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Healthy Adult Subjects

21
Pipeline Programs
15
Companies
32
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
21
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 30 programs with unclassified modality

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
9 programs
9
ONO-2952Phase 11 trial
ONO-2952Phase 11 trial
ONO-4053Phase 11 trial
ONO-4053Phase 11 trial
ONO-6950Phase 11 trial
+4 more programs
Active Trials
NCT01364441Completed48
NCT01613703Completed16
NCT01379586Terminated15
+6 more trials
Biocorp
BiocorpFrance - Issoire
2 programs
2
FG-4592Phase 11 trial
RoxadustatPhase 1Small Molecule
Active Trials
NCT01376063Completed20Est. Jun 2010
Yunovia
YunoviaKorea - Hwaseong
2 programs
2
ID110521156Phase 1
ID110521156Phase 1
Ildong Pharmaceutical
2 programs
2
ID110521156Phase 11 trial
ID110521156Phase 11 trial
Active Trials
NCT06063291Completed36Est. Jul 2024
NCT06635226Recruiting36Est. Jun 2025
Prevail Therapeutics
2 programs
2
PegilodecakinPhase 1
PegilodecakinPhase 1
Kashiv BioSciences
Kashiv BioSciencesNJ - Piscataway
1 program
1
ADL-018 AutoinjectorPhase 11 trial
Active Trials
NCT06929052Completed150Est. Aug 2025
Alvotech
AlvotechLUXEMBOURG, Luxembourg
1 program
1
AVT05Phase 11 trial
Active Trials
NCT05632211Completed336Est. Oct 2023
Microbiotix
MicrobiotixMA - Worcester
1 program
1
MBX-400Phase 11 trial
Active Trials
NCT01433835Completed48Est. Sep 2012
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
methylnaltrexonePhase 11 trial
Active Trials
NCT01366378Completed18Est. Feb 2007
Connect Biopharma
Connect BiopharmaSAN DIEGO, CA
3 programs
CBP-174PHASE_11 trial
CBP-307PHASE_11 trial
Test drugPHASE_11 trial
Active Trials
NCT04811469Completed74Est. May 2022
NCT05040113Completed6Est. Oct 2021
NCT05917782Completed324Est. Oct 2023
Biogen
BiogenCAMBRIDGE, MA
2 programs
BIIB118PHASE_11 trial
OmaveloxolonePHASE_15 trials
Active Trials
NCT02691702Completed97Est. Jan 2017
NCT07019064Completed52Est. Aug 2025
NCT06054893Recruiting35Est. Nov 2030
+3 more trials
Fulcrum Therapeutics
2 programs
FTX-6058/placebo oral capsulePHASE_11 trial
Losmapimod 15 mg oral tabletPHASE_11 trial
Active Trials
NCT04586985Completed109Est. Nov 2022
NCT05002231Completed18Est. Oct 2021
Thea Pharma
Thea PharmaMA - Waltham
1 program
T2309N/A1 trial
Active Trials
NCT04596605CompletedEst. Mar 2021
IQVIA
IQVIADURHAM, NC
1 program
AVT05PHASE_1
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
PegilodecakinPHASE_13 trials
Active Trials
NCT04194892Completed12Est. Mar 2018
NCT03381547Completed12Est. Feb 2018
NCT03267732Completed24Est. Oct 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
BiogenOmaveloxolone
Kashiv BioSciencesADL-018 Autoinjector
Ildong PharmaceuticalID110521156
BiogenOmaveloxolone
Ildong PharmaceuticalID110521156
Connect BiopharmaTest drug
BiogenOmaveloxolone
BiogenOmaveloxolone
AlvotechAVT05
Connect BiopharmaCBP-307
Fulcrum TherapeuticsLosmapimod 15 mg oral tablet
Connect BiopharmaCBP-174
Fulcrum TherapeuticsFTX-6058/placebo oral capsule
BiogenOmaveloxolone
BiogenOmaveloxolone

Showing 15 of 32 trials with date data

Clinical Trials (32)

Total enrollment: 1,957 patients across 32 trials

NCT07019064BiogenOmaveloxolone

A Study to Learn How BIIB141 (Omaveloxolone) is Processed in the Body When Taken as Capsules Compared to Sprinkled on Yogurt in Healthy Adults Aged 18 to 55

Start: Jun 2025Est. completion: Aug 202552 patients
Phase 1Completed
NCT06929052Kashiv BioSciencesADL-018 Autoinjector

A Comparative Pharmacokinetic Study of ADL-018 Autoinjector Compared to A Pre-filled Syringe in Healthy Subjects.

