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Hereditary Angioedema Types I and II

4
Pipeline Programs
3
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

CSL Seqirus
CSL SeqirusUK - Maidenhead
4 programs
1
1
2
C1-esterase inhibitorPhase 3
Low-volume C1-esterase inhibitorPhase 3
C1-esterase inhibitor - single intravenous dosePhase 1/2
BerinertPhase 1
CSL Behring
CSL BehringIL - Bradley
4 programs
BerinertPHASE_11 trial
C1-esterase inhibitor - single intravenous dosePHASE_1_2
C1-esterase inhibitorPHASE_31 trial
Low-volume C1-esterase inhibitorPHASE_31 trial
Active Trials
NCT01760343Completed16Est. Mar 2013
NCT02316353Completed126Est. Sep 2017
NCT01912456Completed90Est. Oct 2015
Parexel
ParexelMA - Boston
1 program
C1-esterase inhibitor - single intravenous dosePHASE_1_21 trial
Active Trials
NCT01576523Completed18Est. Dec 2012

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
CSL BehringC1-esterase inhibitor
CSL BehringLow-volume C1-esterase inhibitor
ParexelC1-esterase inhibitor - single intravenous dose
CSL BehringBerinert

Clinical Trials (4)

Total enrollment: 250 patients across 4 trials

NCT02316353CSL BehringC1-esterase inhibitor

A Study to Evaluate the Long-term Clinical Safety and Efficacy of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Start: Dec 2014Est. completion: Sep 2017126 patients
Phase 3Completed
NCT01912456CSL BehringLow-volume C1-esterase inhibitor

A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Start: Jan 2014Est. completion: Oct 201590 patients
Phase 3Completed
NCT01576523ParexelC1-esterase inhibitor - single intravenous dose

A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route

Start: Apr 2012Est. completion: Dec 201218 patients
Phase 1/2Completed

A Study to Evaluate the Safety and Pharmacokinetics of Two Formulations of C1-esterase Inhibitor

Start: Jan 2013Est. completion: Mar 201316 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.