase 3Completed
NCT01827839GSKHerpes Zoster vaccine

Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine GSK1437173A in Adults With a Prior Episode of Herpes Zoster

Start: Jun 2013Est. completion: Nov 201496 patients
Phase 3Completed
NCT01751165GSKHerpes zoster vaccine GSK1437173A

Safety and Immunogenicity of Different Dosing Schedules of GlaxoSmithkline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine in Adults 50 Years of Age or Older

Start: Mar 2013Est. completion: Apr 2015354 patients
Phase 3Completed
NCT01527370MSDZoster Vaccine Live

Safety, Tolerability, and Immunogenicity of Zoster Vaccine Live (ZOSTAVAX™) in Healthy Adults in India (V211-025)

Start: Oct 2012Est. completion: Apr 2013250 patients
Phase 3Completed
NCT01327144EMSFamciclovir

Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster

Start: Jun 2012Est. completion: Jul 2017177 patients
Phase 3Completed
NCT01505647MSDZoster Vaccine, Live

Safety and Immunogenicity of Zoster Vaccine (ZOSTAVAX™) Made With an Alternative Manufacturing Process (AMP) (V211-042 AM1)

Start: Apr 2012Est. completion: Nov 2012498 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011)

Start: Jun 2011Est. completion: Apr 20175,305 patients
Phase 3Completed

Immunogenicity and Safety Study of ZOSTAVAX Administered by Intramuscular or Subcutaneous Route to Participants Aged From 50 Years Old (V211-045)

Start: Jun 2011Est. completion: Oct 2012354 patients
Phase 3Completed

Safety, Tolerability, and Immunogenicity of a Booster Dose of Zoster Vaccine, Live (V211-029)

Start: Apr 2011Est. completion: May 2015600 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (V212-001)

Start: Nov 2010Est. completion: Dec 20151,257 patients
Phase 3Completed
NCT00535730MSDZoster Vaccine, Live,

ZOSTAVAX™ Administered Concomitantly With PNEUMOVAX™ 23 (V211-012)(COMPLETED)

Start: Jun 2007Est. completion: Feb 2008473 patients
Phase 3Completed
NCT00322231MSDzoster vaccine live

A Study of an Investigational Zoster Vaccine, in Subjects With a History of Herpes Zoster (V211-014)

Start: May 2006Est. completion: Jul 2007101 patients
Phase 3Completed
NCT00231816MSDZOSTAVAX™

A Study of an Investigational Zoster Vaccine in Subjects With a History of Varicella (Chickenpox) Given Concomitantly With Another Vaccine (V211-011)

Start: Sep 2005Est. completion: Mar 2006763 patients
Phase 3Completed
NCT00130793MSDComparator: zoster vaccine live

A Study to Evaluate Safety, Tolerability, and Immunogenicity of an Investigational Zoster Vaccine In Subjects With a History of Varicella (Chickenpox)(V211-010)(COMPLETED)

Start: Aug 2005Est. completion: Nov 2005368 patients
Phase 3Completed
NCT00007501MSDVaricella-zoster vaccine

Shingles Prevention Study

Start: Nov 1998Est. completion: Feb 201138,456 patients
Phase 3Completed
NCT05856084MAXVAX BiotechnologyLow dose Recombinant Herpes Zoster Vaccine

Immunogenicity and Safety of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 30 Years and Above

Start: May 2023Est. completion: Mar 2026924 patients
Phase 2Active Not Recruiting

A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Adults With Autoimmune Disease (V212-009)

Start: Feb 2012Est. completion: Feb 2013354 patients
Phase 2Completed

Live Zoster Vaccine in HIV-Infected Adults on Antiretroviral Therapy

Start: Apr 2009Est. completion: Jan 2012395 patients
Phase 2Completed

Dose-finding Study of ASP2151 in Subjects With Herpes Zoster

Start: Nov 2007Est. completion: Sep 2008403 patients
Phase 2Completed
NCT00546819MSDZoster Vaccine, Live

ZOSTAVAX™ in Patients on Chronic/Maintenance Corticosteroids (V211-017) (COMPLETED)

Start: Oct 2007Est. completion: Aug 2010309 patients
Phase 2Completed
NCT07400003Sinovac BiotechLow-dose experimental vaccine

Study to Evaluate the Safety and Immunogenicity of a Lyophilized Herpes Zoster Virus mRNA Vaccine

Start: Jan 2026Est. completion: Apr 2027519 patients
Phase 1/2Recruiting
NCT06851832BiocorpRecombinant zoster vaccine

Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell) in Healthy Chinese Population Aged 40 Years and Older

Start: Feb 2025Est. completion: Sep 2028960 patients
Phase 1/2Active Not Recruiting

Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Count Less Than 300 or Greater Than or Equal to 300 and a Healthy Control Population

Start: Mar 2023Est. completion: Oct 2027225 patients
Phase 1/2Recruiting

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age

Start: Jan 2023Est. completion: Jun 2026659 patients
Phase 1/2Active Not Recruiting

A Study to Test GlaxoSmithKline's (GSK) Candidate Vaccine-GSK1437173A for Prevention of Shingles in Children With Kidney Transplant

Start: Oct 2019Est. completion: Mar 2027184 patients
Phase 1/2Recruiting
NCT05991427CanSino BiologicsRecombinant Zoster Vaccine

A Study to Evaluate the Safety and Immunogenicity of ChAdOx1-VZV in Healthy Adults Aged 50-65 Years

Start: Nov 2023Est. completion: Nov 202465 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

53 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 124,499 patients
Vaccine is the dominant modality (98% of programs)
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.