Start: Jan 2025Est. completion: Aug 2025150 patients
Phase 1Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ID110521156 in Healthy Adult Subjects

Start: Nov 2024Est. completion: Jun 202536 patients
Phase 1Recruiting
NCT06054893BiogenOmaveloxolone

A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old

Start: Jul 2024Est. completion: Nov 203035 patients
Phase 1Recruiting

Single Ascending Oral Dose Phase 1 Study of ID110521156 in Healthy Adult Subjects

Start: Nov 2023Est. completion: Jul 202436 patients
Phase 1Completed

A Study to Evaluate the Pharmacokinetics Similarity of CBP-201 in Healthy Adult Chinese Subjects

Start: Jul 2023Est. completion: Oct 2023324 patients
Phase 1Completed
NCT05927649BiogenOmaveloxolone

A TQTc Study for Omaveloxolone

Start: Jul 2023Est. completion: Sep 202330 patients
Phase 1Completed
NCT05909644BiogenOmaveloxolone

An Open-label DDI Study of Omaveloxolone in Healthy Subjects

Start: Jul 2023Est. completion: Aug 202320 patients
Phase 1Completed

A Study to Investigate the PK, Safety, and Tolerability Between AVT05, US and EU Simponi® in Healthy Adult Participants

Start: Dec 2022Est. completion: Oct 2023336 patients
Phase 1Completed

A Study On Human Mass Balance And Biotransformation

Start: Sep 2021Est. completion: Oct 20216 patients
Phase 1Completed
NCT05002231Fulcrum TherapeuticsLosmapimod 15 mg oral tablet

Relative Bioavailability and Food Effect Study of Losmapimod 15 mg Tablets

Start: Aug 2021Est. completion: Oct 202118 patients
Phase 1Completed

Safety, Tolerability and Pharmacokinetics of CBP-174 in Healthy Adults

Start: May 2021Est. completion: May 202274 patients
Phase 1Completed
NCT04586985Fulcrum TherapeuticsFTX-6058/placebo oral capsule

Safety, Tolerability and Pharmacokinetics of FTX-6058

Start: Oct 2020Est. completion: Nov 2022109 patients
Phase 1Completed
NCT04008186BiogenOmaveloxolone

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Start: Jun 2019Est. completion: Aug 201961 patients
Phase 1Completed
NCT03664453BiogenOmaveloxolone

A Pharmacokinetic Study of Omaveloxolone in Healthy Volunteers

Start: Oct 2018Est. completion: Nov 201832 patients
Phase 1Completed

A Crossover Study to Evaluate Pegilodecakin (LY3500518) in Healthy Participants

Start: Jan 2018Est. completion: Mar 201812 patients
Phase 1Completed

A 3-Way Crossover Study to Evaluate the Pharmacokinetics in Participants After Dosing With Pegilodecakin (LY3500518)

Start: Dec 2017Est. completion: Feb 201812 patients
Phase 1Completed

A Study to Evaluate the Pharmacokinetics in Participants After Dosing With Pegilodecakin (LY3500518)

Start: Sep 2017Est. completion: Oct 201724 patients
Phase 1Completed

Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers

Start: Mar 2016Est. completion: Jan 201797 patients
Phase 1Completed

ONO-2952 Single-dose PET Study in Healthy Adult Subjects

Start: Aug 201216 patients
Phase 1Completed

Single Dose Escalation Study of ONO-9054 in Healthy Volunteers

Start: Jan 201248 patients
Phase 1Completed

A Phase I Study to Evaluate Safety, Tolerability and Pharmacokinetics of ONO-4053 in Healthy Volunteers

Start: Jan 2012Est. completion: Aug 201280 patients
Phase 1Completed

Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers

Start: Sep 2011Est. completion: Sep 201248 patients
Phase 1Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONO-6950 in Healthy Adult Subjects

Start: Jul 201124 patients
Phase 1Completed

A Phase I Study to Evaluate Safety, Tolerability and Pharmacokinetics of ONO-4053 in Healthy Volunteers

Start: Jun 201115 patients
Phase 1Terminated

Single-Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ONO-2952 in Healthy Adult Subjects

Start: May 201148 patients
Phase 1Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONO-6950 in Healthy Adult Subjects

Start: Jan 201156 patients
Phase 1Completed

ONO-7746 Study in Healthy Adult Subject

Start: Apr 201072 patients
Phase 1Completed

Study to Investigate the Interaction Between FG-4592 and Rosiglitazone in Healthy Adult Subjects

Start: Mar 2010Est. completion: Jun 201020 patients
Phase 1Completed

ONO-7746 Study in Healthy Adult Subjects

Start: Aug 200948 patients
Phase 1Completed
NCT01366378Bausch Healthmethylnaltrexone

Effect of Cimetidine on the Single-Dose PK of IV- Administered MNTX

Start: Jan 2007Est. completion: Feb 200718 patients
Phase 1Completed

Gastrointestinal Tolerance Assessment of T2309

Start: Jul 2020Est. completion: Mar 2021
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 1,957 patients
15 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.